Term
| What are barbiturates derived from? |
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Definition
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Term
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Definition
| By progressive depression of the central nervous system |
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Term
| How do barbiturates work? What do they get absorbed in? |
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Definition
| They get absorbed into the brain, which produces unconsciousness |
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Term
| When does recovery occur? |
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Definition
| When the brain levels fall too low to affect the brain |
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Term
| Where is it metabolized? Excreted? |
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Definition
| Metabolized by liver and excreted by kidney |
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Term
| What are the reversal agents for barbiturates? |
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Definition
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Term
| Are barbiturates known for their analgesic properties? Are they controlled? |
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Definition
| No, and yes...the human race has made it possible to get addicted-genius! |
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Term
| How do we administer barbiturates? |
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Definition
| Powder form that needs to be reconstituted. IV, give to effect. |
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Term
| who do we need to monitor closely during the use of barbiturates? |
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Definition
| Patients with respiratory depression and apnea |
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Term
| Barbiturates depress what? |
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Definition
| Cardiovascular system and respiratory system |
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Term
| Why should hypoproteinemic patients receive a lower dose of a barbiturate? |
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Definition
| Because they're normally partially protein-bound...so if the animal don't got lots of proteins, den dey could be kilt frum ovadoze |
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Term
| It has various interactions with other drugs, what do we do? |
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Definition
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Term
| To avoid or correct going too deep, what can we do? |
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Definition
| Bag regularly, or use lower dose. (oh, or just avoid it all together) |
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Term
| Is it safe for sighthounds, or lean patients? |
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Definition
| Yes, it's safe, it just causes them to sleep for days |
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Term
| Why do the skinny minnies of dog world sleep forever and a day when given barbiturates? |
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Definition
| Because they don't have much fat for the barbiturate molecules to redistribute to-so it'll stay in their blood and brain...deepening and prolonging anesthesia |
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Term
| If injected perivascularly, what happens? |
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Definition
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Term
| Why is it bad if you accidentally give it perivascular, or under-dose a patient with barbiturates? |
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Definition
| The patient gets put into excitement stage, and at that point it's hard to get them deeper. It will be harder to anesthetize, and it'll most likely take more drugs |
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Term
| Prolonged recovery can be caused by what? |
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Definition
| #liverprobz #kidneyprobz #hypothermia (because the liver enzymes are not as active) |
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Term
| Soooo...who should we basically avoid when giving barbiturates? |
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Definition
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Term
| What are the most commonly used barbiturates in vet med? |
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Definition
| Thiopental - Pentothal (CIII) |
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Term
| Not so commonly used barbiturates? |
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Definition
Generic Trade
Pentobarbital - Nembutal
Thiamylal - Biotal, Surital
Methohexital - Brevital |
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Term
| Which one is not commonly used but is the only one still available? |
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Definition
Generic Trade
Pentobarbital-Nembutal |
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