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Abnormal Leukocyte Morphology
Abnormalities or variations in WBC Morphology
42
Veterinary Medicine
Undergraduate 2
06/24/2013

Additional Veterinary Medicine Flashcards

 


 

Cards

Term

"Old Blood" that has been left to sit

Increased Cortisol levels over a long period of time

(Chronic Stress)

Definition
What causes hypersegmentation of neutrophils?
Term
"Vague" blue dots
Definition
What do Dohle bodies look like?
Term

1:  <1-2 per 100 cells

2:  Rarely Seen

Definition

What are the normal amounts of band neutrophils in:

1:  Small Animal

2:  Large Animal

Term

1:  76%

2:  17%

3:  2%

Definition

What is the normal percent of neutrophils with:

1:  2-3 lobes

2:  4 lobes

3:  5 lobes

Term

1:  more commonly seen

2:  seen in extremely serious infection

Definition

How often is neutrophil toxicity seen in:

1:  Cats/Horses?

2:  Dogs/Cattle?

Term
Activated Lymphocytes
Definition

[image]

What type of variation do these WBCs exhibit?

Hint:  They are not Monocytes

Term

Activated Lymphocytes

(Reactive Lymphocytes)

(Stimulated Lymphocytes)

Definition
Lymphocytes that are responding to infection
Term

All neutrophils look similar to bands

"Kidney" shaped nucleus

"False Left Shift"

Definition
How do you recognize Pelger-Huet anomaly neutrophils?
Term
Antigenic Stimulation
Definition
What causes activated lymphocytes?
Term

Any Species

 

Definition

In which species can degranulated eosinophils occur?

 

Term
Atypical Cell
Definition

Any cells which are not normal

Cannot be readily classified

 

Term
Band Neutrophil
Definition

[image]

Name the WBC on the Right.

Term
Band Neutrophils
Definition

Immature neutrophils

Nucleus shaped like a band, sausage, "C" or "U"

 

Term

Cancer/Leukemia

Reaction to Inflammation

Other disease processes

Definition
What are the causes of atypical cells?
Term
Cytoplasm is more "Blue" than normal
Definition
What does cytoplasmic basophilia look like?
Term

Cytoplasm looks "Foamy"

(bubbles)

Definition
What does cytoplasmic foaminess look like?
Term
Cytoplasmic Basophilia
Definition

[image]

What sign of neutrophil toxicity does the cell with the black arrow pointing to it have?

Term

Cytoplasmic Basophilia

Cytoplasmic Foaminess

Dohle Bodies

Definition
How can you recognize neutrophil toxicity?
Term
Degenerative Left Shift
Definition

What is it called when neutrophils are being killed off faster than they can be made?

(decreased WBC count, increased # of bands)

Term
Degranulated Eosinophil
Definition

[image]

What type of WBC abnormality is this?

Term
Degranulated Eosinophils
Definition

Eosinophils that have no granules left

vacuoles may be left in their place

Term

Dohle Body

Neutrophil Toxicity

Definition

[image]

What is the dot that the arrow is pointing to called?

What is the term for abnormality of this cell?

Term
Greyhounds
Definition
In which breed of dog are degranulated eosinophils common?
Term
Hypersegmentation of Neutrophils
Definition
Shift in the normal # of nuclear "lobes" in neutrophils
Term
Hypersegmentation of Neutrophils
Definition

[image]

 What is the term for this WBC abnormality?

Term

Increased Basophilia of Cytoplasm

Cells are Larger with more Cytoplasm

Nuclear Chromatin are more Clumped

Definition
How do you recognize activated lymphocytes?
Term
Inflammation
Definition
What are the causes for the appearance of band neutrophils?
Term

Lipemia

Trauma (to cells)

Neoplastic or other Fragile Cells

Definition
What causes smudge cells?
Term

More than 3 cells have 5 lobes

or

more than 1 cell has 6 or more lobes

Definition
When do you report that there is hypersegmentation of neutrophils?
Term
Neutrophil Toxicity
Definition

What is it called when neutrophils are struggling to fight an infection?

("stressed")

Term
Pelger-Huet Anomaly
Definition
A congenital "defect" in which there is hyposegmentation of the neutrophils' nucleus.
Term
Pelger-Huet Anomaly
Definition

[image]

What type of WBC abnormality is this?

Term
Report as "Degranulated Eosinophils"
Definition
How do you report the presence of degranulated eosinophils?
Term

Report as "Other"

Send smear to Pathologist for Review

Definition
How do you report the presence of atypical cells?
Term

Report as "Smudge Cells Present"

or

"Broken Cells Present"

Definition
How do you report the presence of smudge cells?
Term

Report as "Suspect Activated Lymphocytes"

Send to the Pathologist for evaluation

Definition
How do you report activated lymphocytes?
Term

Report as "Suspected Pelger-Huet Anomaly"

Send to the pathologist for evaluation

Definition
How do you report a Pelger-Huet anomaly?
Term

Report as part of the 100 cell differential

"Left Shift"

Definition
How do you report the presence of band neutrophils?
Term

Smudge Cell

(Basket Cell)

Definition

[image]

What type of cell is the arrow pointing to?

Term

Smudge Cells

(Basket Cells)

Definition

Obviously broken cells

Presence of Pink "basket-like" material

Term
State the form of toxicity observed
Definition
How do you report neutrophil toxicity?
Term

nucleus is often less segmented

cell size is slightly larger

 

Definition
How do you differentiate a degranulated eosinophil from a neutrophil?
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