Term
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Definition
| Competitive inhibition of transpeptidase enzyme (penicillin binding proteins) à inhibits cell wall synthesis |
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Term
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Definition
| Competitive inhibition of transpeptidase enzyme (penicillin binding proteins) inhibits cell wall synthesis |
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Term
| Penicillinase-R penicillins (MOA) |
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Definition
| Competitive inhibition of transpeptidase enzyme (penicillin binding proteins) inhibits cell wall synthesis |
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Term
| Carboxy/Ureidopenicillins (MOA) |
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Definition
| Competitive inhibition of transpeptidase enzyme (penicillin binding proteins) inhibits cell wall synthesis |
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Term
| β-Lactamase inhibitors (MOA) |
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Definition
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Term
| Cephalosporins - 1st generation (MOA) |
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Definition
Same as penicillins (β-lactam drugs inhibit cell wall synthesis)
Less susceptible to penicillinases |
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Term
| Cephalosporins - 2nd generation (MOA) |
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Definition
Same as penicillins (β-lactam drugs inhibit cell wall synthesis)
Less susceptible to penicillinases |
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Term
| Cephalosporins - 3rd generation (MOA) |
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Definition
Same as penicillins (β-lactam drugs inhibit cell wall synthesis)
Less susceptible to penicillinases |
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Term
| Cephalosporins - 4th generation (MOA) |
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Definition
Same as penicillins (β-lactam drugs inhibit cell wall synthesis)
Less susceptible to penicillinases |
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Term
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Definition
| Binds to PBP in GM- only (No GM+ or anaerobe) |
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Term
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Definition
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Term
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Definition
TMP inhibits DHF reductase (DHF THF)
SMX is PABA analogue that inhibits dihydropteroate synthase
Overall, they decrease folate and DNA, RNA, and proteins |
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Term
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Definition
Inhibit bacterial DNA gyrase (topo II) Gm-
or Topo 4 (Gm+)
Inhibits DNA synthesis
BacteriCIDAL |
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Term
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Definition
Metabolized INSIDE anaerobic bacteria and damages DNA
BacteriCIDAL |
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Term
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Definition
| Cationic basic proteins (detergent) that disrupts osmotic properties of the membrane. Polymixins “mix up” membranes |
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Term
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Definition
bactericidal
Synergistic with β-lactam antibiotics b (must diffuse though cell wall) Inhibits 30S |
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Term
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Definition
bacteriostatic
Inhibit 30S
R. Efflux pumps+ ribosome protection proteins |
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Term
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Definition
Inhibit protein synthesis by binding to the 50S subunit (or 23 srRNA)
Bacteriostatic |
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Term
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Definition
Inhibit protein synthesis by binding to the 50S subunit (or 23 srRNA)
Bacteriostatic |
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Term
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Definition
Inhibit protein synthesis by binding to the 50S subunit (or 23 srRNA)
Bacteriostatic |
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Term
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Definition
Inhibits cell wall mucopeptide formation by binding D-ala D-ala portion of cell wall precursors
Bactericidal except for enterococcus |
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Term
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Definition
| Inhibits proteins synthesis, both bind to different sites on the 50S subunit |
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Term
| Cyclic lipopeptides (MOA) |
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Definition
| Calcium dependent binding on plasma membrane with depolarization (K+) release and death |
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Term
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Definition
| Inhibit protein synthesis (binds to the 30S subunit) |
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Term
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Definition
| Inhibits protein synthesis (binds to the 50S subunit) near the 30S subunit, prevents 70S formation (unique) |
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