Term
|
Definition
| 30S ribosome binding=messes up protein synthesis |
|
|
Term
|
Definition
| 50S ribosome binding=messes up protein synthesis |
|
|
Term
|
Definition
| 50S binding=messes up protein synthesis |
|
|
Term
|
Definition
| Disrupts DNA Topoisomerase |
|
|
Term
|
Definition
Tobramycin
Amikacin
Neomycin
Gentamicin
Streptomycin
"TANGS" |
|
|
Term
|
Definition
Clarithro/Azithromycin
Erythromycin
Tilmicosin
Tylosin
Tulathromycin |
|
|
Term
|
Definition
Chloramphenicol
Florfenicol |
|
|
Term
|
Definition
Ciprofloxacin
Difloxacin
Enrofloxacin
Marbofloxacin
Orbifloxacin |
|
|
Term
| Drugs Affecting DNA/RNA Synthesis |
|
Definition
| Fluoroquinolones, Rifampicin, Diaminopyrimidines, Potentiated sulfas, Griseofulvin, Metronidazole, Flucytosine, |
|
|
Term
| Drugs Affecting Protein Synthesis |
|
Definition
Macrolides
Lincosamides
Tetracyclines
Chloramphenicol
Florfenicol
Aminoglycosides |
|
|
Term
| Drugs Affecting Cell Wall Integrity |
|
Definition
Penicillins
Cephalosporins
Vancomycin |
|
|
Term
| Mechanism of Resistance for: Sulfonamides&Diaminopyrimidines |
|
Definition
Decreased Permeability
Production of drug-insensitive enzymes
Overexpression of sensitive enzymes |
|
|
Term
| Mechanism of Resistance for: Fluoroquinolones |
|
Definition
Target site (DNA gyraseTopoisomerase) mutation
Decreased Permeability
Efflux
Target site protection |
|
|
Term
| Mechanism of Resistance for: Macrolides |
|
Definition
Target site (ribosome) mutation
Decreased permeability
Inactivating enzymes
Efflux |
|
|
Term
| Mechanism of Resistance for: Lincosamides |
|
Definition
Decreased ribosomal binding
Inactivating enzymes |
|
|
Term
| Mechanism of Resistance for: Tetracyclines |
|
Definition
Efflux
Ribosomal protection
Drug detox
Target site (ribosome) mutation |
|
|
Term
| Mechanism of Resistance for: Chloramphenicol/Florfenicol |
|
Definition
Targe Site (ribosome) mutation
Decreased Permeability
Inactivating Enzymes
Efflux |
|
|
Term
| Mechanism of Resistance for: Aminoglycosides |
|
Definition
Modifying enzymes
decreased permeability
Target site (ribosome) mutation
Efflux |
|
|
Term
| Mechanism of Resistance for: Penicillins |
|
Definition
Reduced permeability
Altered penicillin-binding protein
**B-lactamase
Ribosomal mutations,
Efflux |
|
|
Term
| Mechanism of Resistance for: Cephalosporins |
|
Definition
Inactivating enzymes (B-lactamases)
Reduced permeability
Altered penicillin binding protein
Efflux |
|
|
Term
| Mechanism of Resistance for: Vancomycin |
|
Definition
| Target resistance (cell wall) |
|
|
Term
|
Definition
| 1st generation parenteral |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| 3rd generation parenteral |
|
|
Term
|
Definition
|
|
Term
|
Definition
| 3rd generation parenteral |
|
|
Term
|
Definition
|
|
Term
| Group 1 Cephalosporin Drugs |
|
Definition
Cephalothin
cefazolin
Cephapirin
"Mr. Fazoli is thin bc of 1 aspirin" |
|
|
Term
| Group 2 Cephalosporin drugs |
|
Definition
Cefadroxil
Cephalexin
"Dr. Oxil drives 2 Lexuses" |
|
|
Term
| Group 3 Cephalosporin Drugs |
|
Definition
Cefotetan
Cefoxitin
Cefuroxime
"3 tet fox is furious" |
|
|
Term
| Group 4 Cephalosporin Drugs |
|
Definition
Cefotaxime
Ceftizoxime
Ceftriaxone
Ceftiofur
Cefovecin |
|
|
Term
| Group 5 Cephalosporin Drugs |
|
Definition
Cefixime
Cefpodoxime
"Five Fix a Pod" |
|
|
Term
| Group 6 Cephalosporin Drugs |
|
Definition
|
|
Term
| Group 7 Cephalosporin Drugs |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Chlortetracycline
Doxycycline
Minocycline
Oxytetracycline |
|
|
Term
|
Definition
|
|
Term
|
Definition
Penicillin G
Penicillin V |
|
|
Term
|
Definition
Amoxicillin
Ampicillin
Hetacillin |
|
|
Term
| Penicillinase Resistant Penicillin Drugs |
|
Definition
Oxacillin
Methicillin
cloxacillin
dicloxacillin
Nafcillin |
|
|
Term
| Antipseudomonal penicillin drugs |
|
Definition
Carbenicillin
Piperacillin
Ticarcillin |
|
|
Term
| Beta lactamase resistant penicillin drugs |
|
Definition
|
|
Term
|
Definition
| Competes w/PABA and prevents if from being incorp into folate=cant make purine/pyrimidine/DNA |
|
|
Term
|
Definition
| 30S ribosome binding=messes up protein synthesis |
|
|
Term
|
Definition
| 50 S ribosome binding=messes up protein synthesis |
|
|
Term
|
Definition
| Disrupts cell membrane phospholipids |
|
|
Term
|
Definition
| Inhibits cell wall synthesis |
|
|
Term
|
Definition
| Causes loss of helical structure and strand breakage in DNA after entering the target cell |
|
|
Term
|
Definition
| inhibits cell wall synthesis and cell membrane permeability |
|
|
Term
|
Definition
| Stops bacterial RNA synthesis |
|
|
Term
|
Definition
| prevent Peptidoglycan bacterial cell wall synthesis and binds PBP in bacteral Cell membrane that controls shape/division |
|
|
Term
| Drugs ILLEGAL in food animals (EL) |
|
Definition
| Chloramphenicol, Clenbuterol, Diethylstilbesterol, Dimetridazole, Ipronidazole, Metronidazole, Furazolidone, Nitrofurazone, Sulfonamides in lactating dairy cattle, Enrofloxacin, Marbofloxacin, Difloxacin, Orbifloxacin, Vancomycin (Glycopeptide), Phenylbutazone in dairy cattle 20mo of age or older |
|
|
Term
|
Definition
Pasteurella*
Mannheima*
Actinobacillus*
Bordatella
Chlamydophila
Histophilus somni
Haemophilus
Nicotella |
|
|
Term
| Gram Positive Obligate Anaerobes |
|
Definition
Clostridium
Actinobaculum Suis |
|
|
Term
| Gram Negative Obligate Anaerobes |
|
Definition
Fusobacterium
Brachyspira
Bacteroides
Dichelobacter |
|
|
Term
|
Definition
| SCRAMBLED CANES Streptococcus, Corynebacterium, Rhodococcus,Rickettsia Actinomyces, Mycobacterium, Bacillus, Listeria, Erysipelothrix, Dermatophilus, Clostridium, Arcanobacterium, Nocardia, Enterococcus, Staphylococcus |
|
|
Term
|
Definition
|
|
Term
| Enterobacteraceae Species |
|
Definition
| Salmonella, E. coli, shigella, yersinia, citrobacter, enterobacter, klebsiella, proteus |
|
|
Term
|
Definition
Leptospira
Brachyspira
Borrelia
|
|
|
Term
|
Definition
Aminopenicillins
Tetracyclines
Macrolides
"Spirochetes go the the ATM" |
|
|
Term
|
Definition
Tetracyclines
(Lincosamides)
(Macrolides)
Fluoroquinolones
"Tough Little Motha F&%*" |
|
|
Term
| Gram Positive Spectrum ---- |
|
Definition
Metronidazole
Gr 6,7 cephalosporins
Polymyxins
Beta lactamase R
Aminoglycosides
Antipseudomonals
|
|
|
Term
| Gram+Obligate Anaerobe spectrum --- |
|
Definition
NOT WORKY=
Penicillinase Resistant
Florfenicol
Fluoroquinolones
Potentiated sulfonamides |
|
|
Term
| Respiratory Pathogen Spectrum ++ |
|
Definition
| Aminoglycosides, Penicillins, Aminopenicillins, Carbapenems, Amoxi-clav, Group 4,5 ceph, Macrolides, Chloramphenicol, Florfenicol, Fluoroquinolones, Potentiated Sulfas, Tetracyclines |
|
|
Term
| Enterobacteraceae Spectrum+++ |
|
Definition
| Aminoglycosides, Beta-lactamase resistant, Carbapenems, Amoxi-clav, ticarcillin-clav, Group 3,4,5 ceph, Chloramphenicol, Fluoroquinolones, Pot sulfas, Tetracyclines, Polymyxins |
|
|
Term
|
Definition
| Aminoglycosides, Antipseudomonal B lactam, Carbapenems, Group 4, 6, 7 ceph, Chloramphenicol, Fluoroquinolones |
|
|
Term
| Other Gram Neg Spectrum+++ |
|
Definition
| Aminopenicillins, Macrolides, Fluoroquinolones, Pot Sulfas |
|
|
Term
| Gram Neg Obligate Anaerobe spectrum ++ |
|
Definition
| Penicillins, Aminopenicllins, Carbapenems, Amoxi-clav, Group 3,4,5 ceph, Macrolides, Chloramphenicol, Tetracyclines, Metronidazole, Lincosamides |
|
|
Term
|
Definition
Nephrotoxic
Ototoxic
NM blockade |
|
|
Term
|
Definition
GI effects-dog,cat
Diarrhea-cattle
Diarrhea, hyperthermia, resp distress-foals
Severe diarrhea-horses
|
|
|
Term
|
Definition
Inh p450 enzymes
BM suppression
aplastic anemia in humans |
|
|
Term
|
Definition
Arthropathy-young, all species
Retinal degeneration in cats
Seizures-all species
DONT give to horses w/GI probs
Dont use in chks |
|
|
Term
|
Definition
Urine Crystals-all species
Dermatologic rxns-dogs
Metabolized by liver
Excreted via kidneys
idiosyncratic toxicosis-dogs
hypothyroid-dogs
blood dyscrasias-horses
|
|
|
Term
|
Definition
Hepatotoxic-Dog
Nephrotoxic w/high dose-cow,dog,horse
Photosensitivity/Anaphylaxis-all species
CV collapse w/rapid IV dosing-all species
Teeth discoloration-all species
|
|
|
Term
|
Definition
Enterocolitis-rabbits, horses
V/D-dog, cat, cow
Hypersensitivity-all species
|
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Hepatotoxicity in dogs
Diarrhea in foals-self limiting
CNS, inappetance, weakness in horses |
|
|
Term
|
Definition
DONT give to horses, rabbits or guinea pigs
dt disruption of flora and malabsorption |
|
|
Term
|
Definition
|
|
Term
| Aminoglycosides route of elimination |
|
Definition
| excreted unchanged in the urine |
|
|
Term
|
Definition
Metronidazole
Rifampicin(K9)
Sulfonamides(K9)
Tetracyclines
"MRS T hates liver" |
|
|
Term
|
Definition
Sulfonamides
Vancomycin
Aminoglycosides
Polymixin
Bacitracin
Tetracyclines
"Sick kidneys Vomit And Poop Big Toxins" |
|
|
Term
|
Definition
All Gram ++
Gram-Obligate anaerobes
Resp gram - |
|
|
Term
| Aminopenicillins Spectrum |
|
Definition
| Not susceptible= Enterobacteracieae, Pseudomonas |
|
|
Term
| Penicillinase Resistant B lactam Spectrum |
|
Definition
| Susceptible=G+aerobes ONLY |
|
|
Term
|
Definition
| NOT Susceptible=Other G-aerobes |
|
|
Term
|
Definition
NOT Susceptible=Pseudomonas, Other G-aerobes
Everyone else susceptible |
|
|
Term
| Group 1 cephalosporins Spectrum |
|
Definition
| Susceptible=Gram+ aerobes, G+obligate anaerobes |
|
|
Term
| Ticarcillin-Clav Spectrum |
|
Definition
| only Enterobacteraciae variably susceptible |
|
|
Term
| Group 2 cephalosporins Spectrum |
|
Definition
| Only Gram + aerobes and obligate anaerobes susceptible |
|
|
Term
| Group 3 Cephalosporins Spectrum |
|
Definition
Susceptible:
All Gram++
Enterobacteraciae
G-Obligate anaerobes |
|
|
Term
| Group 4 cephalosporins Spectrum |
|
Definition
|
|
Term
| Group 5 Cephalosporin Spectrum |
|
Definition
| NOT susceptible=Pseudomonas, Other G- |
|
|
Term
| Group 6 Cephalosporin Spectrum |
|
Definition
| Susceptible=ONLY Pseudomonas |
|
|
Term
| Group 7 Cephalosporins Spectrum |
|
Definition
| Susceptible= ONLY pseudomonas |
|
|
Term
|
Definition
| Susceptible=ONLY Gram+aerobes and obligate anaerobes |
|
|
Term
|
Definition
| Susceptible=Gram+aerobes and oblig anaerobes, Gram-oblig anaerobes |
|
|
Term
|
Definition
| NOT susceptible=Enterobacteraciea, Pseudomonas |
|
|
Term
|
Definition
| NOT susceptible=Other G- aerobes |
|
|
Term
|
Definition
| Susceptible=G+aerobes, G-Resp |
|
|
Term
| Fluoroquinolones Spectrum |
|
Definition
| NOT susceptible=Gram+ and Gram-obligate anaerobes |
|
|
Term
| Potentiated Sulfas Spectrum |
|
Definition
| NOT susceptible=Gram+ and Gram- obligate anaerobes, Psuedomonas |
|
|
Term
|
Definition
| NOT susceptible=Pseudomonas, Other G-aerobes, |
|
|
Term
|
Definition
Susceptible=Gram+ and Gram-Obligate anaerobes
Antiprotozoal |
|
|
Term
|
Definition
| Susceptible=ONLY enterobacteracieae |
|
|
Term
|
Definition
| Anything that is used to treat, diagnose, prevent, or control a disease. |
|
|
Term
|
Definition
Animal Medicinal Drug Use Clarification Act of 1994.
Vets can use approved animal and human drugs EL under certain conditions |
|
|
Term
|
Definition
Animal Drug Availability Act of 1996
Streamlined animal drug approval process. Authorized VFD category |
|
|
Term
| Beta lactam pharmacodynamics |
|
Definition
| T>MIC (close to 100% for gram-infections, 30-70% for gram+infections) |
|
|
Term
| Macrolides like Erythromycin pharmacodynamics |
|
Definition
|
|
Term
| Macrolides such as tilmicosin pharmocodynamics |
|
Definition
|
|
Term
| Macrolides like azithromycin pharmacodynamics |
|
Definition
| Debate over T>MIC vs. AUC:MIC |
|
|
Term
| Tetracyline pharmacodyamics |
|
Definition
|
|
Term
| Fluoroquinolones pharmacodynamics |
|
Definition
| AUC:MIC (target of 100-125) |
|
|
Term
| Aminoglycosides pharmacodynamics |
|
Definition
|
|
Term
| Sulfonamides pharmacodynamics |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
