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Anatomy Viscera
Medical School Anatomy and Histology flashcards for thorax, abdomen, pelvis, perineaum and reproduction + endocrine histo
317
Anatomy
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09/17/2011

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Term
vertebral level of left kidney
Definition
T11-L3
Term
vertebral level of right kidney
Definition
T12-L4
Term
rib articulation with vertebrae
Definition
superior articular facet of rib = articulates with the inferior costal facet of vertebra above it
inferior articular facet of rib = articulates with superior costal facetown vertebrae
tubercle of rib = articulates with the transverse process of its own rib
Term
which muscle is located between the subclavian artery and vein, as they run over the 1st rib?
Definition
anterior scalene muscle
Term
is the joint between rib 1 and sternum synovial
Definition
no, fibrocartilaginous connection
Term
TTP
Definition
Transverse thoracic plane (T4-5)
- separates superior and inferior mediastinum
- marks the superior border of the pericardium
- marks the starting point for the arch of the aorta (supine position)
- bifurcation of the trachea
- superior to the pulmonary trunk
Term
superior angle of the scapula
Definition
T2
Term
inferior angle of the scapula
Definition
T7
Term
Spine of the scapula
Definition
T3
Term
jugular notch
Definition
T2-3
Term
where does breast cancer develop
Definition
cells of the acini
lactiferous ducts
lobules of the breasts
Term
which nerves can be damaged in a radical masectomy?
Definition
long thoracic = winged scapula
thoracodorsal = affects actionsof the latissimus dorsi
Term
flow of milk through the breasts
Definition
secretory lobules --> lactiferous ducts --> lactiferous sinuses --> nipple
Term
nipple location and innervation
Definition
location = 4th intercostal space
innervation = 2nd-6th intercostal nerves
Term
pectoralis major muscle
Definition
origin = medial 1/2 of clavical, sternum and costal cartilage
insertion = lateral lip of intertubercular sulcus of the humerus
action = adducts, flexes and medially rotates the humerus
innervation = lateral and medial pectoral nerve
Term
pec minor
Definition
origin = ribs 3-5
insertion = coracoid process
action = pulls the tip of the shoulder inferiorly (supports the shoulder)
innervation = medial pectoral nerve
Term
other muscles that contribute to respiration
Definition
scalene muscles
posterior serratus muscle
deep back muscles
Term
borders for the "safe triangle" when placing a chest tube
Definition
latissimus dorsi
pec major
apex of the axilla
Term
structures that pass through the diaphragm at T8
Definition
inferior vena cava
right phrenic nerve
pericardiacophrenic artery
Term
structures that pass through the diaphragm at T10
Definition
esophagus
vagus nerve
Term
structures that pass through the diaphragm at T12
Definition
thoracic aorta
throacic duct
Term
vertebral location of the hilum of the lung
Definition
T5-7
Term
costomediastinal recess
Definition
most medial recess
Term
costodiaphragmatic recess
Definition
most inferior recesses
location = 6, 8 and 10th ribs (medial --> lateral)
Term
lung innervation
Definition
parasymphathetic = vagus nerve
sympathetic = from sympathetic trunks
Term
innervation of the fibrous pericardium
Definition
phrenic nerve (C3-5)
vagus nerve (CN10)
sympathetic trunks
Term
innervation to the whole pericardium
Definition
vagus nerve (CN10)
phrenic nerve (C3-5) = carries somatic afferent fibers (referred pain to C3-5 dermatomes)
sympathetic trunks
Term
Kussmaul's sign
Definition
when the jugular venous pulse does not go away upon inspiration
seen in constrictive pericarditis (abnormal thickening of the pericardial sac)
Term
diastole (what happens to the heart)
Definition
relaxation and filling
openings to the coronary arteries are not blocked (are open)
Term
heart valve incompetence (insufficency)
Definition
poorly functioning valve
Term
heart valve stenosis
Definition
stenosis = narrowing of the orfice because the valve cannot open fully
Term
sytole (what happens to the heart)
Definition
contraction of the heart (both atria and ventricles)
opening to the coronary arteries are blocked
Term
vertebral level of the bifurcation of the trachea
Definition
T4-5
Term
medial border of the scapula
Definition
with arm abducted:
- lies along the 6th rib
- marks the approximate location of the oblique fissure of the lung
Term
manubrium
Definition
T3-4
Term
body of the sternum
Definition
T5-9
Term
apex of the heart
Definition
5th intercostal space
referred to as the "point of maximum impulse" of heart
Term
median arcuate ligament of diaphragm
Definition
attaches the diaphragm to the posterior wall of the thoracic
T12-L1
Term
parasympathetic innervation to the heart
Definition
run with the vagus nerve
decrease heart rate, force of contraction and constric coronary arteries
cholinergic
Term
ligamentum arteriosum
Definition
connects the aorta to the pulmonary veins (CT band in adults)
during fetal development, shunts the blood from the pulmonary veins to the aorta because mom was oxygenating the blood
Term
innervation of the esophagus
Definition
vagus nerve and sympathetic turnks
sensory innervation = vagus nerves, sympathetic trunks and splenchnic nerves
pain = sympathetic turnks and splanchnic nerves (NOT vagus)
upper 1/2 of esophagus = recurrent laryngeal nerves
lower 1/2 of esophagus = esophageal plexus (from right and left vagus nerves)
- anterior vagal trunk = supplies anterior surface of esophagus (from left vagus nerve)
- posterior vagal trunk = supplies posterior surface of esophagus (from right vagus nerve)
Term
arteries and veins of the esophagus
Definition
esophageal arteries (from the thoracic aorta)
azygous vein and hemiazygous vein
Term
to which vein does the thoracic duct drain
Definition
left brachiocephalic vein
Term
three major splanchnic nerves
Definition
greater splanchnic (T5-9) --> celiac ganglion
lesser splanchnic nerve (10-11) --> aorticorenal ganglion
least splanchnic nerves (12) --> renal plexus
Term
lumbar lymph nodes consist of which nodes
Definition
preaortic lymph nodes
lateral aortic lymph nodes
preaortic lymph nodes
Term
transverse pericardial space
Definition
space that you can put your fingers in during surgery to clamp off the aortic vessels. Found between the pulmonary veins.
Term
apex of the heart
Definition
fifth intercostal space
Term
what it the most prominent layer of an artery?
characteristics?
Definition
tunica media
concentric layers of smooth muscle and elastic fibers
reticular fibers (collagen Type III)
proteoglycans
Term
what separates the media from the intima in arteries
Definition
internal elastic lamina
Term
which cells synthesize the ECM in blood vessels
Definition
smooth muscle cells
Term
which cells synthesize the ECM in blood vessels
Definition
smooth muscle cells
Term
what is the most prominent layer in veins
Definition
tunica adventitia
CT (type I collagen)
elastic fibers
smooth muscle
arranged longitudinally
Term
what underlies the endocardium?
Definition
subendocardium (underlies endothelial lining)
Term
in what layer of the heart are purkinje fibers located?
Definition
endocardium (subendocardium)
Term
how are the layers of the myocardium arranged?
Definition
inner = circular
outer = longitudinal
Term
what structures differentiate myocardium from other layers of the heart?
Definition
intercalated discs
lipofuscin
Term
the epicardium makes up what layer of the pericardium specifically?
Definition
visceral layer of the serous pericardium
Term
what is the difference in location of the internal elastic lamina/membrane when you compare elastic and muscular arteries
Definition
elastic arteries = found in the tunica media and tunica adventia
muscular artery = prominent in the tuninca intima only
Term
what does PDGF (platelet-derived growth factor) do?
Definition
smooth muscle cell proliferation --> implicated in atherosclerosis
Term
what are the differentiating characteristics between arteries and arterioles?
Definition
arterioles:
- thin subendothelium
- invisible internal elastic lamina
- media is much smaller (1-2 layers)
- very thin adventitia
Term
differentiate between the three types of capillaries
Definition
continuous = somatic capillaries, tight junctions (CNS, PNS, muscle, endocrine, CT)
fenestrated = visceral capillaries (glomerulus of kidney, median eminence)
sinusoidal = discontinuous capillaries (liver, lymphodi, spleen)
Term
do venules have valves?
Definition
no
Term
differentiate between venules, veins and large veins
Definition
venules = very thing walls
veins = thin intima and media, very big adventia
large veins = thick intima, thin media, very big adventitia
Term
are olfactory epithlium the same as respiratory epithelium?
Definition
they are both pseudostratified columnar but olfactory epithelium act very differently
Term
why are olfactory cells considered bipolar?
Definition
apical surface = have olfactory cells and vesicles with non-motile cilia
basal surface = gives rise to axons that form the olfactory nerve (CN1)
Term
what type of tissue if found in the epiglottis?
Definition
elastic cartilage
Term
what are the two surfaces of the epiglottis? what type of epithelium does each have?
Definition
lingula surface (facing the tongue) = statified squamous epithelium
laryngeal surface = pseudostratified columnar with cilia
Term
what are the three laryngeal cartilages?
Definition
thyroid, cricoids, arytenoids
Term
what are brush cells and where are they found?
Definition
sensory cells found in the olfactory segment of the narynx as well as in the trachea
Term
what cells and tissues make up the lamina propria of the trachea
Definition
loose CT
basement membrane
mast cells
macrophages
plasma cells
lymphoid tissue
Term
do primary bronchi have c-shaped cartilage?
Definition
yes
replaced by irregular plates of cartilage when they enter the lungs and become secondary bronchi
Term
how can you distinguish between the bronchi and bronchioles?
Definition
bronchi = have cartilage
bronchioles = have thick smooth muscle in place of cartilage and NO subepithelial glands
Term
where are clara cells found and what do they secrete?
Definition
in the bronchioles
secrete lipoprotein to prevent adhesion of the adjacent walls during expiration and Clara cell protein (CC16) = secreted when lung is damaged
Term
which three structures make the pulmonary acini? Describe the progression.
Definition
terminal bronchiole --> repiratory bronchiole --> alveoli
(outside to inside the lung)
Term
what is the smallest functional unit of the pulmonary structure?
Definition
pulmonary acini
Term
what causes cystic fibrosis?
Definition
autosomal recessive disorder
genetic defect of Cl- channel protein = decreased Cl- = increased Na+ = increased water reabsorption in the lungs = thicker mucus = bronchioles are abstructed
Term
alveolar duct vs. alveolar sac
Definition
duct = elongated airway with almost no walls
sac = spaces surrounded by clusters of alveoli
Term
what are lamellar bodies and where are they found?
Definition
found in type II pneumocytes
contain phospolipids and surfactant
Term
respiratory distess syndrome
Definition
lack of surfactant and the alveoli would collapse on exhalation
seen in premature babies who have not yet developed their respiratory system
Term
Goodpasture syndrome
Definition
antibodies made to type IV collagen
affect the basal lamina of the alveolar septum
common in males average age 29
Term
alveolar macrophages
what happens when they are "full"?
Definition
in the CT of air spaces
called "dust cells"
scavenge the surface of epithelium and remove inhaled particulates
when full = are swept up in mucus and expelled by coughing
Term
what are the permanent changes in COPD
Definition
alveoli are permanently dilated and alveolar walls are destroyed
Term
processus vaginalis
Definition
formed from the peritoneal outpouching; facilitates the descent of the gonads
Term
what does the transversalis fascia add to the spermaticord?
Definition
internal spermatic fascia
Term
what does the external oblique add to the spermaticord as it passes through the inguinal canal?
Definition
external spermatic fascia
Term
what does the internal oblique become in the spermaticord?
Definition
cremasteric muscle
Term
what does the gubernaculum become in the male adult form?
Definition
ligament that holds the testis in the scrotom
Term
what does the gubernaculum become in the adult female?
Definition
round ligament of the uterus
ligament of the ovary
Term
what passes through the inguinal ligament in both men and women?
Definition
both = genitalfemoral nerve and ilioinguinal nerve
men = spermaticord
woman = round ligament
Term
superificial ring is an evagination of which structure?
Definition
external oblique
Term
what makes up the conjoint tendon?
Definition
combined tendons of the transversus abdominis and the internal oblique
Term
where is the deep inguinal ring located?
Definition
the beginning of the inguinal canal;
lateral to the inferior epigastric vessels
Term
the deep inguinal ring is and evagination of what structure?
Definition
transversalis facia
Term
components of the superficial inguinal ring
Definition
pubic crest
medial and lateral crura = cross to prevent further widening of the ring
Term
boundaries of the inguinal canal
Definition
anterior wall = aponeurosis of the external oblique (plus some internal oblique)
posterior wall = transversalis fascia (reinforced by conjoint tendon)
floor = medial 1/2 of the inguinal ligament
roof = arcs of the transversus abdominis and the internal oblique muscles on their way to form the conjoint tendon
Term
structures found in the spermaticord
Definition
ductus deferens
artery to the ductus deferens
testicular arteries
pampiniform plexus of veins
cremasteric artery and vein
genital branch of the genitofemoral nerve
sympathetic branch of the genitofemoral nerve
lymphatics
remnants of the processus vaginalis
Term
cremasteric reflex
Definition
sensory nerves of the ilioinguinal nerve (L1) are activated --> genital branch of the genitofemoral nerve is stimulated (L1-L2) --> testicals are pulled closer to the body by the cremasteric muscle
you can elicit this reflex by stroking the upper medial thigh
Term
which type of hernia is most commonly seen in males?
Definition
indirect
enters deep inguinal ring and can go all the way through the canal, out the superficial ring and down to the scrotum or labia majorum
congenital (processus vaginalis does not close all the way)
Term
Hesselbach's triangle
Definition
common location for direct hernias, medial to the inferior epigastric muscles
medial border = rectus abdominis
lateral border = inferior epigastric muscles
inferiorly = inguinal ligament
Term
innervation of the genitalia
Definition
sympathetics from T10-11
vagus nerve (sympathetics and visceral nerve)
Term
what is the difference between metastases of scrotal and testicular cancer?
Definition
scrotal = to superficial inguinal nodes
testicular = to lumbar nodes
Term
variocele
Definition
veins do not drain in the scrotum
"bag of worms"
Term
which nerve is prone to damage during hernia surgeries?
Definition
ilioinguinal nerve(lose sensation in the thigh and scrotum)
femoral branch of the genitofemoral nerve
Term
muscles that make up the posterior abdominal wall
Definition
quadratus lumborus
psoas major
iliacus
Term
which muscles make up the anterior abdominal wall?
Definition
transversus abdominis
internal oblique
external obliqe
rectus abdominus
Term
vertebral level of the umbilicus
Definition
L3-4
Term
four transverse planes and their vertebral location
Definition
transpyloric plane (L1)
subcostal plane (L3)
umbilical (L3-4)
supracristal (L4)
transtubicular (L5)
Term
which fascia is famous for liposuction?
Definition
camper's (superficial to Scarpa's)--cannot suture, very vascularized
Term
in which fascia does the deep, visceral fat of the abdomen reside?
Definition
extraperitoneal fascia
Term
what fascia does Scarpa's fascia turn into when it passes into the anterio part of the perineum?
Definition
Scarpa's fascia --> Colle's fascia --> tunica Dartos of the scrotum and superifical penile fascia
Term
median umbilical fold
Definition
remnant of the urachus (urine drainage in the fetus)
Term
medial umbilical folds
Definition
obliterated fetal umbilical arteries (2-one on each side)
Term
lateral umbilical folds
Definition
located over the inferior epigastric vessels (2= one each side)
Term
innervation of the parietal peritoneum and the anterior abdominal wall
Definition
T7-L1
Term
how are the muscle sheaths arranged above the arcuate line?
Definition
anterior = external oblique and 1/2 internal oblique
posterior = 1/2 internal oblique, transversus abdominis and transversalis fascia
Term
how are muscles arranged below the arcuated line?
Definition
anterior = external and internal oblique, transversus abdominis
posterior = transversalis fascia
Term
which vessels run between the transversalis facia and the rectus abdominis muscle?
Definition
inferior epigastric vessels
Term
what forms the inguinal ligament?
Definition
inferior margin of the external oblique
Term
what makes up the posterior wall of the rectus sheath?
Definition
transversus abdominis aponeurosis
transversalis fascia
Term
foramen of windslow
Definition
opening to the lesser sac (omental bursa)
located just posterior to the stomach and portal triad
Term
why is the hepatoduodenal ligament considered surgically important?
Definition
you have to be careful not to cut it because it contains the portal triad
Term
intraperitoneal organs
Definition
gastric section of the esophagus, stomach, first part of the duodenum, ileum, jejunum?, cecum, transverse colon, liver, spleen, and tail of the pancreas
Term
retropertoneal organs
Definition
kidneys, adrenal glands, rectum, abdominal aorta, IVC
Term
secondarily retroperitoneal
Definition
rest of the duodenum (except the first part), pancreas (except the tail), ascending and descending colon, sigmoid colon
Term
what are the remnants of the ventral mesentery in the adult?
Definition
faliciform ligament
lesser omentum
Term
what are the remnants of the dorsal mesentery in adults?
Definition
gastrocolic ligament
gastrosplenal ligament
splenorenal ligament
mesentery of the small intestines
sigmoid mesocolon
Term
which mesenteries make up the lesser and greater curvature of the stomach, respectively?
Definition
greater curvature = dorsal mesentery
lesser curvature = ventral mesentery
Term
which arteries supply the foregut, midgut and hindgut?
Definition
foregut = celiac trunk (T12/L1)
midgut = superior mesenteric (L1)
hindgut = inferior mesenteric (L3)
Term
what vertebral level is the rectosigmoid junction found?
Definition
S3
Term
vertebral levels of the parts of the duodenum
Definition
superior part (L1)
descending part (L1-3)
inferior part (L3)
ascending part (L3-2)
Term
major duodenal papillae
Definition
common entrance for the bile duct and the pancreatic duct (sphincter of Oddi here)
Term
minor duodenal papilla
Definition
where the accessory pancreatic duct drains into the duodenum
Term
ligament of Treitz
Definition
suspensory muscle (ligament) of the duodenum
skeletal muscle (no smooth muscle)
Term
which structure marks the junction between the foregut and the midgut?
Definition
Amupulla of Vater
Term
location of the spleen
Definition
ribs 9-11
Term
ligaments of the diaphragmatic surface of the liver
Definition
coronary sinus
right and left triangular ligaments
Term
falciform ligament
Definition
ligament that divides the lobes of the liver and attaches the liver to the anterior abdominal wall
derived from ventral mesentery
Term
ligamentum teres
Definition
obliterated left umbilical vein
continuation of the falciform ligament
Term
porta hepatis
Definition
portal triad:
- bile duct
- hepatic artery proper
- portal vein
Term
biliary tree
Definition
right and left hepatic ducts --> common hepatic duct + cystic bile duct --> bile duct --> ampulla of Vater --> sphincter of Oddi --> major duodenal papilla --> duodenum
Term
arterial supply of the gallbladder
Definition
right hepatic artery
Term
innervation of the foregut
Definition
T6-9
pain = sympathetics (thoracic splanchnics)
parasympathetics = vagus
Term
plicae circularis
Definition
prominent folds int he jejunum and ileum
Term
jejunum v. ileum
Definition
jejunum = larger diameter, thicker walls, more numerous folds, less prominent arterial archades and longer vasa recta
ileum = thinner walls, fewer and less prominent folds, more arterial arcades, shorter vasa recta
Term
Peyer's patches
Definition
found only in the ileum
antimesenteric (?)
Term
arterial supply of the cecum and appendix
Definition
anterior and posterior cecal artery (sup. mes)
appendicular artery (sup. mes)
Term
arterial supply of the ascending colon
Definition
right colic artery (superior mes)
middle colic artery (sup. mes)
left colic artery (inf. mes)
Term
arterial supply of the descending colon
Definition
left colic artery (inf mes)
Term
arterial supply to the sigmoid colon
Definition
sigmoidal artery (inf mes)
Term
arterial supply to the rectum and anal canal
Definition
superior, middle and inferior rectal arteries (inf. mes)
Term
marginal artery
Definition
an artery that connects the superior and inferior mesenteric arteries; gets bigger during atherosclerosis when one of them gets blocked
Term
Hirschsprung's disease
Definition
congenital megacolon; does not work properly because there is a failure of neural crest cells into the distal colon
Term
tunica vaginalis
Definition
remnant of the processa vaginalis that is located in the anterolateral part of the testes
Term
four portal-caval anastomoses
Definition
paraumbilical
esophageal veins
veins of the anal canal
retroperitoneal veins with the abdominal wall (minor)
Term
venous drainage of the rectum
Definition
superior rectum = drains to the inf. mes
middle and inferior rectum = drains to internal iliac arteries
Term
major thigh flexor
Definition
psoas major
iliacus (hip flexor)
Term
musculotendinous crura
Definition
anchors the diaphragm to the lumbar vertebrae
Term
median ligament
Definition
connects the crura of the diaphragm
passes anterior to the aorta and makes the aortic hiatus
Term
location of the domes of the diaphragm
Definition
left dome = fifth intercostal space
right dome = rib 5
Term
arterial supply to the diaphragm
Definition
superiorly (thoracic supply)
- pericardiophrenic arteries (internal thoracic)
- musculophrenic arteries (int. thor.)
- superior phrenic artery (thoracic aorta)
inferiorly (abdominal supply):
inferior phrenic arteries (abdominal aorta)
Term
vertebral level where the renal arteries come off the abdominal aorta
Definition
between L1 and L2
Just below the TTP
Term
the right renal artery passes posterior to which structure?
Definition
IVC
Term
location of the ureter in both males and females
Definition
ureter runs under the vas deferens in males and under the uterine artery
Term
arteries that supply the ureters
Definition
upper = renal arteries
middle = abdominal aorta, testicular and ovarian arteries, common iliac arteries
in pelvic cavity = internal iliac branches
Term
innervation of the kidneys
Definition
least and lesser splanchnics
T10-L1 (visceral afferents)
Term
referred pain when passing a kidney stone
Definition
T11-L2
loin to groin
Term
arterial supply of the adrenal glands
Definition
superior adrenal arteries (from inferior phrenic arteries)
midle suprarenal artery (from aorta)
inferior suprarenal artery (from renal)
Term
innervation of the adrenal medulla and cortex
Definition
medulla = sympathetics from greater splanchnic (NO PARASYMPATHETICS)
cortex = no innervation
Term
bifurcation of the abdominal aorta
Definition
L4
Term
paired branches of the abdominal aorta
Definition
middle suprarenal arteries
renal arteries
testicular or ovarian arteries
Term
posterior branches of the aorta
Definition
lumbar --> posterior abdominal wall and spinal cord
median sacral --> anterior surface of the sacrum and coccyx
Term
where do the inferior phrenic arteries arise from the aorta?
Definition
T12 (aortic hiatus)
Term
what is Triple A
Definition
Abdominal Aortic Aneurism
great redicular artery comes off the aorta (at T12-L1), during repair of the AAA, it can be damaged and can cause spinal cord ingury (in lumbar area)
Term
formation of the IVC
Definition
L5
Term
veins that drain into the IVC
Definition
common iliacs
renal veins
lumbar veins
inferior phrenic veins
hepatic veins
hemiazygous
accessory hemiazygous
azygous
Term
where does the portal vein form?
Definition
at the level of the transpyloic plane (L1)
Term
location of the inferior mesenteric arteries
Definition
subcostal plane (L3)
Term
nerves that come off the lumbosacral plexus
Definition
obturator (L2-4)
femoral (L2-4)
genitofemoral (L1-2)
lateral femoral cutaneous (L2-3)
ilioinguininal (L1)
iliohypogastric (L1)
Term
what are the four distinct layers of the digestive tract?
Definition
mucosa
submucosa
muscluaris externa
adventitia or serosa
Term
what type of tissue makes up the lamina propria of the GI tract?
Definition
loose CT
blood vessels
lymphatics
nerves
lymphoid tissue
glands
Term
which organs are outgrowths of the duodenum
Definition
liver
pancreas
gallbladder
Term
three layers of the mucosa
Definition
epithlium with basement membrane
lamina propria
muscularis mucosa
Term
arrangement of the layers of the GI muscularis mucosa
Definition
inner circular
outer longitudinal
Term
tissue that composes the submucosa
Definition
dense irregular CT
blood vessels
lymphatics
Meissner's plexus
Term
from where is the epithelium of the mucosa derived
Definition
endoderm
Term
from where is Meissner's plexus derived?
Definition
neural crest
Term
location of Meissner's plexus
Definition
submucosa
Term
location of Auerbach's plexus
Definition
in between the smooth muscle layers of the muscularis externa
Term
from where is Auerbach's plexus derived?
Definition
neural crest
Term
what is the difference between serosa and adventia
Definition
both outermost layer of GI tubes
serosa = makes up the visceral peritoneum in intraperitoneal organs and continuous with the mesentery
adventia = surrounds retroperitoneal organs and attaches them to the abdominal wall
Term
5 types of gastric epithelial cells
Definition
surface cells
undiffernetiated cells
mucous neck cells
parietal cells
cheif cells
Term
what do oxyntic cells secrete? what else do they do?
Definition
intrinsic factor (vitamin B12 absorption)
**elaborate HCl secretion
Term
are parietal cells acidophilic or basophilic?
Definition
acidophilic
Term
are zymogenic cells acidophilic or basophilic?
Definition
basophilic
Term
what does vitamin B12 deficiency present as in early and later stages?
Definition
CNS degeneration
presents as diabetic neuropathy and then MS
Term
which layer of the stomach makes the pyloic sphincter?
Definition
middle circular layer of the muscularis externa
Term
plicae circulares
Definition
in the small intestine
called valves of kerkring
has a core of submucosa
Term
villi of the small intestine
Definition
core of lamina propria
has central lymphatic vessel or lacteal
Term
Crypts of Leiberkun
Definition
intestinal glands within the lamina propria of the small intestine
Term
paneth cells
Definition
in the base of the crypts of leiberkuhn
contain eosinophilic granules with antibacterial enzymes
Term
enterocytes
Definition
epithelial cells with microvilli
found in the small intestine
Term
enteroendocrine cells
Definition
secrete CCK (inhibits gastric emptying)
secrete GIP (decrease acid in the stomach
secrete secretin (pancreatic secreation and inhibits gastric acid)
Term
M cells
Definition
modified enterocytes that cover lymph nodules in the lamina propria of the small intestine
present antigens to lymphoid tissue
Term
Brunner's glands
Definition
found in the submucosa of the duodenum
secrete alkaline secretion to buffer acidic chyme (optimize pH for pancreatic enzymes)
Term
what tissue makes up the external anal sphincter
Definition
skeletal muscle
Term
what intervates the external anal sphincter
Definition
inferior anal (rectal) nerve
- branch from the pudendal nerve (S2-4)
Term
Fundis vs. pyloris
Definition
fundis = short pits, deep glands
pyloris = deep pits, short glands
Term
atrophic gastritis
Definition
affects the efficiency of the parietal cells to secrete interic factor = causes B12 deficiency = can cause pernicious anemia
Term
blood proteins synthesized by the liver
Definition
albumin
fibrinogen
lipoprotein
Term
zone 3
Definition
zone of the liver closest to the central vein
furthest away from the portal triad
first to show ischemic necrosis
last to respond to toxins
Term
bile caniculi
Definition
carry the bile in the opposite direction as the blood
have no walls
tight junctions
Term
components of bile
Definition
bile acids
phopholipids
cholesterol
bilirubin
water
Term
cell type of bile ductules
Definition
cuboidal
Term
cell type of bile ducts
Definition
columnar cells
Term
Rokitansky-Aschoff sinuses
Definition
deep invaginations of the gallbladder
indicate pathologic changes
Term
secretions of the pancreatic acini
Definition
proteases
lipases
nucleases
Term
what stimulates pancreatic acini
Definition
CCK (from enteroendocrine cells)
parasympathetic (vagus) stimulation
Term
cells of intercalated ducts
Definition
cuboidal cells
Term
interlobar ducts
Definition
columnar cells
Term
white pulp
Definition
spleen
lymphoid nodules
B-cells (provides immune surveillance)
Term
red pulp
Definition
acts as filters and degrades old red blood cells--traps them and recycle hemoglobin
t-cells
Term
within which structure does the gallbladder form?
Definition
ventral mesentery
Term
columns of Bertin
Definition
cortical tissue found between the medullary pyramids of the kidney
Term
duct of Bellini
Definition
ducts formed when several collecting ducts come together
also called papillary ducts
Term
most important layer of the filtration barrier. other barriers?
Definition
basement membrane = most important
endothelial cells of glomerular capillaries (with fenestrated capillaries)
podocyte (filtration slits and diaphragms)
Term
layers of the glomerular basement membrane
Definition
2 lamina rarea (anionic heparine sulfate) = charge barrier
lamina densa (in between lamina rarea layers) = collagen type IV (physical barrier) --> protein 69kDa (size of albumin)
Term
mesangial cells
Definition
synthesizes extracellular matrix
support the capillaries of the glomerlus
phagocytotic = keep the filtration barrier CLEAN
may be contractile
Term
primary cause of renal disease
Definition
glomerular injury
- immune (antibodies)
- non-immune (hypertension)
Term
function of the proximal convoluted tubule
Definition
absorption
85% sodium
100% glucose, amino acids and small proteins
Term
function of the distal convoluted tubule
Definition
absorb soduium
secrete = potassium, hydogren and ammonium ions (adjust pH)
Term
juxtaglomerular cells
Definition
smooth muscle cells of afferent arteriole
systhesize and release reninin
Term
function of JG
Definition
regulates blood pressure
Term
macula densa of the kidney
Definition
modified portion of the distal convoluted tubule
columnar cells with tightly packed nuclei
monitors NaCl concentration in the tubular fluid
regulates glomerular filtration rate (GFR)--> release reninin from JG cells
Term
where is angiotensin I converted to angiotensin II
Definition
endothelium of the lungs
Term
ACE
Definition
angiotensi converting enzyme
increases BP
Term
structures that go through greater sciatic foramen
Definition
piriformis
sciatic nerve
superior and inferior gluteal nerves
posterior femoral cutaneous nerve
pudendal nerve
internal pudendal artery and vein
Term
structures that pass through the lesser sciatic foramen
Definition
tendon of the obturator internus
pudendal nerve
internal pudenal artery and vein
Term
which structures pass through the greater and the lesser sciatic foramen
Definition
pudendal nerve
internal pudendal artery and vein
Term
obturator internus
Definition
origin = internal surface of the rim of the obturator foramen
insertion = greater trochanter
innervation = nerve to obturator interus (L5-S1)
aciton = laterally rotates extended hip and abducts flexed hip
Term
piriformis
Definition
origin = sacrum
insertion = greater trochanter
innervation = nerve to the piriformis (S1-S2)
action = laterally rotates extended hip and abducts flexed hip
Term
coccygeus muscle
Definition
origin = ischial spine
insertion = coccyx and border of sacrum
innervation = anterior rami of S3-4
action = pooping muscle
Term
levator ani muscle
Definition
origin = pubic bone, ischial spine
insertion = superior surface of the perineal body
innervation = S4 and inferior rectal branch of pudendal nerve (S2-4)
Action = supports pelvic floor
Term
pelvic diaphragm
Definition
makes up the floor of the pelvic cavity
levator ani and coccygeus composes it
Term
muscles near the openings of perineal membrane in females
Definition
deep transverse perineal muscle
sphincter urethrovaginalis
compressor urethrae
external urethral sphincter
Term
muscles near the opening of the perineal membrane in males
Definition
external urethral sphincter
deep transversalis perineal
Term
pectinate line
Definition
line in the anal canal
where the endoderm and ectoderm meet
where visceral and somatic sensory afferents meet
Term
arterial supply to the anal canal
Definition
superior rectal (inferior mesenteric)
middle rectal (internal iliac)
inferior rectal artery (internal pudendal from internal iliac)
Term
sympathetic innervation of the bladder
Definition
from inferior thoracic and upper lumbar levels
Term
pain afferents for bladder
Definition
superior part of the bladder = travels with sympathetics (T11-L3)
inferior part of bladder = travels with parasympathetics
Term
pain line of bladder
Definition
line dividing superior and inferior part of the bladder (pain travels with sympathetics and then parasympathetics in inferior part)
Term
parts of the male urethra
Definition
preprostetic urethra
prostetic urethra (ejaculatory duct)
membranous urethra (bulborethral glands)
spongy urethra (in corpus spongiosum of penis)
Term
innervation of the testes
Definition
T10-12
Term
to which lymph nodes do the testes drain?
Definition
lumbar nodes (lateral and preaortic)
Term
arteries to testes
Definition
testicular artery (L2) = just inferior to the renal arteries
Term
which veins drain the testes
Definition
left testicular vein --> left renal
right testicular vein --> IVC
Term
the seminal vesicles develop from an outgrowth of which structure?
Definition
vas deferens
Term
cavernous nerves
Definition
on the fibrous capsule of the prostate
innervate = erectile tissue of the penis
Term
seminal colliculus
Definition
the elevated portion of the urethral crest where the two ejaculatory ducts and the prostatic utricle open in the prostetic urethra
Term
which part of the prostate is affected by BPH
Definition
transitional zone and then periurethral zone
Term
three parts of the broad ligament
Definition
1. mesometrium (mesentery for uterus)
2. mesosalpinx (in between the mesovarium and uterine tubes)
3. mesovarium (suspends the ovaries)
Term
uterine tube blood vessels
Definition
ovarian vessels
uterine vessels
vaginal artery
internal pudendal artery
Term
lymph drainage to the ovaries
Definition
lumbar nodes
Term
lymph drainage to middle and upper vagina, cervix and body of uterus
Definition
internal iliac nodes
Term
lymph drainage to the superolateral uterus
Definition
superficial inguinal nodes
Term
lymph drainage of the osteum of the vagina
Definition
superficial inguinal nodes
Term
pudendal nerve
Definition
S2-4
supplies entire perineum
Term
pelvic splanchnics
Definition
parasympathetic (S2-4)
Term
sacral splanchnics
Definition
sympathetic
pregangliionic (L1-2)
postganglionic (sacral sympathetic trunks)
Term
which major arteries supply the pelvis and perineum?
Definition
internal iliac artery
-posterior division
-anterior division
Term
what contains the ovarian vessels
from where do they come
Definition
suspensory ligament of the ovary contains the ovarian vessels
right ovarian vein --> IVC
left ovarian vein --> left renal vein
right and left ovarian arteries <-- abdominal aorta (L2)
Term
Colles's fascia
Definition
found in the perineum
membranous layer of superficial fascia
continuous with Scarpa's facia
continues to become Dartos fascia of the scrtoum
Term
Buck's fascia
Definition
deep fascia of the penis
Term
erectile tissue in males
Definition
2 crura of the corpora cavernosa --> 2 corpora cavernosae in the penis
corpus spongiosum
bulb of the penis
Term
erectile tissue of the female
Definition
crus of the clitoris
bulb of the vestibule
glands clitoris
greater vestibular glands (Bartholin glands)
Term
vessels and nerves of the superficial perineal space
Definition
internal pudendal vessels
pudendal nerve
Term
Gallaudet's fascia
Definition
investing fascia associated with erectile tissue (superficial transverse perineal muscles)
Term
muscles associated with erectile tissue
Definition
superficial trnasverse perineal muscle
ischiocavernosus muscles
bulbospongiosus muscle
Term
tunica albuginea
Definition
surrounds the 2 corpora cavernosa in the penis
Term
erection is what type of reflex?
innervation?
Definition
sacrospinal reflex
afferent: perineal nerve <-- pudendal nerve (S2-4)
efferent: parasympathetic travel int he pelvic splanchnics
Term
nerves involved in ejaculation
Definition
sympathetic (L1)
- cause peristalsis to move semen to prostatic urethra

parasympathetics (S2-4)
- contraction of the urethral smooth muscle

somatic reflex (pudendal nerve S2-4)
- contraction of bulbospongiosum
Term
Dartos fascia
Definition
layer of smooth muscle that covers the scrotum (fat free)
maintains temperature of the testes
Term
innervation of the scrotum
Definition
anterior scrotal nerve <-- ilioinguinal and genitofemoral nerve
posterior scrotal nerve <-- pudendal
Term
innervation of the labia majora
Definition
anterior labial nerves <-- ilioinguinal nerve
posterior labial nerves <-- superficial perineal nerve
Term
innervation of the urethral sphincter
Definition
deep perineal nerve <-- pudendal nerve (S2-4)
Term
tunica propria
Definition
surrounds the semiferous epithelium
contains 3-5 layers of myoid (peritubular cells)
Term
phases of the spermatid phase
Definition
transformation to become sperm
1. golgi phase (acrosomal vesicle forms near head)
2. cap phase (formation of the war head)
3. acrosomal phase (sperm reorient themselves to embed themselves into the sertoli cell)
Term
how do steriods affect the testes
Definition
blocks LH production in the pituitary --> testes shrivel
Term
Leydig cells
Definition
make testosterone
under the influence of LH
Term
sertoli cells
Definition
helper cells
secrete = Androgen-binding protein and inhibin
postmitotic
columnar cells
exceedingly tight juctions
form blood-testis barrier
Term
ABP
Definition
androgen-binding protein
secreted by sertoli cells
converts estrogen to testosterone
Term
corpora amylacea
Definition
concretions in the prostate that form over time (calify)
Term
secretions of the prostate
Definition
citric acid
fibrinolysin
serine protease (PSA)
Term
arteries that supply the penis
Definition
helicine arteries <-- deep artery of penis <--internal pudendal artery
Term
Batson's plexus
Definition
venous route where prostate cancer metastasizes to the vertebral column
Term
theca interna cells
Definition
produce androgens under the influence of LH
Term
granulosa cells
Definition
convert anderogens to estrogen
under the influence of FSH
Term
LH surge
Definition
day 13 of cycle
causes oocyte to resume first meiotic division --> ovulation occurs 12-24 hours later
Term
maculla pellucida
Definition
region around the graafian follicle that becomes ischemic right before the secondary oocyte is released from the ovary
Term
function of the corpus luteum
Definition
secretes estrogen and progesterone that prepare and maintain the development of the endometrial line
Term
atretic follicle
Definition
a follicle that is degenerated by programmed cell death
Term
phases of the menstrual cycle
Definition
proliferative phase (estrogen)
- follicular phase
secretory phase (progesterone)
- luteal phase
menstrual phase (decrease in both)
- corpus luteum
Term
vagina is influenced by which hormone
Definition
estrogen
Term
which hormone rises under the influence of LH
Definition
progesterone
Term
which uterine phase begins shortly after the hormonal surge on day 13
Definition
secretory phase
Term
three types of hormones
Definition
peptide (small)
steriods
- secreted by the gonad and adrenal cortex
amino acid anaologues and derived
- catecholamines
- secreted by some neurons and the adrenal medulla
Term
hormones released by the adenohypophysis
Definition
ACTH
TSH
FSH
LH
GH
Prolactin
Term
Three cell types in adenohypophysis
Definition
acidophils (40%)
- somatotropes = GH
- lactotropes = prolactin
basophils (10%)
- gonadotropes = FSH, LH
- coticotropes = ACTH
- thyrotropes = TSH
chromophobes (50%)
Term
median eminance
Definition
fenestrated capillaries
no blood=brain barrier
located at the top of the pituitary gland near the infundibulum and stalk
Term
hypothalamus hormones
Definition
somatostatin
dopamine
TRH
GHRH
CRH
GnRH
Term
from where is the neruohypophysis derived
Definition
neuroectoderm of the developing diencephalon
Term
neurohypophysis hormones
Definition
oxytocin
ADH
**only stored here
Term
from where is the adenohypophysis derived
Definition
Rathke's pouch, an evagination of the developing oral cavity ectoderm
Term
brain sand
Definition
calfied concretions in the pineal body
Term
what does the pineal gland secrete
Definition
melatonin
Term
cells of parathyroid
Definition
chief cells
oxyphil cells
Term
zones of the adrenal cortex
Definition
zona glomerulosa (inner)
- secrete mineralcorticoids = aldosterone (middle)
zona fasciculata
- secrete glucocorticoids
zone reticularis (outer)
- secrete gonadocorticoids = DHEA
Term
cells and secretions of 3 pancreas cells
Definition
beta cells (70%) = insulin
alpha cells (15-20%) = glucagon
delta cells (5-10%) = somatostatin
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