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101811 Intro to Metabolism
UC MED 2015
29
Medical
Graduate
10/18/2011

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Cards

Term
Where is glycogen stored?
Definition
liver and muscle
Term
What are two main essential fatty acids?
Definition
linolenic and linoleic acids
Term
There is an unlimited storage capacity for which nutrient?
Definition
triglycerides (fats)
Term
Since there is no storage of free form amino acids, what happens to them (if there are in excess)?
Definition
Can be converted to glycogen or triglycerides and then stored
Term
Lipids produce more energy than both carbohydrates and proteins per gram, why is this?
Definition
Lipids are more reduced than both of them.
Term
Vitamins are essential in different reactions in the body, is their form altered?
Definition
No, they are cofactors.
Term
What vitamin is essential for amino acid metabolism?
Definition
B6
Term
What vitamin is an anti-oxidant?
Definition
Vit E
Term
What vitamin can also be classified as a hormone?
Definition
Vit D
Term
Wernicke-Korsakoff syndrome is caused by deficiencies in?
Definition
Thymine
Term
Bleeding disorders are caused by deficiencies in?
Definition
Vit K
Term
Megoblastic anemia is caused by deficiencies in?
Definition
B12 and folic acid
Term
What is the term for the energy used to keep all organs functioning while at rest?
Definition
Basal Metabolic rate
Term
How do you calculate BMR (basal metabolic rate)?
Definition
24 times weight in kg (units are kcal/day)
Term
How do you calculate daily energy need?
Definition
BMR + energy for work (1.3 times BMR for sedentary; 1.6 times BMR for moderately active; up to 2 times BMR for very active)
Term
If caloric intake exceeds the daily energy need then...
Definition
the person gains weight and it will mostly be stored in the form of triglycerides
Term
If caloric intake is below the daily energy need then...
Definition
the person will lose weight from use of triacylglycerol, and in severe starvation, proteins in the muscles
Term
To lose one lb of weight, you need to reduce how many calories?
Definition
3500 cal
Term
Easy question: the major energy source for biological reactions is?
Definition
ATP
Term
ATP contains (energy question)...
Definition
two high-energy bonds, which when hydrolyzed, give rise to ~7 kcal/mole of energy
Term
What is a high energy storage molecule that muscle uses in addition to ATP?
Definition
creatine-phosphate
Term
How do you calculate BMI?
Definition
weight(lbs)*703/height(in)^2
Term
Entry of sugars into metabolism
Definition
glycolysis
Term
Synthesis of glucose from metabolic precursors
Definition
gluconeogensis
Term
Why do we need enzyme regulation?
Definition
1) Prevent opposing pathways from being active at the same time (glycolysis vs gluconeogenesis). If this does not occur, futile cycles (now called substrate cycling) result.
2) Prevent biosynthetic pathways from operating when there is no need for the end product (ie, remember the lac operon)
3) Stimulate pathways to be activated when they are required (urea cycle for nitrogen disposal)
Term
What are some examples of the different types of enzyme regulation?
Definition
1) long-term adaptation- fatty acid biosynthesis and degradation
2) feedback inhibition- glycolysis
3) allosteric modification- any pathway; isozymes provide tissue specificity
4) covalent modification- glycolysis, glycogen metabolism, zymogen activation
5) compartmentation- fatty acid synthesis vs degradation
Term
What are metabolic problems that you can observe while in the blood contents?
Definition
1) lactic acidosis
2) ketoacidosis
3) hyperammonemia
4) hypercholesterolemia
Term
What enzymes in a blood test would indicate liver leakage (damage to the liver)?
Definition
AST, ALT
Term
What enzymes in a blood test would indicate pancreatic damage?
Definition
amylase
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