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Adrenergic Antagonist
Review
40
Medical
08/16/2011

Additional Medical Flashcards

 


 

Cards

Term
What is another name for adrenergic blockers?
Definition

sympatholytic drugs

Term

What is the actions of 

Adrenergic Antagonists?

Definition

Direct blocking action on alpha or beta receptors and reduce action of endogenous norepinephrine or adrenergic agonists

Term

What is the indirect action of

Adrenergic Antagonists?

Definition

act on postganglionic nerve terminal and decrease NE content and/or release of NE resulting in reduced response

Term
Where do alpha antagonist bind?
Definition

a1 – postsynaptic

a2 mostly presynaptic

Term
What is the action of alpha antagonist?
Definition

reduce NE release

Term

What is the action of Prazosin?

 

Definition

 

block a1

 

Term

What is the action of tamsulosin?

 

Definition
block a1
Term

What is the action of doxazosin?

 

Definition
block a1
Term
What is the action of Phentolamine?
Definition

 

blocks a1 and a2, competitive, short acting

 

Term
What is the action of Phenoxybenzamine?
Definition

blocks a1 + a2; reacts chemically, irreversible, long-acting

Term
What effect does blockade of postsynaptic a1 causes in cardiovascular system and blood vessels?
Definition

 

arterial/venous vasodilation, reduced blood pressure, some reflex tachycardia

 

Term
What effect does blockade of a1 and a2 have on cardiovascular and blood vessel?
Definition

causes more marked vasodilation, hypotension and marked tachycardia, relaxation of sphincter muscle of bladder and capsule of prostate; headache; decrease cholesterol and triglycerides

Term
How do b1 and b2 differ?
Definition

differing in 1 amino acid and differ in the blockade effects of beta blockers

Term

How do beta blockers block b1 and b2 receptors?

 

Definition
Competitively
Term

What is the action of Propranolol?

 

Definition
b1 and b2 blocker
Term

What is the action of timolol?

 

Definition
b1 and b2 blocker
Term

What is the action of nadolol?

 

Definition
b1 and b2 blocker
Term

 

What is the action of Metoprolol?

 

Definition

Beta 1 blocker

Term
What is the action of Atenolol?
Definition

Beta 1 blocker

Term

What is the action of Acebutolol?

 

Definition

 

Beta 1 blocker

 

Term
What is the action of Labetalol?
Definition

blocks alpha and beta receptors

Term

 

What action does Beta blocker with intrinsic sympathomimetic activity

 

Definition

It acts like a partial agonist that

blocks or stimulates depends on activity certain activity

 

Term

What is the action of Pindolol?

 

Definition
Beta blocker with intrinsic sympathomimetic activity
Term

What is the action of carteolol?

Definition
Beta blocker with intrinsic sympathomimetic activity
Term
What are the effects of beta blocker?
Definition

Reduces heart rate, contractility, conduction, blood pressure, lowering of blood glucose, prolonged hypoglycemia

 

 Local anesthetic effect, bronchial constriction; fatigue, other.

 

  

Term
When is beta blocker contraindicated?
Definition

Contraindicated in heart block and congestive heart failure.

Term
How can b blocker temporarily increase perioheral resistance?
Definition

 

due to beta blockade in blood vessels

 

Term
In which case scenario is effects of beta blockers more pronounced?
Definition
in cases of increased blood pressure and/or heart rate.
Term
What is withdrawal syndrome?
Definition

Stopping prolonged medication therapy abruptly, causing up-regulation of beta receptors

Term
What are the therapeutic use of adrenergic antagonist?
Definition

a) Chronic Hypertension

 

 

 

b) Anxiety related tachycardia, hyperthyroidism

c) Dysrhythmias

d) Angina, myocardial infarction

 

e) Pheochromocytoma

f) Open-angle glaucoma

g) Impaired bladder emptying, benign prostate hypertrophy

h) Raynaud’s disease

i) migraine

j) tremors

Term
How is chronic hypertension treated with adrenergic antagonist?
Definition

Reduction of peripheral resistance

Reduction of cardiac output

Reduced renin secretion

Term

How is anxiety related tachycardia, hyperthyroidism treated with adrenergic antagonist?

 

Definition

 

Reduction in heart rate

 

Term

How is dysrhythmia treated with adrenergic antagonist?

 

Definition

 

Reduction of excessive or abnormal pacemaker activity and other cardiac abnormalities

 

Term
How is Angina, myocardial infarctiontreated with adrenergic antagonist?
Definition

 

Reduce heart rate, contractility and O2 demand

 

Term
How is Pheochromocytomatreated with adrenergic antagonist?
Definition

 

Counteract excessive EPI levels due to adrenal tumor

 

Term
How is Open-angle glaucoma  treated with adrenergic antagonist?
Definition

 

Reduce beta induced inflow of ocular fluid at ciliary processes

 

Term
How is Impaired bladder emptying, benign prostate hypertrophytreated with adrenergic antagonist?
Definition

Relax alpha controlled sphincter muscle, bladder neck and prostate capsule

 

Term
How is Raynaud's disease treated with adrenergic antagonist?
Definition

 

Relax constriction of blood vessels

 

Term
What are the adverse effects of alpha blockers?
Definition

Postural hypotension, miosis, nasal stuffiness, GI stimulation, inhibition of ejaculation

Term
What are the adverse effects of beta blockers?
Definition

Bradycardia, sedation, congestive heart failure (rare), orthostatic hypotension, GI stimulation (and inhibition), increase in air way resistance (bronchoconstriction, dyspnea, asthma), blood dyscrasias (rare), hypoglycemia,

masking of hypoglycemic crisis, masking hyperthyroidism, cold extremities in sensitive individuals, withdrawal syndrome after abrupt cessation