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Anti-Depressants
Drugs used to treat depression.
22
Nursing
Undergraduate 3
05/08/2011

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Cards

Term
What are the 5 classes of antidepressants?
Definition
Tricyclics
MAO inhibitors
SSRI's
Atypicals
SNRIs
Term
What are the major hormones involved in depression?
Definition
Serotonin
Dopamine
NE
Term
TCA's and Cardiotoxicity
Definition
TCA blocks serotonin uptake, has anti choliergic effect---cause dysrythmias.
[TACHYCARDIA]
Term
Why are TCA's used?
Definition
Refractory depression
Chronic Pain (nerve pain, migraines)
Insomnia
Term
TCAs Mechanism of Action
Definition
Blocks serotonin and NE reuptake
Term
MAO inhibitors and diet
Definition
Tyramine rich foods increase NE and can cause hypertensive crisis
Term
MAO inhibitors Mechanism of Action
Definition
Increases NE and serotonin in the CNS
Term
Why are MAOIs used?
Definition
Last line for depression
Term
What are the most prescribed classes of antidpressants?
Definition
SSRIs, SNRIs, and atypicals
Term
SSRIs mechanism of action
Definition
inhibits serotonin
Term
When are SSRIs used?
Definition
First line for depression, OCD, anxiety, panic disorder and PMDD
Term
Too much Serotonin can lead to..
Definition
Serotonin Syndrome
Term
What is Serotonin Syndrome?
Definition
"shake and bake"
-fever and tremors, confusion, hyperreflexia
-indicator of Toxicity
-Can see when adding "herbal" antidepressants and ADHD drugs
Term
Serotonin Withdrawal is due to.
Definition
Too little serotonin
Term
Serotonin withdrawal S&S
Definition
F--Flue like symptoms (aches and pains)
L--Lightheadedness
U--Uneasiness (anxious)
S--Shakiness
H--Headaches
Term
Side effect of SSRIs
Definition
Sexual dysfunction!

also..
weight gain
headache
nausea
increased risk of bleeding
Term
Nursing Care for AntiDepressants
Definition
monitor suicide risk
Term
What is Lithium used for?
Definition
Bipolar disorder
Term
Lithium mechanism of Action
Definition
Stabilizes Calcium in neuron
Term
Lithium toxicity
Definition
narrow therapeutic index
Term
Lithium drug interactions
Definition
Diuretics -- lose sodium and potassium salts and water; you retain lithium--can cause toxicity and dehydration.

NSAIDS decrease diffusion to kidneys so you retain lithium.
Term
Nursing Care with lithium
Definition
Goal: prevent dehydration and electrolyte depletion.

encourage sodium and adequate water intake to prevent toxicity.
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