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11/15 Disorders of the Anterior Ocular Segment
Neuro
79
Medical
Graduate
11/17/2011

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Term
dangerous anterior segment disorders
Definition
bacterial conjunctivitis
keratitis
uveitis
angle closure glaucoma
enhophthalmitis
orbital cellulitis
orbital tumor
Term
common anterior segment disorders
Definition
contact dermatitis
chronic blepharitis
stye
cataract
Term
ocular adnexa
Definition
eyelids and orbit

houses extra-ocular muscles and the course of the optic nerve
Term
disorders of adnexal tissues
Definition
common: contact dermatitis, chronic blepharitis, stye

dangerous: dacryocystitis, orbital cellulitis, orbital tumor
Term
contact dermatitis

presentation
Definition
hypersensitivity reaction to topical meds or cosmetics (characteristic distribution)

erthematous, leathery, scaly, thickening of skin
Term
contact dermatitis

treatment
Definition
discontinue offending agent

may need steroid cream (note: can increase eye pressure and cataract formation overtime)

refer to ophthalmologist if not resolved in 2 weeks
Term
chronic blepharitis

what is it?
Definition
inflammation of eyelids

anterior: staph a infection of skin, cilia, follicles

posterior: infection/inflammation of meibomian glands
Term
chronic blepharitis

clinical presentation
Definition
foreign body sensation, crusting upon awakening

redness, swelling, scaly, flaky debris on lid margins

mild conjunctival hyperemia
Term
chronic blepharitis
Definition
warm conpresses (5-10min 2x/day)

lid hygiene with baby shampoo

antibiotic ointment or oral antibiotics may be needed if it is severe
Term
stye

clinical presentation
Definition
a focal inflammation of ciliary follicles

painful, tender, focal mounding over days

mild conjunctival hyperemia

small abscess in sebaceous gland
Term
stye

treatment
Definition
warm compresses up to 4 times per day

chalazion (chronic granulomatous inflammation) may develop from scarring of a stye requiring excision
Term
dacryocystitis
Definition
*dangerous*

inflammation of the lacrimal sac (medial corner of the orbit/globe)

secondary to bacterial infection due to nasolacrimal passage obstruction
Term
dacryocystitis

presentation
Definition
tender, swelling in medial lower lid

discharge tearing

hyperemia of conjunctiva
Term
dacryosystitis

treatment
Definition
depends on severity - slightly different in kids vs. adults
definitely antibiotics at first
Term
dacryocystitis

treatment in children
Definition
oral amoxicillin/calvulanarte 10 days

IV cefuroxime if super sick

if not imroved in 24 hours - referral to ophthalmologist for imagaging and incisions of abscess
Term
dacryocystitis

treatment in adults
Definition
oral cephalexin for 10 days

IV cefazolin with severe systemic illness

incision and drainage of external abscess

imaging to rule out sinusitis, cancer of deformity
Term
orbital cellusitis
Definition
*dangerous*

diffuse bacterial infection of periocular tissue secondary to skin infection or paranasal sinusitis

periorbital edema

inflammatory spread throughout orbital fat surrounding the globe - can spread to brain, but treat urgently
Term
orbital cellusitis

clinical presenation
Definition
pain, fever

swelling, discoloration of lids

mild conjunctival hyperemia

reduced ocular motility (from fat involvement), proptosis (bulging globe), vision loss (with optic nerve involvement)
Term
orbital cellulitis
Definition
IV antibiotics

imaging

incision and drainage
Term
orbital tumor
Definition
*dangerous*

orbital extension
-paranasal sinuses
-distant metastasis
Term
orbital tumor

clinical presentation
Definition
pain

diplopia, proptosis (pushing on globe, not actually involving the globe)

tearing

conjunctival hyperemia

visual loss
Term
orbital tumor

treatment
Definition
imaging with CT and MRI

referral within 48 hours for further management
Term
dangerous disorders of the conjunctiva/scerla
Definition
conjunctivitis (only if bacterial)

sceritis

squamous carcinoma
Term
common disorders of the conjunctiva/sclera
Definition
viral conjunctivitis

episcleritis

pinguecula

pterygium

subconjunctival hemorrhage
Term
bacterial conjunctivitis
Definition
*dangerous*

more common in immunocompromised patients or exposed to hospital pathogens
Term
bacterial conjunctivitis

clinical presentation
Definition
ocular pain

diffuse hyperemia and swelling

purulent discharge - significant amount of copious discharge helps distinguish bacterial from viral conjunctivitis
Term
bacterial conjunctivitis

treatment
Definition
mild - observe 24 hours

topical erythromycin, aminoglycoside, trimethoprime, fluroquinolone

if from n. gonorrhoeae - IV ceftriaxone
Term
bacterial conjunctivitis patients that need to be referred to ophthamologist
Definition
with pus, all infants and compromised adult hosts

when n gonorrhoeae is suspected

any contact lens patient (bc might have corneal involvement)

after recent eye durgery
Term
ophthalmia neonatorum
Definition
bacterial conjunctivitis present at birth

silver-nitrate prohylaxis; infection of birth canal (chlamydia, gonorrhoeae, herpes simplex)
Term
viral conjunctivitis
Definition
most common cause of red eye

self-limited

most of adenovirus
Term
viral conjunctivitis

clinical presentation
Definition
diffuse hyeremia with follicles

watery discharge

ocular fullness (boggy/inflammed lids), warmth

tender, swollen, preauricular node

often UNIlateral

more acute onset
Term
viral conjunctivitis

treatment
Definition
does NOT need anti-microbial agents

topical lubrication (artificial tears)

cold compress

proper hygiene to avoid spread
Term
chylamdial conjunctivitis

clinical presentation
Definition
trachoma, neonatal, adult

hyperemia conjunctiva with follicles

mild mucoid discharge
Term
chylamidial conjunctivitis

treatment
Definition
send conjunctival scraping for culture

oral erythromycin, doxycycline or azithromycin

treat sexual partners or parents (to eliminate reinfection)
Term
allergic conjunctivitis
Definition
ITCHING

eyelid edema, watery discharge

conjunctival hyeremia

BIlatera, more CHRONIC course
Term
autoimmune conjunctivitis
Definition
systemic diseases can sometimes present in the eye first: Graves, RA, sjogren, lupus, Wegener, relapsing polychonritis

chronic, low grade conjunctival hyperemia

minimal discharge
Term
autoimmune conjunctivitis

treatment
Definition
treat underlying condition

refer within 2 weeks to rule out other causes

often requires systemic or local immunosuppression
Term
scleritis
Definition
*dangerous*

focal or diffuse inflammation of the sclera

associated with RA, Wegener, relapsing polychondritis
Term
scleritis

clinical presentation
Definition
severe pain

scleral thickening with dark purple color
Term
scleritis

treatment
Definition
evaluation for systemic involvement

systemic immunosuppression

EMERGENCY
Term
episcleritis
Definition
idiopathic focal inflammation of deep subconjunctival tissue

usually NOT associated with systemic disease
Term
episcleritis

clinical presentation
Definition
eye pain

focal or diffuse hyperemia
Term
episcleritis

treatment
Definition
refer to ophthalmologist with severe apin to make sure no other conditions

oral NSAIDs

topical lubrication
Term
pingueculum
Definition
degeneration of collagen in the nasal or temporal bulbar conjunctiva

secondary to wind and sun exposure (UV light)
Term
pingueculum

clinical presentation
Definition
mild ocular discomfort

focal hyperemia
Term
pingueculum

treatment
Definition
topical vasoconstrictors

(usually just observation)
Term
pterygium
Definition
fibrovascular proliferation of bulbar conjunctiva growing over cornea
Term
pterygium

clinical presentation
Definition
hyperemic growth over cornea

blurred vision
Term
pterygium

treatment
Definition
may require surgery if large
Term
subconjunctival hemorrhage
Definition
very common

due to sudden increase in intrathoracic pressure: sneezing, couching, strain, HTN, anticoagulation, blood dyscrasias
Term
subconjunctival hemorrhage

treatment
Definition
usually no treatment is necessary

will resolve on its own in 1-2 weeks
Term
corneal causes of red eye
Definition
abrasion (corneal abrasion, corneal foreign body)

non-traumatic keratopathy (dangerous!
-infection
-drying
-corneal endothelial dysfunction
Term
keratitis
Definition
inflammation of the cornea
-infection
-dry eyes
-contact lens over wear
-autoimmune disorders
Term
keratitis

clinical presentation
Definition
blurry vision

pain (cornea is highly innervated)

photophobia

foreign body sensation
Term
herpes simplex virus
Definition
primary HSV can cause:
trigeminal nerve infections
URI
unilateral folliular blepharoconjunctivitis
vesicular dermatitis
conjunctival ulcers
epithelial keratitis
Term
infections corneal ulcer

clinical presentation
Definition
pain, decreased vision, photophodia, epiphora

conjunctival injections

lid edema

*epithelial ulceration with suppurative stromal inflammation*

anterior chamber reaction
Term
gram + pathogens

clinical features
Definition
localized, cause less inflammation

round ulceration, grayish-white stromal infiltrate with distinct borders

minimal surrounding edema

stromal abscess

perforation
Term
gram (-) pathogens

clinical presentation
Definition
acute progression with intense inflammatory response

copious muculopurulent discharge

surrounding edema, stromal abscess, perforation

hypopyon: layering of WBCs

likely to affect vision more, even after resolution
Term
anterior chamber causes of red eye
Definition
ALL are dangerous conditions:

uveitis

angle closure glaucoma

infection (endophthalmitis)
Term
anterior uveitis
Definition
inflammation of the iris and ciliary muscle

usually autoimmune reaction
Term
anterior uveitis

clinical presentation
Definition
pain, photophobia, blurry vision, ciliary flush, irregular pupil

posterior synechiae and lens pigment - pigment from inflammatory cells on surface of the lens
Term
anterior uveitis

treatment
Definition
refer to ophthalmologist for work up

topical corticosteroids, cycloplegic
Term
acute angle closure
Definition
sudden elevation in intraocular pressure causing a blockage in outflow of aqueous humor
Term
acute angle closure

clinical features
Definition
acute periocular pain (severe)

nausea/vomiting

headache around eye

photophobia

blurry vision

ciliary flush
Term
acute angle closure

treatment
Definition
topical timolol & oral acetazolamid - aqueous reducing agents

refer to ophthalmologist urgently
Term
endophthalmitis
Definition
infection of the inside of the eye
-trauma
-surgery
-systemic infection
Term
endophthalmitis

clinical presentation
Definition
pain, vision loss, redness

hazy cornea, hypopyon

opacified cornea, diffuse edema, conjunctiva hyperemic
Term
endophthalmitis

treatment
Definition
refer to ophthalmologist immediately

intraocular fluid culture to diagnose bacterial process

intraocular and topical antibiotics
Term
ciliary flush
Definition
diffuse, radial dilation of blood vessels

+ foreign body sensation = corneal problem

+ lots of light sensitivity = inflammation IN eye (uveitis)
Term
the 7 dangerous red eyes
Definition
keratitis

bacterial conjunctivitis

uveitis

angle closure glaucoma

endophthalmitis

orbital cellulitis

orbital tumor
Term
cataract
Definition
any lens opacity

impairs vision by interfering with light transmission through the lens to retina

most common cause of visual loss in adults
Term
lens anatomy
Definition
consists of an outer capsule (basement membrane of lens epithelial cells), inner cortex, central nucleus

there are no vessels, lymphatics, nerves or connective tissue that go to the lens
Term
cataract classification
Definition
classification based on area that is opacified

cortical (outer layer, in cortex, peripheral)
nuclear
posterior
subcapsular
mature (very dense, cause significant loss of vision)
Term
cataract etiology
Definition
most commonly caused from aging

congenital is UNcommon but looked for in infancy bc surgery must be done right away

others: traumatic, med induced, metabolic disease, inflammation
Term
cataract progression
Definition
usually progresses asymmetrically

as nuclear cataracts progress - the may produce a myopic shift in the lens, increasing converging power and producing a temporary improvement in near vision
Term
diagnosing cataracts
Definition
history of painless, progressive visual decrease (often with glare symptoms)

evaluate red reflex and with ophthalmoscope
Term
cataract management
Definition
surgery (there are NO known diets, meds, supplements that can reverse or prevent cataracts)

indications for surgery:
-significant interference with visual tasks
-visualization of the retina/optic nerve
-treatment of lens related problems

*don;t recommend cataract surgery unless there is impairment
Term
restoration of vision after cataract surgery
Definition
vision may not be improved - especially if there was previous ocular damage

cornea - scarring, edema, inflammation
retina - macular degen, DB, retinal detach
optic nerve - atrophy, optic neuritis, glaucoma

if surgical complications
Term
complications of cataract surgery
Definition
bleeding, infection (endophthalmitis), "wound" problems, poor healing

corneal edema

retinal problems (macular edema, retina detachment)

persistent inflammation, glaucoma

opacification of capsular bag
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