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Antiarrythmic Drugs Review
Antiarrythmic Drugs Review
24
Pharmacology
Undergraduate 1
03/16/2010

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Cards

Term
What types of Cardiac Rhythm Disturbances may a patient suffer from (8)?
Definition
-Arrhythmias (changes from normal rate or heartbeat)
-Ectopic pacemaker
-Sinus bradycardia, tachycardia
-AV block
-Re-entry
-Atrial flutter and fibrillation
-Ventricular flutter and fibrillation
-Premature ventricular contractions (PVCs)
Term
Common Diseases Associated with Arrythmias (7)
Definition
-Hypertension
-Cardiac valve disease
-Coronary artery disease
-Low potassium levels in blood
-Myocardial infarction
-Stroke
-Diabetes mellitus
Term
What are the objectives in treating arrhythmias (4)?
Definition
1. Restore cardiac rhythm to normal
2. Prevent arrythmia recurrence
3. Decrease the hemodynamic consequences of arrhythmia
4. Reduce risk of sudden cardiac death
Term
How are arrhythmias treated (3)?
Definition
-Drug therapy
-Surgical ablation of point of origin
-Manage underlying disease
Term
What are the 4 classes of antiarrhythmic drugs?
Definition
Class 1 (A, B, and C): block fast sodium channels
Class 2: Beta blockers
Class 3: Potassium channel blockers
Class 4: Calcium channel blockers
Term
Name 2 Class 1-A Sodium Channel Blockers
Definition
-Procainamide
-Quinidine
Term
Name 1 Class 1-B Sodium Channel Blocker
Definition
Lidocaine
Term
Name 1 Class 1-C Sodium Channel Blocker
Definition
Propafenone
Term
What is the mechanism of action of the Class 1 Sodium Channel Blockers (5)?
Definition
-Block sodium channels
-Prolong AP
-Decrease conduction velocity
-Suppress abnormal automaticity of ectopic pacemakers
-Some also affect potassium channels.
Term
What are the Class 1 Sodium Channel Blockers used for (4)?
Definition
-Atrial fibrillation
-Premature ventricular contractions
-Prevention of life-threatening ventricular arrhythmias
-Not for mild arrhythmias
Term
ADRs of Class 1 Sodium Channel Blockers (11)
Definition
-May worsen existing arrhythmias
-Cinhonism (toxicity)
-Nausea
-Vomiting
-Diarrhea
-Hypotension
-Dizziness
-Confusion
-Drowsiness
-Rash
-Thrombocytopenia (low platelets)
Term
Contraindications of Class 1 Sodium Channel Blockers
Definition
-Heart block
-CHF
Term
What are the nursing considerations when administering Class 1 Sodium Channel Blockers (2)?
Definition
-Check apical pulse for 1 minute before administering
-Monitor BP
Term
Name a Class 2 Beta Blocker
Definition
Propranolol
Term
What is the mechanism of action of the Class 2 Beta Blockers?
Definition
They decrease heart rate which slows conduction in SA node and also ectopic pacemakers.
Term
What is one advantage to using Class 2 Beta Blockers?
Definition
They do not cause arrhythmias.
Term
Name 2 Class 3 Potassium Channel Blockers.
Definition
-Amiodarone (blocks potassium and calcium channels)
-Bretylium
Term
What is the mechanism of action of Class 3 Potassium Channel Blockers?
Definition
They prolong action potential usually by blocking potassium channels.
Term
What are Class 3 Potassium Channel Blockers used for?
Definition
The prevention and treatment of ventricular arrhythmias
Term
ADRs of Class 3 Potassium Channel Blockers (4)
Definition
-Neurotoxicity
-Sensitivity to UV light (amiodarone)
-Hypotension
-Risk of worsening arrhythmias
Term
Name 2 Class 4 Calcium Channel Blockers.
Definition
-Diltiazem
-Verapamil
Term
What is the mechanism of action of the Class 4 Calcium Channel Blockers?
Definition
They slow down conduction at SA and AV nodes.
Term
What are 2 Antiarrhythmics that are not included in Classes 1-4 and how do they work?
Definition
Adenosine- Adenosine Receptor Agonist that slows conduction in the SA and AV nodes and can interrupt reentry

Digoxin-Cardiac glycoside used to slow conduction through the SA and AV node
Term
What are the nursing implications when administering antiarrhythmic drugs (14)
Definition
-Check BP and apical pulse before administration
-Monitor vital signs
-Monitor ECG
-Monitor kidney, liver
-Monitor serum drug levels
-Monitor electrolyte levels
-Teach patient about SEs
-Do not stop treatment abruptly
-Evenly spaced doses
-Avoid caffeine
-Reduce CV risk factors
-Medical ID tag
-Avoid alcohol
-Take with food
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