Shared Flashcard Set

Details

Vaccination and Vaccines
Immunization/ Vaccines
53
Veterinary Medicine
Not Applicable
12/03/2013

Additional Veterinary Medicine Flashcards

 


 

Cards

Term
12 th century
Definition
Chinese developed variolation ( introducting antigen to wound)
Term
What was the first vaccine ?
Definition
Cowpox
Term
1754 inoculation against what?
Definition

Rinderpest 

( 1st veterinary Vx) 

Term
In 1976 who im poroved variolation?
Definition
Edward Jenner
Term
1879 what did Louis Pasteur do?
Definition
Attenuated organism (birds)
Term
What type of Vx is salmonella and who made it?
Definition
Killed organism and Salmon
Term
Who used no oragnisms Vx essentially used antibodies?
Definition
von Behring and Kitasato
Term
What is meant by passive immunity?
Definition
Transfer of antibodies
Term
Mechanism of passive immunity?
Definition

Immediate 

Temporary

Term
What is active immuntiy?
Definition
when an antigen stimulates immune response
Term
What are the mechanisms / propertiesof active immunity?
Definition

Protection is not conferred immediatly (body has to build it)

 

Long lasting 

 

Capable of restimulation

 

artifical 

Term

Types of biologicals 

 

Antiserum 

Definition
Serum that contains specific antibodies
Term
What immune response does antiserum belong to
Definition
Passive
Term

Types of biologicals 

 

Antitoxin 

Definition
Antiserum directed against a toxin
Term
Which immunse response does Antitoxin belong to?
Definition
Passive
Term

Types of biologicals 

 

Toxoid 

Definition

Non toxic  derivatives of toxins used as antigens

( doesnt last long so levels won't be as high) 

Term
Which immune resonse does toxoid belong to ?
Definition
Active
Term

Types of biologicals 

 

Bacterin 

Definition
A preparation of a killed bacteria used for immunization
Term
Which immune response does bacterin belong to ?
Definition
Active
Term
What is an attenuated vaccine?
Definition
The reduction of a virulence of an infectious agent
Term
Attenuuation results in?
Definition
Weakening abilty to cause Dz
Term
What is an inactivated vaccine?
Definition

Treatment of an ingfectious agent so that it can no longer replicate 

 

 

Term
What is an adjuvant vaccine?
Definition

Any substance that when given with / added to an antigen enhances the immune response to that antigen 

( greater response)

Term

Living Vs. Killed 

 

Few inoculating doses required 

Definition
Living
Term

Living Vs. Killed 

 

Adjuvants unnecessary 

Definition
Living
Term

Living Vs. Killed 

 

Less chance of hypersensativity 

 

Definition
Living
Term

Living Vs. Killed 

 

Relativley inexpensive 

Definition
Living
Term

Living Vs. Killed 

 

Induction of interferon 

Definition
Living
Term

Living Vs. Killed 

 

Residual virulence 

(maintains ability to go viral)

Definition
Living
Term

Living Vs. Killed 

 

Stable on storage 

Definition
Killed
Term

Living Vs. Killed 

 

Unlikey to cause Dz

Definition
Killed
Term

Living Vs. Killed 

 

Unlikey to contain contaminating organisms 

Definition
Killed
Term
How many categories are included in the USDA classification of genetically enegineered biologicals?
Definition
I, II, II
Term
Category I
Definition
Vaccines that contain purified antigens derived from recombient organisms
Term
What are the 2 vaccines that contain purified organisms from recombient organisms?
Definition

FeLV 

(gp70)

 

Lyme 

(Osp A)

Term
Catergory II
Definition
Vaccines containing live organisms that contain gene deletions
Term
One example of a Class II vaccine
Definition
Pseudorabies
Term
What is an igredient in Pseudo rabies?
Definition

Thymidine Kinase 

( necessary for reproduction of organism) 

Term
Catergory III
Definition
Contain live expression vectors containing heterologous genes for immunizing antigens
Term
Example of a catergory III vaccine
Definition
Oral rabies bait
Term
What is an oral rabies bait
Definition

G glycoprotein 

vaccinia

Term
Rule of vaccine assessing
Definition
Must be sure that the risks of vaccination o not exceed those associated witht he chance of contracting the disease itself
Term

% of controls dieing - % of vaccinates dieing 

Over % of controls dieing 

Definition
Preventable factor
Term
What probability does herd immunity reduce?
Definition

Susceptible animal meeting an infected on 

Disease is slowed or terminated 

Term
Immunity conferred on a population as a result of the presence of immune individuals within that population
Definition
Herd immunity * livestock
Term

T/ F

When administering vaccine doses should always be split never using full doses. 

Definition
False
Term

T / F 

Vaccines don't have a designated shelf life?

Definition
False
Term

T / F 

Vaccines that have to be reconsitiuted can be done with any of the vaccine reconstitution agents?

Definition
False
Term
Different ways Vx can be manufactured
Definition

Modified live 

Inactivated 

Purified subunits 

Recombiant 

Dna (usually reseach) 

Term
Licensing of Veterinary Vx
Definition

USDA---> 

Animal Plant Health Inspection Service ----> 

Veterinary Services (dept within) ----> 

*Center for Veterinary Biologics *

Term

Adverse consequence of Vx 

"normal" toxicity 

Definition

Fever

Malaise 

Inflammation 

Pain 

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