Term
| what is more common AML or ALL? |
|
Definition
| AML almost twice as many diagnosed |
|
|
Term
| what are common symptoms of acute leukemia? |
|
Definition
bone pain/bleeding (dec platelets), anemia *decreased rbcs), infection b/c decreased neutrophls.
leukostasis --> causes sludging b/c immature/blasts are stickier. plug up capilliaries.
SOB, dyspnea, DIC |
|
|
Term
| T/F you can see DIC w/ acute leukemia? |
|
Definition
|
|
Term
| what are the 3 main categories of acute leukemias? |
|
Definition
|
|
Term
| in adults or high risk people with ALL what is additional chemo therp tx to give? |
|
Definition
| antracycline + cyclophosamide |
|
|
Term
| what is used for leptomenigeal relapse? |
|
Definition
|
|
Term
| what are prognosis from best to worse for ALL in terms of mutations |
|
Definition
| etv6-CBFA2--> e2A-PBX --> BCR/ABL --> MLL rearrangement |
|
|
Term
| what bcr/abl mutation is exclusive to all? |
|
Definition
|
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