Term
| What is the mechanism of amiodarone? |
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Definition
| Class III anti-arrhythmic blocker: blocks K channel (some B-Blocker activity). Prolongs action potential duration. |
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Term
| How does amiodarone affect CYP enzymes? |
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Definition
| Enzyme inhibitor (2C9 -amitryptyline; warfarin(S); Statins: fluvastatin, rosuvastatin; sulfonyurea: glibenclamide, gliclazide, glimeripide; phenytoin. |
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Term
| What drugs inhibit amiodarone metabolism |
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Definition
| CYP3A4/5; "AVIRs": ritonavir, saquinavir, "AZOLEs: ketoconazole, itraconazole; grapefruit juice; MACROLIDEs: erythromycin, clarithromycin |
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Term
| Amiodarone inhibits P-glycoprotein. What drugs may increase in concentration because of this? |
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Definition
| cyclosporin, digoxin, clopidogrel |
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Term
| What are the counselling points for amiodarone? |
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Definition
| Avoid sun exposure; Interacts with grapefruit juice; Regular blood test, ECGs, chest X-rays; Tell doctor shortness of breath, dry cough, vision problems, weight loss, muscle weakness; Perform eye examination annually |
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Term
| What are the serious side effects associated with amiodarone? |
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Definition
| Pulmonary toxicity, neurotoxicity, benign corneal microdeposits, skin pigmentation. |
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