Term
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Definition
cycloserine
D-ala analog
inhibit stage 1 and 2
inhib syn of d-ala-d-ala |
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Term
|
Definition
neosporin
inhibits key dephosphorylation step in stage 2
cant transport NAM out
NO IV, nephrontoxicity |
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Term
|
Definition
6 amino para penicillanic acid
amidase product |
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Term
|
Definition
procaine/benzathine
adjunct
organic salt with penicllin G |
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Term
|
Definition
beta lactamase inhibitor
irreversible inhib
suicide |
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Term
|
Definition
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Term
|
Definition
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Term
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Definition
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Term
|
Definition
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Term
|
Definition
cephalosporin, carbacephem
resistant to b-lactamase and oral |
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Term
|
Definition
cephalosporin
methyl-tetrazole-thiomethyl (MTT)
intolerance to alcohol
serious bleeding
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Term
|
Definition
monobactam
synthetic
react with transpeptidase
beta lactamase resistance via methyl |
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Term
|
Definition
carbapenem
IV
inhib of transpeptidase |
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Term
|
Definition
carbapenem
not degraded by dehydropeptidase in kidney
IV
inhib of transpeptidase |
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Term
|
Definition
carbapenem
not degraded by dehydropeptidase in kidney
IV
inhib of transpeptidase |
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Term
|
Definition
blocks dehydropeptidase I
adjunct with cephalosporins
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Term
|
Definition
carbapenem
UTI, intrabdoimnal
inhibits PBP
stable against beta lactamase and dehydropeptidase I
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Term
|
Definition
aminoglycoside
reserved for patients resistant to other aminoglycosides |
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Term
|
Definition
aminoglycoside
hydrolysis in solution
binds to 30s
gram negative
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Term
|
Definition
aminoglycoside
bind to 30S
cause misreading
bacteriocidial |
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Term
|
Definition
tetracycline
bind to 30S, requires Mg2+
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Term
|
Definition
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Term
|
Definition
ketolide
(look for 3 ketos)
MDR gram +
bind to 23S on 50S
binds tighter |
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Term
|
Definition
sulfonamides
bacteriostatic
comp antag of PABA
cant syn folic acid
systemic and UTI |
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Term
|
Definition
sulfisoxazole acetyl prodrug
no bitter taste |
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Term
|
Definition
sulfisoxazole
no antibacterial activity
analgesic for UTI
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Term
|
Definition
inhib dihydrofolate reductase
20,000 more selective for bacteria
use with patients sensitive to sulfonamides
decrease metab of warfarin |
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Term
|
Definition
| only sulfonamide used parenterally or ophthalmically |
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Term
|
Definition
used in burn patients
silver is active |
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Term
|
Definition
used in burn patients
inhibit carbonic anhydrase
active metabolite: NH2 to COOH |
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Term
|
Definition
active ingredient is cleaved then PABA analog
ulcerative colitis |
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Term
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Definition
sulfones
antag by PABA
bacteriostatic
leprosy |
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Term
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Definition
sulfones
antag by PABA
bacteriostatic
leprosy |
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Term
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Definition
UTI
forms formaldehyde in acidic environment
reacts with amino group in protein to form Schifft base
complexed with acid to lower urine pH
enteric coated |
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