Term
Nocice
nociceptionnonNociception – sensory process leading to perception of pain.– sensory process le˜Nociception – sensory process leading to perception of pain.ading to perception of pain. |
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sensory process leading to pain perception |
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Bare nerve endings in skin, muscle, joint, arteries and organs |
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thermal, mechanical and chemical stimuli |
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Amount of pain=amount of tissue injury |
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Pain modulated by balance of impulses
between A delta and C fibers |
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Brain produces patterns of
nerve impulses e.g. phantom
limb pain and neuropathies |
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pain inhibitory chemicals |
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endorphins, enkephlins, norepinephrin, GABA, serotonin |
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Pain excitatory chemicals |
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glutamate, aspartate, PGs, bradykinins, lymphokines |
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tissue injury and chronic inflammation releases |
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bradykinins, PGs (injury)
lymphokines(inflammation) |
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Acute pain manifestations.. |
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Anxiety, high heart rate, blood pressure, temperature,and blood sugar
dilated pupils
lower gastric acid sec., intestinal motility and blood flow |
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Superficial pain(connective tissue, muscle, bone, skin)
Sharp, dull, aching
Sensory fibers |
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Pain in internal organs & abdomen
Poorly localized
Ass. with nausea, vomiting, hypotension, restlessness
Carried by sympathetic fibers
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Pain in distant area(not original site)
Because of the same spinal segment as actual site
non-cardiac location of MI |
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Persistent/intermittent
lasts 3-6 months
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