Term
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Definition
The body's ability to recognize anddefend itself against distinct invaders and their products.
-Specialized immune response
-Always specific |
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Term
-Specificity
-Inducibility
-Clonality
-Unresponsiveness to self
-Memory |
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Definition
| Five attributes of Adaptive Immunity |
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Term
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Definition
Property of Adaptive Immunity:
Can only act against one particular shape and not others |
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Term
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Definition
Property of Adaptive Immunity:
Cells can get activated only in response to specific pathogens |
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Term
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Definition
Property of Adaptive Immunity:
Cells can proliferate to form many generations of identical cells called clones |
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Term
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Definition
Property of Adaptive Immunity:
Cells are self tolerant |
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Term
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Definition
Property of Adaptive Immunity:
Adaptive response has "memory" about specific pathogens; i.e. it responds faster in subsequent encounters (B cells and T Cells) |
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Term
B Lymphocytes (B Cells)
T Lymphocytes (T Cells) |
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Definition
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Term
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Definition
- Mature in the bone marrow
-Always produce antibodies |
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Term
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Definition
-Mature in the thymus
-Always produce T-Cell Medciated Response |
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Term
-Humoral immune responses
-Cell mediated responses |
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Definition
| Two Types of Adaptive Immune Responses |
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Term
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Definition
| -Mediated through B cells which secrete antibodies that acta against extracellular pathogens |
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Term
| Cell-mediated immune responses |
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Definition
| Mediated through T cells (helper t-cells and cytotoxic t-cells) which primarily act against intracellular pathogens |
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Term
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Definition
-Screen the tissues of the body for foreign antigens
-Composed of lymphatic vessels. cells, tissues, and organs
-Only carried toward heart |
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Term
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Definition
Colorless, watery liquid with similar composition to blood plasma
Arises from fluid leaked from blood veses into surrounding tissues
TOWARD HEART |
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Term
-Red bone marrow (B cells formed)
-Thymus (T cells formed) |
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Definition
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Term
-Lymph nodes (B cells)
-Spleen (b and t cells)
-Tonsils (b and t cells)
-Mucosa associated lymphatic tissue (MALT) |
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Definition
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Term
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Definition
Any foreign substance recognized by the body as worthy of attack
-Large proteins and glycoproteins
-Components of microbes
-Food & Dust |
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Term
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Definition
| Bind to three dimension regions on B or T cells, that are specific to one antigen |
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Term
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Definition
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Term
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Definition
| Intracellular, then presented on surface of cell |
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Term
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Definition
| Self antigens, present in autoimmune disorders |
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Term
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Definition
-Found in spleen, lymphnodes, and MALT
-Small percentage of memory cells circulate in the blood
-Secrete antibodies |
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Term
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Definition
-Multiple copies on cell surface
-Single BCR during development
-Only recognizes one epitope |
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Term
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Definition
-Similar in structure to BCRs
-Secreted by activated B Cells (plasma cells)
-Have identical antigen binding sites and antigen specificity as BCR of the plasma cells |
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Term
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Definition
| first antibody produced, pentamer |
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Term
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Definition
| Most common and longest lasting antibody |
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Term
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Definition
| Associated with body secretions |
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Term
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Definition
| involved in response to parasitic infections and allergies |
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Term
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Definition
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Term
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Definition
Produced in red bone marrow and matures in the thymus
-Antigen binding sites are complementary to epitopes
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Term
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Definition
-DO NOT RECOGNIZE EPITOPES DIRECTLY
-Only binds to epitopes associated w/ a MHC protein
-Against INTRACELLULAR pathogens |
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Term
-Cytotoxic T Lymphocytes
-Helper T Lymphocytes
-Regulatory T Lymphocytes |
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Definition
| Three types of T lymphocytes |
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Term
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Definition
| -Directly kills other cells |
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Term
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Definition
-Helps regulate activities of B cells and cytotoxic T cells
-Don't directly kill stuff |
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Term
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Definition
| Represses adaptive immune responses |
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Term
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Definition
| Soluble regulatory proteins that act as intercellular signals amongst cells of the immune system |
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Term
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Definition
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Term
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Definition
| Antiviral proteins that may act as cytokines |
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Term
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Definition
| Stimulate stem cells to divide |
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Term
| Tumor necrosis factor (TNF) |
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Definition
| Secreted by macrophages and T cells to kill tumor cells and regulate immune responses and inflammtion |
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Term
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Definition
| Chemotactic cytokines that signal leukocytes to move |
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Term
-Interleukins
-Interferons
-Growth Factors
-Tumor Necrosis Factors
-Chemokines |
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Definition
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Term
| Major Histocompatibility Complex |
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Definition
| Cluster of genes which determine compatability amongst grafts. |
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Term
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Definition
Found of cytoplasmic membranes of all nucleated cells
Endogenous antigens load onto MHC class I antigens |
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Term
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Definition
Found only on B lymphocytes and antigen presenting cells
Exogenous agents are phagocytosed by APCs and then displayed on the cell surface by MHC class II |
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Term
-Microphages
-Dendritic Cells
-B Cells |
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Definition
| What are the Antigen Presenting Cells? |
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Term
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Definition
Some activated T cells become memory T cells
Persist for months or years in lymphoid tiisues
Immediately functional upon contact with epitope |
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Term
| T-independant humoral immunity |
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Definition
| Dont' need helper T cells, but is weak and disappears quickly |
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Term
| T-dependant humoral immunity |
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Definition
| Require assitance of helper T cells, mediated by cytokines |
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Term
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Definition
-Activated B cells
-Only secrete antibody molecules complementary to the specific antigen
-Short lived, die w.in few days of activation, but antibodies and progeny can persist |
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Term
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Definition
-Initiates antibody production if antigen is encountered again
-Longlived |
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Term
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Definition
| -Response against antigens encountered in daily life |
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Term
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Definition
| -Antigens introduced via a vaccine |
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