Term
| A primary chronic, neurobiologic disease with genetic, psychosocial and environmental factors influencing its development and manifesteations |
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Definition
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Term
| Maladaptive patter of substance us e characterized by repeated adverse consequences related to the repeated use of the substance |
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Definition
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Term
| State of adaptation that is manifested by a drug class specific withdrawal syndrome that can be produced by abrupt cessation, rapid dose reduction, decreasing blood level of drug, administration of antagonist |
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Definition
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Term
| state of adaptation in which exposure to a drug induces changes that result in a diminuition of one or more of the drug's effects over time |
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Definition
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Term
| Addiction is characterized by______ |
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Definition
| Chronicity, compulsion, craving (as well as impaired control over drug use and continuing despite harm) |
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Term
| T/F slow onset BZDs are preferred as party drugs because of prolonged effects |
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Definition
| False; fast onset (such as diazepam) are preferred as they are reinforcing |
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Term
| T/F withdrawal can be fatal |
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Definition
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Term
| T/F switching PT to another BZD (that is a current BZD abuser) will decrease the pattern of drug abuse and dependence |
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Definition
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Term
| Why should BZD withdrawal PTs be tapered? |
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Definition
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Term
| T/F an antidote does not exist for GHB, and only supportive care is possible |
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Definition
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Term
| T/F Opiate withdrawal can be fatal |
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Definition
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Term
| What should alcohol withdrawal be treated with? |
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Definition
Lorazepam (2mg q1h, taper). Prevent seizures, use higher initial dose. and taper over 7-10 d.
Chlordiazepoxide |
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Term
| For what reason might BZDs be underdosed in those undergoing alcohol withdrawal? |
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Definition
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Term
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Definition
| Lorazepam 2mg 3-4x/d; taper 5-7 days (ADDITIONAL 5-7 d if long acting) |
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Term
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Definition
Methadone (20-80mg. taper 5-10mg/d)
Buprenorphine (4-32 mg/d)
Clonidine (2mcg/kg tid 7d, taper 3d) |
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Term
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Definition
| bromocriptine (2.5mg tid, reduces cravings) |
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Term
| What are the 3 drugs for EtOH dependence? |
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Definition
| Disulfuram, Naltrexone, Acamprosate |
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Term
| which drug causes an averse reaction to alcohol? |
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Definition
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Term
| which drug inhibits aldehyde dehydrogenase, resulting in acetaldehyde to accumulate? |
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Definition
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Term
| _______is rarely but potentially hepatotoxic |
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Definition
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Term
| Which drug is an opiate antagonist, and attenuates the effects of alcohol? |
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Definition
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Term
| ______ causes dose related hepatotoxicity and nausea |
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Definition
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Term
| Which drug reduces cravings and is a glutamate modulator at the NMDA receptor? |
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Definition
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Term
| Which 2 drugs for alcohol dependence are used together for maintaining alcohol abstinence? |
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Definition
| acamprosate and naltrexone |
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