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General Anesthesia
JJC Vet Tech 117
106
Veterinary Medicine
Undergraduate 1
04/14/2014

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Term
define "general anesthesia"
Definition
state of reversible unconsciousness, analgesia, amnesia, and decreased or absent reflexes
Term
define "apnea"
Definition
"without a breath;" holding the breath; temporary cessation of breathing
Term
define "nystagmus"
Definition
rapid, rhythmic, repetitious involuntary eye movements
Term
define "narcosis"
Definition
drug-induced sleep from which the P is easily aroused
Term
define "hypnosis"
Definition
sleeplike state from which P can be aroused with sufficient stimuli eg pain
Term
define "balanced anesthesia"
Definition
using 2+ drugs/anesthetics in combination to maximize benefits but not disadvantages of individual components
Term
What are the "5 Hypos"?
Definition
-hypoventilation
-hypotension
-hypothermia
-hypoxemia
-hypovolemia
Term
What is "hypoventilation"?
Definition
Breathing at an abnormally slow rate, results in hypercapnea (PaCO2 > 45 mmHg)
Term
What is "hypotension"?
Definition
Abnormally low blood pressure (MAP < 70 mmHg)
Term
There is no palpable pulse when MAP is...
Definition
< 60 mmHg
Term
What is "hypothermia"?
Definition
Abnormally low body temperature (< 99F or > 2F decrease)
Term
What is "hypoxemia"?
Definition
aka hypoxia; abnormally low O2 in the blood (PaO2 < 60 mmHg)
Term
What is "hypovolemia"?
Definition
decrease in intravascular fluid volume, ie loss of blood volume
Term
Hypovolemia is a indicator of...
Definition
poor perfusion
Term
PaO2 / PaCO2 stands for...
Definition
Partial Arterial
Term
SpO2 stands for...
Definition
Saturation Percent
Term
EtO2 stands for...
Definition
End Tidal CO2
Term
What measures blood gas?
Definition
PaCO2
Term
When and how do you measure PaCO2?
Definition
during surgery, draw blood
Term
Does the value of EtCO2 = PaCO2?
Definition
yes, because CO2 diffuses so well
Term
Does the value of SpO2 = PaO2?
Definition
no, SpO2 is a % and PaO2 is in mmHg
Term
4 traits of Ether from PP?
Definition
-prolonged recovery
-irritating to MM
-flammable and explosive
-relatively slow evaporation
Term
5 Advantages of inhalant gases:
Definition
-rapid diffusion (in blood quickly, blows off quickly)
-better control of anesthetic depth than injectables
-less metabolized than injectables
-delivered with O2
-good muscle relaxation
Term
3 Disadvantages of inhalant gases:
Definition
-expensive equipment
-increased knowledge and skill required
-health risks of exposure
Term
4 Health risks of inhalant gases:
Definition
-pregnant women
-liver/kidneys from chronic exposure
-complacency
-nausea, headaches, ataxia
Term
MAC stands for...
Definition
Minimum Alveolar Concentration
Term
MAC indicates the ___ of an inhalant gas.
Definition
potency
Term
Define MAC:
Definition
the lowest concentration of gas anesthetic within the alveoli that prevents movement in 50% of patients when pain is induced
Term
Higher solubility = ____ potency
Definition
higher solubility = higher potency
Term
higher solubility (in blood) = ____ MAC
Definition
higher solubility = lower MAC
Term
higher potency = ____ MAC
Definition
higher potency = lower MAC
Term
___ MAC numbers have a greater margin of safety.
Definition
higher MAC numbers have a greater margin of safety
Term
How does MAC affect % on the anesthetic machine dial?
Definition
Higher MAC gases require higher % given to the patient. Dials used to go to 7%, but Sevoflurane needed 8%.
Term
Most patients are maintained under anesthesia at _____ % gas.
Definition
3-4%
Term
95-98% of patients are maintained at _____ x MAC.
Definition
1.5-2 x MAC = % gas
Term
Anesthetic gases that are less soluble in blood will hit the brain ____ and blow off ____.
Definition
less blood-soluble = hit faster, blow off faster
Term
Newer gases have become more or less lipophilic?
Definition
less- new gases are more water/blood-soluble
Term
4 things that decrease the MAC:
Definition
-premeds
-local blocks
-hypothermia
-hypothyroidism
Term
3 things that increase the MAC:
Definition
-anxiety
-pain
-thyrotoxicosis
Term
Another term for hyperthyroidism?
Definition
thyrotoxicosis
Term
The "flurane" gases are considered what class of anesthetic? (chemically)
Definition
halogenated hydrocarbons
Term
Gas halogens have __ or __ in the molecule.
Definition
Br or Fl
Term
Which is more flammable: halogenated, or non-halogenated?
Definition
non-halogenated
Term
Name the gas halogens covered in class:
Definition
-methoxyflurane
-halothane
-isoflurane
-sevoflurane
Term
Advantages of Isoflurane compared to Sevoflurane:
Definition
-Iso is cheaper
-use less of it
-longer recovery (can finish stitching up, doing nails, etc)
Term
Difference in recovery times for Iso and Sevo?
Definition
Iso ~12-15 min
Sevo ~4-5 min
Term
Which gas halogen is the most nephrotoxic?
Definition
Methoxyflurane
Term
Which gas halogen is the most hepatotoxic?
Definition
Halothane
Term
What gas halogen uses a non-precision vaporizer?
Definition
Methoxyflurane
Term
Which gas anesthetic may not be available for purchase in the US, but is still used by some exotic vets?
Definition
methoxyflurane
Term
Recovery time for methoxyflurane if used on its own?
Definition
45-50 min
Term
Gas halogen with the longest induction and recovery times?
Definition
methoxyflurane
Term
Is methoxyflurane more soluble in water/blood or lipids?
Definition
water/blood
Term
Which gas halogen is the most metabolized by the body?
Definition
methoxyflurane
Term
VPC
Definition
Ventricular Premature Contraction
Term
VPCs are associated with which inhalant?
Definition
Halothane
Term
When do VPCs occur?
Definition
when halothane is mixed with epi or barbiturates, or hypoxia
Term
Which gas halogen can cause malignant hyperthermia? In what species?
Definition
halothane- humans, pigs, dogs (esp. dobes)
Term
"Malignant hyperthermia" is...?
Definition
life-threatening increase in body temperature
Term
Which gas halogen has a strong, irritating odor?
Definition
Isoflurane
Term
Nitrous Oxide is abbreviated ___.
Definition
N2O
Term
Which anesthetic gas does not have a general anesthetic effect?
Definition
N2O because MAC is too high (not water-soluble)
Term
In the tank, N2O is in what state?
Definition
liquid AND gas
Term
Which inhalant does not need a vaporizer?
Definition
Nitrous oxide
Term
What color is a N2O flowmeter?
Definition
blue/purple
Term
What is the "second gas effect"?
Definition
N2O lowers the amount of anesthetic gas used to get the same effect
Term
What is "diffusion hypoxia"?
Definition
When stopping N2O, it displaces O2 from the lungs
Term
How to prevent diffusion hypoxia?
Definition
Give 100% O2 for ~10 min after stopping N2O
Term
When using N2O, the O2 flow rate should be ___ that of N2O.
Definition
O2 flow 2x that of N2O
Term
Gas halogen with the longest induction and recovery times?
Definition
methoxyflurane
Term
Is methoxyflurane more soluble in water/blood or lipids?
Definition
water/blood
Term
Which gas halogen is the most metabolized by the body?
Definition
methoxyflurane
Term
VPC
Definition
Ventricular Premature Contraction
Term
VPCs are associated with which inhalant?
Definition
Halothane
Term
When do VPCs occur?
Definition
when halothane is mixed with epi or barbiturates, or hypoxia
Term
Which gas halogen can cause malignant hyperthermia? In what species?
Definition
halothane- humans, pigs, dogs (esp. dobes)
Term
"Malignant hyperthermia" is...?
Definition
life-threatening increase in body temperature
Term
Which gas halogen has a strong, irritating odor?
Definition
Isoflurane
Term
Nitrous Oxide is abbreviated ___.
Definition
N2O
Term
Which anesthetic gas does not have a general anesthetic effect?
Definition
N2O because MAC is too high (not water-soluble)
Term
In the tank, N2O is in what state?
Definition
liquid AND gas
Term
Which inhalant does not need a vaporizer?
Definition
Nitrous oxide
Term
What color is a N2O flowmeter?
Definition
blue/purple
Term
What is the "second gas effect"?
Definition
N2O lowers the amount of anesthetic gas used to get the same effect
Term
What is "diffusion hypoxia"?
Definition
When stopping N2O, it displaces O2 from the lungs
Term
How to prevent diffusion hypoxia?
Definition
Give 100% O2 for ~10 min after stopping N2O
Term
When using N2O, the O2 flow rate should be ___ that of N2O.
Definition
O2 flow 2x that of N2O
Term
What species are more sensitive to opioids?
Definition
horses, cats
Term
Cats require a lower dose of ____ but are more resistant to ____.
Definition
cats need less lidocaine, are more resistant to phenothiazine tranqs
Term
Acepromazine is in what class of drug?
Definition
phenothiazine
Term
___ have a rougher recovery from gas anesthetics.
Definition
horses
Term
Avoid anticholinergics in ____.
Definition
ruminants
Term
Why are ruminants at risk of aspiration?
Definition
they can regurgitate at any time
Term
___ are more sensitive to xylazine, needing 1/10th the dose of ___, and are more prone to ___.
Definition
Ruminants, require 1/10 dose of horse, prone to bloat
Term
___ and ___ tend to have more airway secretions.
Definition
cats and ruminants
Term
Smaller animals are more at risk of hypoxia and hypercarbia because...
Definition
more dead space in breathing tubes
Term
The most commonly used injectable anesthetic in all species is...
Definition
ketamine
Term
Dogs may seizure if ____ is not combined with a ____.
Definition
dogs may seizure if ketamine not combined with sedative (like Valium)
Term
Cats can tolerate a ____ agent like ___ on its own.
Definition
dissociative agent like ketamine
Term
Larger animals are more prone to what conditions when anesthetized?
Definition
dependent atelectasis and pressure necrosis
Term
What breeds are more sensitive to barbiturates?
Definition
sighthounds (eg greyhound)
Term
What breeds are more sensitive to acepromazine? More resistant?
Definition
sensitive = boxers, lg breeds
resistant = terriers
Term
What challenge might we face as techs when prepping a brachiocephalic breed?
Definition
-harder to intubate
-may need smaller ET tube
Term
What type of horse is more sensitive to sedatives?
Definition
draft (big guys like Clydesdale)
Term
Stallions may develop what condition if acepromazine is used?
Definition
penile prolapse
Term
What drug should be avoided in cows and sheep? When and why?
Definition
xylazine, in late pregnancy it can cause uterine contractions ==> abortion
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