Term
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Definition
Family of viruses in the order nidovirales, includes:
Equine Viral Arteritis |
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Term
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Definition
+ve sense RNA
-icosahedral capsid
-envelope w. small peplomers |
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Term
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Definition
An orbivirus (family reoviridae)
-transmitted by vector biting midge
-results in hyperaemia of b.v. and so drooling, lameness, pul oedema w. resp. distress and cyanosis --> death |
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Term
| Bovine Viral Diarrhoea Virus (BVDV) |
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Definition
"1 virus, many diseases"
-immunosuppressive
-inf. w. non-pathogenic form often has no clinical signs
-occasionally mod-severe outbreaks (more pathogenic strain / cytopathic strain) - transient diarrhoea, fever, depressions, erosions of mouth, in some cases more severe (mucosal dz)
-in endemic herd see dec. fertility and sporadic cases of mucosal dz |
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Term
| Bovine Viral Diarrhoea Virus replication |
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Definition
-polycistronic single open reading frame
-does not usually cut off host cell synthesis
-exocytosis without cell lysis
-virus non-structural protein protease NSP2/3 blocks IFN production
(mutations in this result in cytopathic form of disease) |
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Term
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Definition
Family of viruses, includes:
-Feline Calicivirus
-Rabbit Haemorrhagic Disease |
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Term
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Definition
-3 open reading frames (ORFs)
-ORF1 - polpeptide -->protease, helicase, RNA polymerase
-ORF2 - capsid proteins
-ORF3 - protein which helps w. virus assembly |
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Term
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Definition
+ve sense RNA
-Small
-capsid = 90 dimers of single protein
-icosahedral symmetry
-non-enveloped |
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Term
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Definition
Family of viruses in the order nidovirales, includes:
-corona diarrhoea / enteritis in many spp
-Tranmissible Gasteroenteritis (TGE) in pigs
-Porcine epidemic diarrhoea
-Porcine Haemagllutinating Encephalomyelitis
-Feline Infectious Peritonitis |
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Term
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Definition
+ve sense RNA
-helically symmetrical capsid
-lipid envelope w. large peplomers |
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Term
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Definition
-an arteroviridae of horses
-sexually transmitted or via resp route.
-fever, rhitits, conjuntivits, leukopenia, urticatia, oedema, abortion |
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Term
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Definition
-cause of ~40% feline resp. inf.
-virus rep. mainly in URT
-salivation, lacrimation, sneezing, oedema and ulceration of m. memb. of mouth, fever, sicknes behv., depression, inappetance |
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Term
| Feline Infectious Peritonitis (FIP) |
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Definition
-condition of cats which occurs following infection w. a coronavirus which has a change in cell tropism and is able to replicate in macrophages
-peri-vascular necrosis, pyogranulomatous foci, peritonitis, pleurisy, uvetitis, CNS infection |
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Term
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Definition
Family of viruses including:
-Flavivirus
-Pestivirus |
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Term
| Flaviviridae (flavivirus and pestivirus) structure |
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Definition
+ve RNA
-small
-spherical capsid
-icosahedral symmetry
-tight lipid envelope w. peplomers |
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Term
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Definition
e.g. Louping ill
All viruses are arbovirus |
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Term
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Definition
-polycistronic single open reading frame
-does not usually cut off host cell synthesis
-exocytosis without cell lysis |
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Term
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Definition
-caused by Flavivirus
-tick-borne
-primary vireamia, if prolonged get secondary vireamia:
-non-suppurative encephalomyelitis, resulting in CNS signs, progress to coma and death |
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Term
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Definition
An order of viruses.
Includes the families:
-Coronavirus
-Arteroviridae
(replication of both involves nested transcriptions) |
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Term
| Nidovirales (coronaviridae and arteroviridae) replication |
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Definition
Nested transcripts
-each w. a poly-A tail, varying length middle, leader sequence
-protein nearest 5'end leader is translated - economical |
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Term
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Definition
Includes Bluetongue
African Horse Sickness |
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Term
| Porcine Epidemic Diarrhoea |
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Definition
| -Coronavirus enteritis / diarrhoea of pigs, v. similar to TGE but less severe |
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Term
| Porcine Haemagglutinating Encephalomyelitis |
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Definition
| -Coronavirus of pigs = Vomiting and Wasting dz i.e. not enteritis / diarrhoea |
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Term
| Rabbit Haemorrhagic Disease (RHD) |
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Definition
-a calicivirus
-high morbidity and mortality (~100%) in rabbits >2mnths
-primary target cell = MN
-lesions in multiple organs with numerous haemorrhage --> DIC --> death |
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Term
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Definition
Family of viruses, includes:
-Rotavirus
-Orbivirus |
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Term
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Definition
ds RNA
-"russian doll structure" - core particle w. genome and RNA polymerase, inner capsid, outer capsid
-non-enveloped |
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Term
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Definition
A virus of the reoviridae family
-commonest cause of enteritis and diarrhoea in neonates
-virus releases a toxin - inhibits symporter of glucose and Na and causes release of Ca++ from ER into cytoplasm |
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Term
| Rotavirus (orbivirus similar) replication |
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Definition
-capsid has 3 layers
-genome remains in core particle, which has RNA polymerase and capping enzymes - dsRNA is potent IFN inducer and is kept hidden from host |
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Term
| Transmissible Gasteroenteritis |
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Definition
-Coronavirus enteritis / diarrhoea of pigs, virus infects villi enterocytes
-yellow, fluid diarrhoea and dehydration |
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