Term
| Propofol was developed when? |
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Definition
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Term
| Propofol was used for animals since 1986, where? In the UK or US? |
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Definition
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Term
| The USA finally had propofol approved in dogs when? |
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Definition
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Term
| Trade names for propofol... |
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Definition
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| T/F...Propofol falls under the category of barbiturates. |
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Definition
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Term
| T/F...Propofol falls under the category of dissociatives. |
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Definition
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Term
| Is propofol related to any other anesthetic drugs? |
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Definition
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Term
| Describe propofol's apperance |
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Definition
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Term
What is propofol?
An oil in water ______? |
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Definition
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Term
| Because it can grow bacteria, should we keep it out in the open, where light can penetrate it all day, err day? |
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Definition
| hail nah, mayne. it's a nutrient broth, so don't refridgerate that ish either! |
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Term
| With the new and improved propofol, what do we refer to it as? |
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Definition
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Term
| What does propofol 28 contain? |
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Definition
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Term
| How many *days* can we use it for after opening? |
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Definition
| 28, huh...it's in the name..nothing in vet is ever that easy |
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Term
| What do we use propofol for? (2) |
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Definition
-sole agent for short procedures, 20 minutes at most
-anesthetic induction for intubation |
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Term
| Are premeds required with propofol? |
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Definition
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Term
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Definition
| Any tranquilizers, it will just reduce the dose of propofol needed |
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Term
| How do we administer this drug? |
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Definition
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Term
| How long do we give propofol via IV? |
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Definition
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Term
| What does "give to effect" mean? |
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Definition
| Until patient is deep enough, give them only what they need |
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Term
What is the onset time?
What is the duration time?
What is the recovery time? |
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Definition
Onset: Within 60 seconds
Duration: 6-20 minutes
Recovery: Fairly rapid |
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Term
| What happens when we give it too rapidly? :( |
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Definition
| Apnea..in the words of Dr. Malcolm... "it will" |
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Term
| What happens when we give it too slow? |
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Definition
| Wont get deep enough, because patient's already started metabolizing it |
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Term
| What might we see during induction? |
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Definition
| transient excitement and muscle tremors, but they're mild. |
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Term
| Does propofol mix well? If so, what's our go to mixer? |
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Definition
| It doesn't mix well, duuur. |
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Term
| One reason why vets LOVE propofol, what is it? |
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Definition
| Not suppose to have an excitement stage (it's very mild if it does) |
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Term
| Can we repeat injections of propofol? If so, how many times, and/or how far apart from each other? |
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Definition
| Yes, every 3-5 minutes is fine. |
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Term
| What's the advantage of the fact that we can repeat injections of propofol? |
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Definition
| It does NOT prolong the recovery |
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Term
| The patient should be in full standing recovery how long after the last injection of propofol? |
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Definition
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Term
| Why is recovery so quick? |
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Definition
| Rapid distribution and metabolism in the liver and lungs |
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Term
| Where does metabolism take place during recovery? |
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Definition
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Term
| Where are those metabolites excreted during recovery? |
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Definition
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Term
| Unfortunately, what could delay recovery? |
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Definition
| If you used acepromazine as a premed |
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Term
| Is propofol okay to use in dogs and cats? |
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Definition
| YES! It has a wide margin of safety! |
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Term
| Is propofol okay to use in patients with renal and hepatic disease? |
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Definition
| You bet (what Dr. VL would say) |
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Term
| Ruh roh, is propofol controlled? What class? |
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Definition
| It's NOT controlled, but because of MJ...it's a comin'! |
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Term
| Is propofol safe for sighthounds? What can occur with them during recovery? |
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Definition
| YES, but may have delayed recovery :( |
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Term
| T/F...Propofol is a great analgesic |
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Definition
| False, it has very poor analgesia |
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Term
| Why would we need to avoid propofol in septicemic patients? |
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Definition
| It may make infections worse |
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Term
| How long is the shelf life for an unopened vial 'o propofol? |
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Definition
| About 3 years! (that's good) |
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Term
| How long is the shelf life for an opened vial 'o propofol? |
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Definition
| 24-48 hours (if refrigerated)! |
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Term
| According to the package instructions, how long is the shelf life? |
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Definition
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Term
| Are there any antimicrobial preservatives? |
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Definition
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Term
| What should you always do when sticking a needle in the vial? |
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Definition
| Use strict aseptic technique but wiping off the top before sticking the needle through |
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Term
| Can overdose occur in propofol? How? |
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Definition
| Yes, if administration was too rapid, or just accidental |
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Term
| When the patients overdosed, what occurs? (no, not death) |
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Definition
| Cardiopulmonary depression, that includes apnea. |
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Term
| What do we do when the patient is struggling to breathe because of an overdose? |
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Definition
| Intubate and assist ventilation as needed. USE PURE 0XYGEN. |
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Term
| Side effects of propofol? (there are a lot...) |
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Definition
| Apnea, tachypnea, dyspnea, hypotension, bradycardia, tachycardia, cyanosis, arrhythmias, muscle tremors, paddling, seizures, CNS excitation, CNS depression, vomiting, salivation. |
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Term
| Do all the side effects of propofol happen? At once? |
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Definition
| No, they're basically just what has been reported and seen before. It could have happened once, and never again. They're not common, nor are they severe. |
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Term
| What precautions must we take with propofol? Who do we not evaluate for use in? |
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Definition
| Preggos, or breeding dogs, pups under 10 weeks, and dogs in renal or hepatic failure. |
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Term
| Why can't we give it to patients in renal or hepatic failure? I thought propofol had a "wide margin of safety"? |
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Definition
| It needs to be metabolized by the liver...so if it aint werkin', dat shit aint gone fly-cause it aint gone just sit there and just hope it gone be metabolized by sumthin' else. DAMN. Wuts gud? |
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Term
| who do we use in CAUTION with? |
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Definition
-sick or debilitated dogs
-geriatric, hypovolemic
-cardiac, respiratory, renal or hepatic disease |
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Term
| What agents do we use in the "Post-Anesthetic" period? |
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Definition
| Doxapram, yohimbine, atipamezole, flumazenil, and narcotic antagonists |
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Term
| How do we usually administer doxapram? What's the trade name for doxapram? |
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Definition
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Term
| What is doxapram? Does it have a wide margin of safety like propofol? |
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Definition
| It's an analeptic agent, it's a drug that causes general CNS stimulation |
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Term
| Doxapram is a _____ stimulant. |
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Definition
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Term
| Does doxapram increase or decrease the RR and depth? |
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Definition
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Term
| We take caution in cardiac diseased patients, why? |
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Definition
| It may cause tachycardia, arrhythmias |
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Term
| What is doxapram good for with neonates? How do we administer it? |
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Definition
| Good for stimulating respiration, place drop under tongue |
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Term
| What do we use to reverse xylazine? |
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Definition
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Term
| What do we use to reverse medetomidine? |
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Definition
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Term
| What do we use to reverse diazepam? |
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Definition
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Term
| What do we use to reverse Opioids like oxymorphone? |
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Definition
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