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Antibiotics and Antivirals
adverse effects, indications, contraindications, drug-drug interactions, implement
20
Medical
Undergraduate 1
12/09/2008

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Term
Aminoglycosides
Definition
1.used when PCN is contraindicated
2.contraindicated w/ hearing loss
3.adverse:ototoxicity, nephrotoxicity
4.drug-drug:diuretics
Term
Gentamycin
Definition
An aminoglycoside that can cause nephrotoxicity
Term
Cephalosporins
Definition
1.contraindicted: allergy to PCN
2.adverse:bone marrow suppression,colitis
3.drug-drug: anticoagulants
alcohol-disulfiram reaction
Term
Keflex
Definition
A cephalosporin, avoid alcohol at least 72hrs post use
Term
While on this antibiotic, assist w/ ambulation, siderails,report severe diarrhea, avoid alcohol
Definition
Cephalosporin
Term
Fluoroquinolones
Definition
"cipro" tx bone and joint infections.
1.adverse:photosensitivity,HA,GI irritation
2.drug-drug:antacids,iron,carafate,theophyline
Term
Macrolides Etab Zpak
Definition
For patients w/ PCN allergy, frequently rx for URI
1.adverse:GI irritation
2.drug-drug:take on an empty stomach
digoxin,theophylline,corticosteroids,anticoagulants
3.implement:bathroom access
QD r/t long half life
Term
Lincosamides
Definition
"cleocin"increased toxic effects
watch for severe GI effects- diarrhea
adverse:colitis,bone marrow suppression,hypotension,cardiac arrest
Term
Penicillin
Definition
take on an empty stomach adverse:glossitis,stomatitis,bone marrow suppression,lethary
Term
Sulfonamides
Definition
inhibits synthesis of folic acid
1.contraindicated: allergy to thiazide diuretic, pregnancy
2.photosensitivity,hepatocellular necrosis,steven johnson's, hematuria, photophobia
3.durg-drug:antihyperglycemics, admin. no an empty stomach
4.monitor CBC and UA
Term
Tetracycline
Definition
1.adverse:GI,photosensitivity,teeth discoloration,bone marrow suppression
2.drug-drug:contraceptives,digoxin
3.take on an empty stomach, do not take with antacids or calcium
Term
Antibycobacterial
Definition
manage TB "isoniazid"
give w/meals
report numbness and tingling
adverse:hepatitis, bone marrow suppression
Term
Respiratory Antivirals
Definition
1.action:prevent shedding of the viral protein coat
2.adverse:insomnia,orthostatic hypotension
3.drug-drug:anticholinergics
4.implement:slow position changes,report difficulty talk and walk
Term
Anti Herpes & CMV
Definition
1.contraindicated in pregnancy
2.adverse: HA,hairloss
3.drug-drug:nephrotoxic meds,zidovudine
4.implement:wear gloves when applying topicals
Term
Anti HIV & AIDS
Definition
1.monitor CBC(bone marrow & Tcells)
2.adverse:hepatotoxicity,hyperglycemia, hyperlipidemia, lactic acidosis,
lipodystrophy, osteonecrosis,osteopenia
Term
Reverse Transcriptase Inhibitor
Definition
"niverapine" block RNA and DNA activities by binding to reverse transcriptase, which is needed to make more copies
Term
Protease inhibitor
Definition
block prtease activity
teratogenic, except saquinavir
contraindicated in pregnancy
Term
Nucleosides
Definition
"zidovudine" inhibit protein cell synthesis
adverse:HA,insomnia,head,GI,fever
Term
Fusion inhibitors
Definition
prevent fusion of the virus to the cell membrane
no contraindications
adverse:HA,myalgia,GI,head
drug-drug:contraceptives,rifampin, triazoloam,midazolam,pimozide
Term
Locally active antivirals
Definition
not absorbed systemically
iterfere w/ normal viral replications
adverse:burning,stinging,descomfort
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