Term
| Class I Antiarrythmics primary action |
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Definition
block fast Na channels
Used to terminate REENTRY ARRYTHMIA
Protect ventricles in SVT
Dec amplitude and rate of depol.
May create reentrant circuit |
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Term
| Class II Antiarrythmics primary action |
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Definition
| block beta-adrenergic receptors |
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Term
| Class III Antiarrythmics primary action |
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Definition
block K channels
Prolong AP duration in atrial and vent. m. and Purkinje fibers |
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Term
| Class IV Antiarrythmics primary action |
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Definition
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Term
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Definition
Quinidine
Procainimide
INTERMEDIATE dissociation
Work modestly at fast HR
Inc AV conduction velocity |
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Term
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Definition
Lidocaine
RAPID dissociation
Work well at fast HR, not at normal rate |
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Term
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Definition
Flecainide
SLOW dissociation
Work at normal and slow HR, and fast |
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Term
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Definition
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Term
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Definition
Diltiazem
Verapamil
Slows AV conduction to decrease vent rate |
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Term
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Definition
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Term
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Definition
Class IA Antiarrythmic
Oral only |
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Term
| Quinidine drug interactions |
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Definition
| doubles plasma digoxin levels |
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Term
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Definition
| muscarinic and alpha adrenergic rec blockade, inc AV conduction vel |
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Term
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Definition
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Term
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Definition
Class IA Antiarrythmic
Oral or IV |
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Term
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Definition
| Acetylated to NAPA, which blocks K channels |
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Term
| Procainamide side effects |
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Definition
Lupus-like AI synd. (ANA)
PROARRYTHMIA (TORSADES DE POINTES) |
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Term
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Definition
Class IB antiarrythmic
IV only
Used for short-term management of life-threatening ventricular arrythmias |
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Term
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Definition
Rapid hepatic
MUST BE GIVEN IV |
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Term
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Definition
Drowsiness
Tremors
Convulsions |
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Term
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Definition
Class IC antiarrythmic
Oral only
Block's a K current involved in repol. and prolongs AP |
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Term
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Definition
Propanolol
Esmolol
Decreased HR and ectopic automaticity
Enhance AV block (slow AV conduction)
Reduce contractility and O2 demand |
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Term
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Definition
Class II antiarrythmic
Non-selective beta blocker
Used for SVT and other arrythmias
Prevention of SCD in post-MI pts |
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Term
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Definition
Class II antiarrythmic
IV only
10 min half-life
For emergent circumstances |
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Term
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Definition
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Term
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Definition
Class III antiarrythmic
Used for V-tach and SVT |
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Term
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Definition
20-100 DAYS!
concentrates in tissues |
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Term
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Definition
Short term- few
Long term- potentiall fatal pulmonary fibrosis |
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Term
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Definition
Class III antiarrythmic
IV only
Prolongs AP duration via K chan. block
Emergent treatment of sustained V-fib |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Class IV antiarrythmic
Relax vascular sm m and dec arterial pressure
Baroreflex may inc HR, opposite to Rx's direct effect on sinus node
Rx supraventricular arrythmias |
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Term
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Definition
Class IV antiarrythmic
Relax vascular sm m and dec arterial pressure
Baroreflex may inc HR, opposite to Rx's direct effect on sinus node
Rx supraventricular arrythmias |
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Term
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Definition
Acts at adenosine rec
Must be given rapid IV bolus due to ultra-short half-life
Dec automaticity and inh symp effects
Slows AV conduction and inh DADs
Converts paroxysmal SVT to sinus rhythm |
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Term
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Definition
Blocks Na/K ATPase leading to SLOWED CONDUCTION and INC REFRACTORY PERIOD
Vagal stim
Used in A-fib and hrt failure |
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