Adrenergic Agonists are aka sympathomimetics.  Why?

Because they mimic effects caused by the sympathetic nervous system

What are the two chemical classes of adrenergic agonists?

1.  Catecholamines

2.  noncatecholamines

3 Catecholamine agonists characteristics:

1.  Taken orally only

2.  Brief duraction of action

3.  Can't cross blood-brain barrier - polar molecules

3 Noncatecholamine adrenergic agonists characteristics:

1.  Can be taken orally

2.  Can cross the blood-brain barrier

3.  Longer duration

Activation of alpha1 receptors cause:

1.  Mydriasis

2.  vasoconstriction

3. Increased PR

4. increased bladder control

What are alpha1 agonists used for?

1.  hemostasis

2.  nasal decongestion

3. hypotension

4. adjunct to local anesthesia

What are the 2 major adverse effects of alpha1 activaton?

1.  hypertension

2.  local necrosis (if extravasation occurs)

All of the clinically significant responses to activatoin of beta1 receptors result from activating beta1 receptors in the heart.

True or False

True

Activation of beta1 receptors cause what?

1.  Increased HR

2.  increased force of contraction

3.  Increased AV conduction

4. Increased release of renin

Drugs that activate beta1 can be used for:

1.  Heart Failure

2.  AV Block

3.  Cardiac Arrest caused by asystole

4.  Shock

3 Potential adverse effects of beta1 activation are:

1.  Tachycardia

2.  dysrhthmia

3.  angina

Drugs that activate beta 2 receptors are used primarily for what?

Asthma

2 major adverse effects from activation of beta 2 receptors?

hyperglycemia (esp in dm patients)

tremor

Activation of dopamine receptors does what?

dilates renal bloos vessles, which helps maintain renal perfusion during shock

What is the catecholamine that activates beta1, beta2, alpha1, and alpha2

Epinephrine

Epinephrine is the drug of choice for treating anaphylactic shock. Why?

What else does it treat?

Stimulates alpha1, beta1, and beta2 receptors so can elevate BP, suppress glottal edema, and counteract bronchoconstriction

Cardiac Shock

Prolongation of local anesthetic

What are the primary things treated by alpha2 

Hypertension 

Beta 1 and beta2 agonists stimulate what?

beta1 - cardiac, kidney

beta2 l - lungs, arterioles, uterus, liver, skeletal muscle

Fight or Flight

In the sympathetic nervous system, the fight or flight mechanism stimulates what?

1. dilate pupils

2. dilate bronchioles

3. inc rate and force of heart

4. dilate blood vessels in muscle tissue

5.  constrict visceral blood vessels

6. glycogenolysis

List the catecholamine adrenergic drugs?

1.  Epinephrine

2.  Norepinesphrine

3.  Isoprotenol

4.  Dobutamine

5.  Dopamine

List the noncatecholamine adrenergic agonists.

1.  Ephedrine/pseudophedrine

2. Phenylephrine

3. Terbutaline