Term
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Definition
| Dogs, cats, and primates require what range of humidity? |
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Term
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Definition
| Rodent rooms require what range of humidity? |
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Term
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Definition
| Most animal rooms are maintained at what range of humidity? |
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Term
10-15 air changes
one every 4-6 minutes |
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Definition
| Proper ventilation for animal rooms must have how many air changes per hour? |
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Term
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Definition
| Similar to ICU cages, provides control of temperature, humidity, oxygen pressure etc. IV lines, catheter access ports, and monitoring devices can be incorporated. |
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Term
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Definition
| Used to provide exercise for animals, configuration depends on the species being housed. Primates may have jungle gyms or swings. Rodents may have exercise wheels. |
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Term
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Definition
| Primarily used to house dogs, sheep, goats, and farm animals. If outdoors must keep other animals from getting in outdoor enclosures, may cause a loss of dietary control, animal housed outdoors will need to become acclimated to seasonal changes. |
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Term
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Definition
| Cages with wheels may incorporate a squeeze section (primates) for temporary housing, does not need food or water sources. |
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Term
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Definition
| Used to collect urine and feces for measurement and analysis, food and water sources are locates outside of the cage to avoid addition to the waste. |
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Term
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Definition
| Solid bottomed, usually plastic typically have stainless steel grid top with a feeding station, usually have a filter top to control the micro environment are easily stacked or shelved. |
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Term
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Definition
| Strong, smooth, rust free, chemical resistant, high initial cost, may lower temperatures |
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Term
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Definition
| Lightweight, relatively low cost, less durable, may rust, can be damaged by chemicals. |
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Term
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Definition
| Lowest initial cost, they have a low to high impact strength, may be heat and chemical resistant, and may be transparent to allow for observation, may be used for disposable cages |
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Term
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Definition
Agents pose a high risk of causing life threatening disease. (Ebola)
Maximum containment procedures are exercised
Shower in/ shower out with full positive pressure body suits.
Personnel must undergo extensive training. |
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Term
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Definition
Agents can cause serious and potentially lethal disease.m (mycobacterium, tuberculosis)
Primary and secondary barriers are required to protect personnel
Access must be controlled. |
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Term
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Definition
Agents can cause disease in humans if handled incorrectly (toxoplasma, salmonella)
Limited access to the area
PPE must be used
Specific instruction for disposal of contaminated material. |
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Term
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Definition
Agents that do not normally cause disease in humans.
These agents may cause disease in immune compromised individuals
No specific handling or disposal requirements for this level. |
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Term
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Definition
| This refers to the individual cage, run, pen, where an animal is housed. |
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Term
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Definition
| This refers to the animal housing rooms. |
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Term
| The specific use for that room. |
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Definition
| The air pressure in a room is determined by what? |
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Term
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Definition
Means that the air flows from the hall into the room when the door is opened.
ex quarantine |
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Term
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Definition
Means the air flows from inside the room to the outside when the door is opened.
ex surgical suites
clean rooms |
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Term
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Definition
| Range of a temperature in which an animal does not not need physical or mechanisms to control heat production or heat loss. |
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Term
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Definition
Disposable clothing and all materials must be autoclaves, before being passed out of the facility through a special waste portal.
Air passing out of the facility must be treated with heat or filtration to remove infectious organisms.
Usually houses animals with infectious disease. |
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Term
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Definition
Similair to the layout of double corridor but requires of shower before entering the animal rooms.
Usually required to wear disposable clothing
Entry areas have an airlock
UV light is used to sterilize equipment and supplies.
Usually houses germ free animals. |
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Term
Intrinsic
Extrinsic
Dietary
Experimental |
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Definition
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Term
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Definition
Room doors open onto a central corridor
Common in smaller facilities
Cages cleaned in the room, bowls, and supplies cleaned in another to minimize cross-contamination. |
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Term
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Definition
| Quality and quantity of food and water |
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Term
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Definition
| Responsible for operations of facility including staff supervision and record maintenance. |
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Term
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Definition
| Usually has training in laboratory animal care specifically also a member of ASLAP, oversees all of the laboratory animal models. |
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Term
Labratory Animal Tecnologists
Labratory Animal Technicians |
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Definition
| Daily care, ensure all environmental variables are controlled, may also function as research technicians. |
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Term
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Definition
| Scientist often with an advanced degree, develops hypothesis and interprets data collected. |
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Term
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Definition
Animals should not be forced to work or produce for human benefit
Owning a pet is a form of enslavement.
Will break the law and make up information to try and shut down research facilities.
EX: PETA |
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Term
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Definition
We should treat animals as kindly as possible and that should be required by law.
The animal is suffering, we should relieve its suffering
Animal shelters mainly belong to this group |
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Term
Public Health Policy on humane Care and Use of Laboratory animals
PHS |
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Definition
| Agency within US Department of Health and Human Services, addresses the use of euthanasia to relieve pain and suffering in lab animals. |
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Term
Food and Drug Administration
FDA |
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Definition
| Ensures safety pf the public by enforcing adherence to the guidelines for research on certain products such as medication. |
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Term
Environmental Protection agency
EPA |
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Definition
| Administers laws to protect human health and the environment. |
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Term
Animal and Plant Health Inspection Service
APHIS |
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Definition
| Inspects research facilities for violations of AWA yearly. |
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Term
Regulatory Enforcement and Animal Care Program
REAC |
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Definition
| Enforces penalties for violators of AWA. |
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Term
United States Department of Agriculture
USDA |
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Definition
| Enforces the AWA, has APHIS and REAC as its main agencies. |
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Term
Institutional Animal Care and Use Committee
IACUC |
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Definition
| All animal use in research in the U.S must be approved by IACUC on independent entity that cannot be overruled, made up, of a group within the research facility and one community lay person. |
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Term
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Definition
| First passed in 1966. Governs the sale, transport, and use of animals. Required the formation of IACUC. Requires the PI to consult with the veterinarian to alleviate pain and suffering in animals used. |
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Term
American College of Laboratory Animal Medicine
ACLAM |
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Definition
| Provides standards of training for veterinarians in this field also performs the certification exam necessary for veterinarians. |
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Term
National Institute of Health.
NIH |
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Definition
| Provides grants and contracts to support research and training. |
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Term
Association for Assessment and Accreditation of Laboratory Animal Care
AAALAC |
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Definition
| Provides organization promoting humane treatment if animals in science, membership sought out because it signifies a commitment to excellence. does not make its own regulations. |
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Term
American Association of Laboratory Animal Science
AALAS |
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Definition
| Formed in 1950. Develops requirements for LAT's, LATG's, and ALAT's. |
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Term
| American Society of Laboratory Animal Practitioners. |
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Definition
| Group of veterinarians with special interest in lab animal medicine. |
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Term
consumer Product Safety Commission
CPSC |
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Definition
| Enforced regulations in the Federal Hazardous substance Act. |
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Term
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Definition
| This is the study of animals with completely known flora and fauna. |
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Term
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Definition
| Those animals with unknown microflora used for research. |
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Term
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Definition
| May be axenic, gnotobiotic, SPF, cesarean derived and barrier sustained animals. |
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Term
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Definition
Literally means "without strangers".
These animals are also refereed to as germ-free.
Usually have thinner walled intestines because they have not been exposed to any bacteria. |
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Term
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Definition
| These animals have specific microflora. Only the specified microorganisms are present. |
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Term
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Definition
Free of specific pathogens: may have other pathogens
Other then the identified pathogens, the microflora is undefined. |
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Term
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Definition
| These animals were derived surgically by removal of the mother's uterus and then the fetuses were removed in a sterile isolation chamber. |
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Term
| Barrier sustained or barrier reared |
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Definition
| These animals were delivered by cesarean section and then maintained in a sterile environment. Barrier may be a cage, room, or entire facility. |
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Term
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Definition
| Animals that are susceptible to a particular pathogen |
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Term
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Definition
| To use the fewest number of animals possible to achieve a result. |
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Term
Reduction
Refinement
Replacement |
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Definition
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Term
Basic research
Applied research
Clinical research |
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Definition
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Term
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Definition
| Concerned with advancing fundamental knowledge of life processes and diseases. |
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Term
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Definition
| Builds on the knowledge gained in basic and applied research. |
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Term
The institution for which the scientist works for
An independent agency
A government agency |
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Definition
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Term
| Animal exploitation groups |
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Definition
Generally believe that animals are for the use of human beings and are our absolute property.
Animals don't feel pain as we do
Usually advocates for bull fighting, dog fighting, etc. |
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