Term
|
Definition
Myeloblasts without granules
Type 1 Blasts
Cytochemical stains are negative
CD12, CD33, CD34
Rare (5% of AML's) |
|
|
Term
| AML-M1 with Minimal Maturation |
|
Definition
Most common AML
Found in both adults and infants
Type 1 and 2 blasts, 90% are non-erythroid
Positive sudan black B and peroxidase
Trisomy 8
t(9;22)
t(6;9)
Decreased platelets
Normocytic, normochromic anemia |
|
|
Term
|
Definition
Promyelocytes and Myelocytes
Auer Rods
Phi Bodies
Positive myeloperoxidase, sudan black B, and chloroacetate esterase
t(8;22)
90% blasts, Types 1 and 2
Leukapheresis
Most common AML in adults |
|
|
Term
|
Definition
aka Promyelocytic Leukemia
Seen in young adults and the elderly
Promyelocytes, Hypergranular or Hypogranular
Faggot cells
30% blasts
Positive peroxidase, sudan black B, chloroacetate esterase, and nonspecific esterase
t(15;17)
Folded Nuclei
Hypogranular Cytoplasm
Metachromatic Granules
Bleeding
Retinic Acid and Heparin Therapy |
|
|
Term
|
Definition
aka Acute Myelomonoblastic Leukemia
aka Maegali Type
>30% blasts, Type 1 and 2
Promyelocytes and Monoblasts
Pseudo-Pelger-Huets
Hypogranular Neutrophils
Monocyte count: >5
Increased Eosinophils
Positive peroxidase, sudan black B, chloroacetate esterase, and nonspecific esterase |
|
|
Term
|
Definition
aka Acute Monoblastic Leukemia without Differentiation
aka Shilling Type
Monoblasts with lacy, nuclear chromatin
Decreased platelets
Pseudo-Pelger-Huets
WBC Count: 5-20
>80% monoblasts
Positive nonspecific esterase
Myeloperoxidase and sudan black B can be positive or negative
Weakness, bleeding, skin rashes
Rapidly fatal |
|
|
Term
|
Definition
aka Acute Monoblastic Leukemia with Differentiation
More mature monocytes |
|
|
Term
|
Definition
aka Erythroblastic Leukemia
aka Diguglielmo Syndrome
Positive myeloperoxidase, sudan black B, and a-naphthyl acetate esterase
Decreased LAP score
Bleeding
CD71
Glycophorin A positive |
|
|
Term
|
Definition
aka Megakaryocytic Leukemia
aka Acute Malignant Myelosclerosis
aka Acute Myelodysplasia with Myelofibrosis
aka Acute Myelofibrosis
Increased megakaryoblasts
Positive nonspecific esterase and chloroacetate esterase
Dry Taps
Positive platelet peroxidase
CD41 and CD 61
Abnormalities in chromosome 21 |
|
|
