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| Urinary system structures: |
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2 kidneys 2 ureters urinary bladder urethra |
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| Urinary system functions: |
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Regulates blood pressure electrolyte content of blood pH balance of blood tissue fluid eliminates urine |
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retroperitoneal (behind peritoneum) below diaphragm within rib cage cushioned by adipose tissue Covered by renal fascia (fibr. conn. Tissue) hilus – indention on medial side |
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| INTERNAL KIDNEY STRUCTURE 3 areas: |
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Renal cortex Renal medulla Renal pelvis |
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| Outer tissue layer made of renal corpuscles & convoluted tubules (parts of nephrons) |
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| Inner tissue layer made of loops of Henle & collecting tubules (parts of nephron) |
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| Cavity formed by expansion of ureter within kidney at hilus |
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| Funnel-shaped extensions called |
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| Calyces enclose papillae of renal pyramids |
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| Renal pyramids into calyces, to renal pelvis & into ureter |
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| Structural & functional unit of kidney |
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| Nephrons form urine in association w/ |
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| Glomerulus within Bowman’s capsule |
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| Bowman’s capsule is expanded end of |
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| Renal tubule that encloses glomerulus; inner layer (podocytes) creates spaces/pores (permeable); outer layer has no pores; space between contains renal filtrate |
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| Renal tubule continues from |
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| Bowman’s capsule surrounded by peritubular capillaries |
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1) proximal convoluted tubule loop of Henle distal convoluted tubules collecting tubules |
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| Proximal convoluted tubule is |
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| Collecting tubules unite to form a |
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| Papillary duct that empties into calyx of renal pelvis |
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Renal artery Capillaries/Glomeruli Renal vein |
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receives blood from abdominal aorta branches extensively w/in kidney into smaller branches |
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receives blood from glomeruli takes blood to the inferior vena cava |
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| Abdominal aorta – renal artery – smaller arteries in kidney – afferent arterioles in renal cortex – glomeruli – efferent arterioles – peritubular capillaries – veins in kidney – renal vein – inf. Vena cava |
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| FORMATION OF URINE - 3 major processes: |
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Definition
1. Glomerular Filtration Tubular Reabsorption Tubular Secretion |
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• Blood pressure forces plasma, dissolved substances & small proteins out of glomeruli & into Bowman’s capsule (renal filtrate) Blood cells & larger proteins remain in blood GFR (glomerular filtration rate) – amount of renal filtrate formed in 1 min. |
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• Takes place from renal tubules into peritubular capillaries ~ 99% filtrate reabsorbed back into blood; only 1% enters renal pelvis as urine Most reabsorption occurs in proximal convoluted tubules whose cells have microvilli (> surface area) Distal convolutes tubules & collecting tubules reabsorb h2o |
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| Mechanisms of Reabsorption: |
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• Active transport – cells use ATP to move useful materials to blood (glucose, amino acids, vitamins & + ions) Passive transport – many – ions Osmosis – follows absorption of minerals, esp. Na+ ions Pinocytosis – small proteins absorbed by cell membrane |
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• Changes composition of urine Substances are actively secreted from blood into peritubular capillaries into filtrate in renal tubules Waste products & metabolic products of meds. H+ ions may be secreted by tubule cells to maintain normal blood ph |
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| Hormones influencing water reabsorption: |
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1. Aldosterone Atrial natriuretic peptide (ANP) Antidiuretic hormone (ADH) |
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| Atrial natriuretic peptide (ANP) – decreases |
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| Antidiuretic hormone (ADH) |
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| Distal convoluted tubules & collecting tubules able to reabsorb water from filtrate |
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1. Secretion of renin Secretion of erythropoietin Activation of vitamin D |
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• Secreted by walls of afferent arterioles when BP decreases Initiates renin-angiotensin mechanism to raise BP End product, angiotensin II, causes vasoconstriction & increase secretion of aldosterone |
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| Secretion of erythropoietin |
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• Hormone secreted when blood O2 level decreases Stimulates red bone marrow to increase rate of RBC production |
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| Converted to calcitrol (D2) which increases absorption of calcium & phosphate |
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• Ureters Urinary bladder Urethra The Urination reflex |
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• Smooth muscle Each extends from hilus of kidney to lower, backside of urinary bladder Smooth muscle of walls propel urine toward bladder in peristaltic waves Lower ends compressed as bladder fills, preventing backflow |
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• Mucosa Trigone Detrusor muscle Muscular sac Reservoir for urine Contracts to eliminate urine |
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| Urethra carries urine from bladder to exterior |
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| Smooth muscle layer of wall that forms a sphere; when contracts becomes smaller & volume diminishes; muscle fibers around urethral opening form internal urethral sphincter (involuntary) |
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| External urethral sphincter |
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• Skeletal muscle on pelvic floor under voluntary control |
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• Urination is aka: micturition or voiding Stimulus is stretching of detrusor muscle Can be prevented by voluntary contraction of external urethral sphincter (until too full) Spinal cord reflex where voluntary control may be exerted |
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| Mucosa (transitional epithelium) allows |
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| Points of triangle are openings of ureters & urethra |
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Amount Color Specific gravity pH Constituents Nitrogenous wastes |
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| Normal kidney urine output |
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| Excess sweating or diarrhea, causing body to conserve water |
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| Excessive fluid intake, alcohol; increased urine formation & output |
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• “Straw” or “amber” due to breakdown of bile Concentrated urine is deeper yellow than dilute urine. Freshly voided urine is clear. |
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| Measure of dissolved materials in urine; indicator of kidney’s concentrating ability |
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| Normally between 4.6 & 8.0 (avg. 6.0); greatly influenced by diet |
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| Salts are not considered true waste products but excess amts. Are eliminated in urine. |
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| Urea (liver cells), creatinine (creatine phosphate metab.), uric acid (metab. Nucleic acids), and sm. Amts. Urobilin (from Hgb of old rbcs) |
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| Kidney related abnormalities |
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Floating kidney Renal failure Anemia Kidney stones UTI |
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| One that has moved out of Nl. Position; ureter may become twisted or kinked |
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| Inability of kidneys to Fx properly; prerenal (in blood flow to kidneys), intrinsic (prob. W/kidneys) or postrenal (somewhere else in urinary tract) |
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| Artificial kidney machine filters blood |
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Consequence of renal failure; hemodialysis can’t reverse Stoppage of erythropoietin production |
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Aka renal calculi Concentrations of crystals of salts (calcium or uric acid) that most likely form in renal pelvis & cause intense pain & bleeding May cause backup of urine & possible kidney damage |
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| Inflammation of urinary bladder |
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| UTI Bacteria usually from |
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a) Which structure carries urine from bladder out of body? hilus nephron trigone ureter urethra |
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a) Outer tissue layer of kidney is called renal _____. capsule cortex medulla pelvis pyramid |
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a) The _____ is the capillary network of the nephron. Bowman’s capsule glomerulus renal medulla renal pelvis renal pyramid |
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a) Which structure carries urine from kidney to bladder? hilus nephron trigone ureter urethra |
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a) Inner tissue layer of kidney, containing loops of Henle and collecting tubules, called renal _____. capsule cortex medulla pelvis pyramid |
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a) The _____ encloses the capillary network of the nephron. Bowman’s capsule glomerulus renal medulla renal pelvis renal pyramid |
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a) The cavity formed by expansion of ureter within kidney, at hilus, is called renal _____. capsule cortex medulla pelvis pyramid |
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a) Which process involves blood pressure forcing plasma out of glomeruli into Bowman’s capsule within nephron? glomerular filtration tubular reabsorption tubular secretion |
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a) Which secretion of the kidneys influences blood pressure? bilirubin calcitrol erythropoietin renin urea |
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a) Which process involves incorporation of most of the filtrate back into the blood? glomerular filtration tubular reabsorption tubular secretion |
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a) Which secretion influences red blood cell production? bilirubin calcitrol erythropoietin renin urea |
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a) Which process changes the composition of urine, releasing waste products into the filtrate? glomerular filtration tubular reabsorption tubular secretion |
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a) Which characteristic of urine measures dissolved materials in urine and indicates kidney’s concentrating abilities? amount color constituents nitrogenous wastes specific gravity |
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a) Which of the following medical terms means “little production of urine?” anuria dysuria minuria oliguria polyuria |
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