Term
| What percentage of people suffer from depression vs. bipolar disorder? |
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Definition
Depression: 6%
Bipolar: 1% |
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Term
| What percentage of depressed people respond to drugs? |
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Definition
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Term
| The first antidepressants increased levels of what neurotransmitters? |
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Definition
Monoamine NT
-DA
*NEpi
*5-HT |
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Term
|
Definition
| MAO regulates the amount of the NT, so an MAO-I inhibits those, which increases the amount of NT |
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Term
|
Definition
Effect of MAO-I
-Thyramine (found in cheese, wine, etc.) is broken down quickly by MAO in the liver
-elevates blood pressure |
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Term
| Tricyclic Antidepressants (TCAs) |
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Definition
| Increase levels of NEPI and 5-HT by blocking their reuptake transporters |
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Term
| What therapeutic index do TCAs have? |
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Definition
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Term
| Selective Serotonin Reuptake Inhibitors (SSRIs) |
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Definition
| Only blocks 5-HT reuptake |
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Term
|
Definition
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Term
| Selective NEpi Reuptake Inhibitors (SNRIs) |
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Definition
Only block NEpi reuptake
-as effective as SSRIs |
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Term
| In what two situations is Electroconvulsive Therapy (ECT) used? |
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Definition
1. If meds are not effective
2. When immediate treatment is needed (suicidal) until drugs take effect |
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Term
| How quickly does Selective REM deprivation work vs. Total sleep deprivation? |
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Definition
-REM: take as long as antidepressants
-Total: Immediate (but short lived) |
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Term
| Monoamine theory of depression |
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Definition
| There is an underactivity of monoamine transmitters (NEpi, 5-Ht, DA) |
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Term
| What 2brain abnormalities are related to depression? |
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Definition
-Increased activity in amygdala and orbitofrontal PFC
-Decreased activity in subgenual PFC |
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