Term
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Definition
| Form a bipolar mitotic spindle during cell division from tubulin |
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Term
| 2 groups of anticancer drugs |
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Definition
1) Depolymerization (Disassembly) of tubulin microtubules
2) Stabilization of tubulin polymers |
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Term
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Definition
periwinkle plant
2 Alkaloids:
1. Vinblastine
2. Vincristine |
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Term
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Definition
| Treats Pediatric leukemia and adult lymphomas |
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Term
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Definition
| Treats testicular carcinomas and Hodgkin's disease |
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Term
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Definition
| Never injected intrathecally because of its devastating neurotoxicity which is fatal |
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Term
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Definition
Estrogen linked to a nitrogen mustard via carbamate ester linkage
Broken down to estrone and estradiol
Used to treat prostate cancer |
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Term
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Definition
| Treats metastatic breast cancer |
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Term
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Definition
Taxane made from bark of Western yew
Works by allowing assembly to predominate over disassembly to provide stability of microtubules
Limited solubility in water so it is given in a vehicle of 50% ethanol and 50% polyethoxylated castor oil |
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Term
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Definition
Metastatic ovarian and breast cancers
Also used in drug-eluting coronary stents |
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Term
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Definition
Administered in polysorbate 80 to reduce hypersensitivity
Treats
1) Metastatic breast cancer
2) Non-small cell lung cancer |
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Term
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Definition
| Newest taxane for treatment of advanced prostate cancer |
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Term
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Definition
Promotes tubulin polymerization and microtubule stabilization
Indicated in combination with capecitabine for treatment of advanced breast cancer |
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