Term
Name the mechanism and toxicities
Amphotericin B |
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Definition
binds ergosterol --> fungal membrane disruption and osmotic lysis of the cell
toxicities: renal (dose-dependent azotemia), acute febrile reaction, chills, anemia, inflammation of vein at IV site |
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Term
Name the mechanism and toxicities
Ketoconazole |
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Definition
mechanism: inhibits CYP-450 enzyme system --> depletion of ergosterol --> makes fungal membrane permeable
toxicities: GI probls, hepatotoxicity, inhibition of testosterone synthesis, adrenal suppression |
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Term
| This triazole is used for Candida albicans and cryptococcal meningitis |
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Definition
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Term
This triazole is useful for hisoplasmosis, coccidiodomycosis, blastomycosis, sporotichosis
has poor oral absorption, take it with Cola |
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Definition
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Term
This triazole is used for invasive aspergillus and fluconazole resistant candida
it has both oral and IV formulation
toxicities: visual changes, hepatotoxicity, rash |
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Definition
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Term
| These echinocandins are glucan synthesis inhibitors given IV as salvage for patients with invasive aspergillosis and against candida |
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Definition
| Capsofungin and micafungin |
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Term
This drug binds to ergosterol and causes cell lysis
It is too toxic to take parenterally and is only applied to skin and mucous membranes
"Swish and Swallow" |
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Definition
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Term
interferes with synthesis of and polymerization of nucleic acid
used to treat dermatophyte infections |
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Definition
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Term
deaminated to 5-fluoro-uraciil by the fungus and incorporated into RNA
used for some candida and cryptococcus infections |
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Definition
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