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A&D 2010: Mycology
Both lectures
90
Medical
Professional
01/31/2007

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Term
Only type of fungal infection that can be spread from person to person
Definition
Dermatophytic/superficial
Term
What type of conidia does Sporothrix schenckii have?
Definition
Microconidia
Term
How do you treat Sporothrix schenckii?
Definition
Daily potassium iodide; for relapsed and pulmonary cases, use amphotericin B
Term
Systemic mycoses usually involve what organ system(s)?
Definition
GI and respiratory systems
Term
Does aflatoxin cause an allergic reaction?
Definition
No
Term
One of only a few fungi that has a toxin; this fungus' toxin intercalates into DNA
Definition
Aspergillus (toxin is aflatoxin)
Term
Can Aspergillus cause disease in all three ways that fungi can cause disease?
Definition
Yes
Term
Fungus associated with Farmer's lung
Definition
Aspergillus
Term
Etiological agent of aspergillosis
Definition
A. flavus
Term
Signs and symptoms of aspergillosis
Definition
* Rash
* Cough
* Respiratory distress
Term
Growth pattern of Aspergillus flavus
Definition
Filamentous (form hyphae)
Term
Is Aspergillus a primary or opportunistic pathogen?
Definition
Both
Term
What type of conidia do Aspergillus species have?
Definition
Microconidia
Term
Most common mold in US
Definition
Aspergillus
Term
Mass of fungus growing in the lung may be
Definition
Aspergilloma
Term
Describe an aspergilloma
Definition
* Fungus ball
* Non-invasive
* Encapsulated
* Hyphal mass
Term
Prognosis of aspergilloma
Definition
Systemic and invasive pulmonary asspergilosis are generally lethal
Term
Cause of aspergilloma
Definition
Inhalation of Aspergillus microconidia
Term
Diagnostic feature of blastomycosis
Definition
Broad-based bud under microscope
Term
Treatment of blastomycosis
Definition
Amphotericin B
Term
Growth mode of Blastomyces dermatitidis
Definition
Dimorphic with broad-based yeast
Term
How does Blastomyces dermatitidis enter the body?
Definition
Inhalation of fungal spores in dust
Term
Where is Blastomyces dermatitidis found in the environment?
Definition
Soil
Term
Most common fungal pathogen
Definition
Candida albicans
Term
Common complications of blastomycosis
Definition
Dissemination to skin and GU tract
Term
Disorder associated with painless lesions on face and upper body or purulent lesions on various organs
Definition
Blastomycosis
Term
Fungal disorder requiring treatment even in healthy individuals
Definition
Blastomycosis
Term
Most antifungals have been developed to treat what fungus?
Definition
Candida albicans
Term
Mucocutaneous signs of C. albicans
Definition
* Esophagitis, thrush
* Vulvovaginitis
Term
Fungal infection associated with curdlike discharge, burning, itches, and painful sexual intercourse
Definition
Candidiasis
Term
4th most prevalent bloodstream infection
Definition
Candidiasis
Term
Fungal infection associated with valley fever
Definition
Coccidioidomycosis
Term
Fungal infection responsible for coin lesion in lung
Definition
Coccidioidomycosis
Term
Cutaneous signs of candidiasis
Definition
* Onychia
* Diaper rash
Term
Thush and vulvovaginitis is suggestive of infection by what fungus?
Definition
C. albicans
Term
UTIs, endocarditis, and meningitis are complications associated with immunocompromised individuals with what infection?
Definition
Candidiasis
Term
Growth mode of Candida albicans
Definition
Polymorphic with bud-to-hyphal transition required for virulence
Term
Mortality of systemic candidiasis
Definition
35-40%
Term
Treatment of candidiasis
Definition
* Amphotericin B
* Fluconazoles
Term
Is C. albicans part of the normal microbiota?
Definition
Yes
Term
Second most common infection of AIDS patients
Definition
Cryptococcosis
Term
Fungus associated with bird, especially pigeon, droppings
Definition
Cryptococcus
Term
Budding yeast associated with pigeon droppings
Definition
Cryptococcus
Term
Fungal infection associated with valley fever in US and Mexico
Definition
Coccidioidomycosis
Term
Function of polysaccharide capsule of Cryptococcus
Definition
Anti-phagocytic (just like bacterial capsules)
Term
Fungal infection associated with meningitis
Definition
Coccidioidomycosis
Term
Conditions that coccidioidomycosis resembles
Definition
* Pneumonia
* Tuberculosis
Term
Two fungal organisms that evade immune system best
Definition
* Cryptococcus
* Histoplasma
Term
Growth pattern of Histoplasma
Definition
Dimorphic yeast
Term
Etiological agent of coccidioidomycosis
Definition
C. immitis
Term
Growth pattern of Coccidioides
Definition
Dimorphic; found as hyphae in soil
Term
Conidia associated with coccidioidomycosis
Definition
Arthroconidia
Term
Spherules are diagnostic of what type of fungal infection?
Definition
Coccidioidomycosis
Term
Treatment of coccidioidomycosis
Definition
Amphotericin B
Term
What fungal infection is most commonly associated with AIDS patients?
Definition
Pneumocystis pneumonia (PCP)
Term
Etiological agent of Pneumocystis pneumonia
Definition
P. jiroveci (previously P. carinii)
Term
What fungus associated with opportunistic infection in AIDS patients cannot be grown in culture?
Definition
P. jiroveci
Term
Treatment for Pneumocystis pneumonia
Definition
Trimethoprim and sulfamethoxazole
Term
What's unique about the treatment of P. jiroveci infections?
Definition
They target fungal metabolism, whereas most antifungals target the synthesis of structures unique to fungi
Term
Produces symptoms of bacterial meningitis
Definition
Cryptococcus
Term
Second most common infection after C. albicans, especially common in people exposed to bird droppings
Definition
Cryptococcosis
Term
Fungal infection producing primary lung lesions that are generally asymptomatic and self-limiting
Definition
Cryptococcosis
Term
Disseminated form of this fungal infection primarily reaches CNS and causes meningitis, but also reaches bone and skin
Definition
Cryptococcosis
Term
Growth pattern of Cryptococcus
Definition
Budding yeast
Term
This fungus grows as a budding yeast, has an antiphagocytic capsule, and can cause meningitis in AIDS patients
Definition
Cryptococcus
Term
Treatment of AIDS-associated cryptococcal meningitis
Definition
Amphotericin B and 5-flurocytosine for life
Term
What is the portal of entry of Cryptococcus fungi?
Definition
Inhalation of spores or dried yeast cells from bird droppings
Term
Fungal infection endemic to eastern US but also found in parts of Africa and Central/South America
Definition
Histoplasmosis
Term
This type of infection generally is asymptomatic, but some develop dry cough with blood-tinged sputum and skin lesions
Definition
Histoplasmosis
Term
Etiological agent of histoplamosis
Definition
H. capsulatum
Term
Growth pattern of H. capsulatum
Definition
Dimorphic yeast
Term
This fungus gains entry through inhalation of its conidia from bird or bat droppings
Definition
Histoplasma
Term
This fungus' conidia are engulfed by macrophages and grow intracellularly
Definition
Histplasma
Term
Treatment for histoplasmosis
Definition
Amphotericin B
Term
This fungal infection is associated with difficulty breathing, mild anemia, hypoxia, and fever
Definition
Pneumocystis pneumonia
Term
Portal of entry of Pneumocystis
Definition
Inhalation of droplets containing fungus
Term
Infection with this fungal species is diagnostic for AIDS
Definition
Pneumocystis jiroveci
Term
Treatment of PCP
Definition
Trimethoprim-sulfamethoxazole
Term
Medical name for ringworm
Definition
Tinea
Term
Mycoses are associated with what symptoms
Definition
* Itching
* Scaling skin patches
Term
Only type of fungus that can be transmitted from person-to-person
Definition
Dermatophytic (superficial) mycoses
Term
Etiological agents of dermatophytic mycoses
Definition
* Microsporum
* Trichophyton
* Epidermophyton
Term
Treatment of superficial mycoses
Definition
Topical antifungals (eg, nystatin, miconazole)
Term
Treatment of refractory lesions associated with dermatophytic mycosis
Definition
Oral griseofulvin and itraconazole
Term
Treatment for superficial mycoses of the hair and nails
Definition
Oral (systemic) therapy
Term
Fungal infection associated with farming, gardening, and peat moss
Definition
Sporothrix schenckii (an agent of subcutaneous mycosis)
Term
Fungal organism associated with lymphocutaneous sporotrichosis
Definition
Sporothrix schenckii
Term
Etiological agent of mycosis distributed in US midwest and Latin America
Definition
Sporothrix schenckii
Term
Inoculation with microconidia of S. schenckii is associatd with what type of lesions?
Definition
Slow-growing inflammatory nodules or ulcers
Term
Fungus associated with rose-handler's disease
Definition
Sporothrix schenckii
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