Shared Flashcard Set

Details

1005 Gene Regulation 1 Dr Cartwright
UC MED 2015 1005 Gene Regulation 1 Dr Cartwright
9
Medical
Graduate
10/09/2011

Additional Medical Flashcards

 


 

Cards

Term
function of beta-galactosidase
Definition
converts lactose to glucose and galactose to be utilized as nutrients
Term
operator
Definition
DNA sequence that binds the repressor protein
Term
Inducer
Definition
relieves the negative effect of repressor on transcription (is a de-repressor) by causing repressor to lose its affinity for the operator sequence
Term
components of lac operon
Definition
lacZ (galactosidase), lacY (permease), lacY (transacetylase). It is an inducible gene (in uninduced gene it is actively repressed)
Term
catabolite repression in lac operon
Definition
a feedback mechanism where little to no transcription occurs in presence of glucose whether lactose is present or not
Term
what are the two requirements for transcription at lac operon?
Definition
absence of repressor and presence of activator
Term
what happens to lac operon in presence of lactose and absence of glucose?
Definition
cAMP-CRP binds to a promoter proximal site and efficiently attracts RNA polymerase to the promoter, leading to relief of catabolite repression and promotion of active transcription
Term
relationship between levels of cyclic AMP (cAMP) and glucose
Definition
inverse relationship
Term
CRP
Definition
cAMP receptor protein
Supporting users have an ad free experience!