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Term
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Definition
methylphenidate
d is more active than l
blocks NE and DA reuptake and increase synaptic NE/DA transmission
t1/2: 1 to 2 hours
degraded by plasma esterases to PPA (90% excreted) |
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Term
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Definition
dexmethylphenidate
active enantiomer of amphetamine (the 'd' enantiomer)
same activity as other stimulants |
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Term
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Definition
amphetamine
indirect sympathomimetic
stimulates an increase in NE transmission |
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Term
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Definition
lisdexmefatamine
prodrug
requires metabolism to become active
forms the lysine and dextro amphetamine components
lower risk of abuse |
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Term
| primary metabolite of methylphenidate |
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Definition
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Term
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Definition
atomoxetine
SNRI (R (-) enantiomer)
notice that it has two aryl groups
an ether
and long alkyl chain with terminal N
looks a lot like an SSRI
low risk of abuse, treatment of ADHD in adults/children >6 |
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Term
 imagine this molecule with an OH at the para position on the bottom "phenyl" group
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Definition
4-hydroxyatomoxetine
active metabolite of atomoxetine (about as equal)
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Term
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Definition
| an inactive metabolite of atomextine (loss of n-methyl substituent) |
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Term
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Definition
modafinil
antinarcoleptic agent
perhaps increases DA transmission/blocks reuptake
not necessarily known MoA
can cause severe rash
scheduled medication (C iv)
potential risk of abuse
marketed by Cephalon |
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Term
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Definition
amodafinil
antinarcoleptic agent
perhaps increases DA transmission/blocks reuptake
less potential SEs of modafinil
increased potency (therefore lower dose = same effect)
scheduled medication (C iv)
potential risk of abuse
marketed by Cephalon |
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Term
atomoxetine characteristics:
absorption
activity
metabolism and metabolites
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Definition
atomoxetine characteristics:
absorption: full large, well absorbed
activity: active plus 4-hydroxy metabolite active (the N-demthyl product is not)
metabolism and metabolites: aromatic hydroxylation to 4-hydroxy and N-demeth to N-des"" product that is least active |
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