Term
| How do Ca+ channel blockers relax the uterus? |
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Definition
| By relaxing uterine smooth muscle by blocking the influx of Ca+ into and out of the myometrial cells. |
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Term
| What is inhibited by the lack of intracellular Ca+? |
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Definition
| the MLCK activity (myosin light chain kynase) |
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Term
| What is the most common CCB used? |
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Definition
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Term
| CCB is an approved for use in preterm labor....T or F? |
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Definition
| False...it has not been approved by the FDA so it is an off label use. |
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Term
| What are some common side effects of nifedipine? |
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Definition
| Headaches, hypotension, flushing, tachycardia, dizziness, nausea, edema, and palpitations. |
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Term
| What are some contraindications to CCB? |
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Definition
History of cardiac disease, vaginal bleeding, maternal hypertension, uterine infection.
Should not be given concurrently with MGSO4 or Beta-mimetics
Caution should be used in those with GDM & multiples |
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Term
| There are extensive maternal and fetal effects from nifedipine ...T or F? |
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Definition
| False- maternal effects are rare and there are no documented negative fetal effects. |
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Term
| What are some advantages of nifedipine? |
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Definition
More selective to uterine contractility
They are rapidly absorbed
Greater suppression of contractions, fewer side effects, and no known fetal effects when compared to other agents.
Oral administration |
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Term
| ACOG recommends nifedipine as a first line treatment for PTL....T or F? |
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Definition
| False-ACOG doesn't recommend any tocolytic as a first line because of conflicting reports. However, it supports the use of nifedipine as a first line. |
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Term
| What advantages does nifedipine have on neonates? |
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Definition
| Found to be associated with significant reductions in NEC, RDS, NICU admissions, intraventricular hemorrhage, and neonatal jaundice. |
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