Term
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Definition
Endogenous glucocorticoid produced in the zona fasiculata
Short acting; 1:1 GR to MR |
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Term
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Definition
| Long acting powerful glucocorticoid used initially treat atopic dermatitis |
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Term
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Definition
| Long acting powerful glucocorticoid used in the treatment of acute adrenal insufficiency along with isotonic NACL Glucose and Cardiac monitoring |
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Term
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Definition
Intermediate strength and acting glucocorticoid given in morning to avoid HPA axis supression.
used in treatment/management of:
1. Poisen Ivy
2. Chronic Adrenal insufficiency
3. Rheumatic disease management
4. Giant Cell Arteritis
5. IBD (inflam Bowel diseas)
Avoid Phenytoid, rifampin, barbituates |
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Term
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Definition
| Intermediate strength Intermediate lasting water/lipid soluble glucocorticoid used in the treatment of osteoarthritis or INTRALESIONAL SKIN DISORDERS |
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Term
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Definition
Bodies mineralcorticoid produced in the zona glomerulosa that resorbs Na/h20 and pushes out K/H in response to angiotensin 2 and hyperkalemia.
CAN CAUSE CARDIAC/VASCULAR FIBROSIS |
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Term
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Definition
used as aldosterone replacement therapy for:
1. Congential adrenal hyperplasia
2. chronic adrenal insufficiency (CYP21 mutation = excess hydroxypregnsone) |
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Term
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Definition
CYP11B = last step before cortisone development. used to
1. Test HPA axis to determine if ACTH dependant
2. Treat ectopic ACTH or adrenal neoplasms |
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Term
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Definition
#1 drug used for the treatment of cushings DISEASE
higher doses than for anti-fungal inhibits CYP17 = hydroxypregnalone half |
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Term
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Definition
| CYP11A (directly from cholesterol) inhibitor. used to treat cushings. Poses as risk of developing acute adrenal insufficiency. |
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Term
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Definition
| 11B-HSD2 inactivates cortisol into cortisone at sights such as the kidney. Reactivates at other sites via 11BHSD1. |
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Term
| Toxicity glucocorticoids and withdrawl |
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Definition
1. myopathy
2. osteonecrosis/osteoporosis (inhibits gonadal hormones)
3. increased glucose
4. cataracts
5. flare-ups when removed
6. adrenal insufficiency when removed |
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Term
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Definition
Betametasone = class 1
hydrocortisone = class 7 |
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Term
| CYPS and what not to remember |
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Definition
1. CYP21 = congenital adrenal hyperplasia which yields excess hydroxypregnasone
2. CYP11A = aminoglutethimide = stops at cholesterol
3. CYP11B = Metyrapone = stoppage last step
4. CYP17 = stops before hydroxypregnasone
5. 11BHSD2 = cortisol to cortisone |
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