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Tortora Chapter 4
Tissue Level of Organization
133
Anatomy
Undergraduate 1
02/06/2011

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Term
lateral surfaces
Definition
the sides of an epithelial cell that face adjacent cells on each side
Term
caherins
Definition
transverse proteins that join the cells
Term
basal lamina
Definition
the layer of the basement membrane that is closer to and secreted by the epithelial cells
Term
stratified epithelium
Definition
consists of two or more layers of cells that protect underlying tissues
Term
connexins
Definition
membrane proteins which form fluid-filled tunnels.
Term
connective tissue
Definition
protects and supports the body and its organs; binds organs together, and stores energy reserves as fat; helps provide immunity to disease-causing organisms
Term
ectoderm
Definition
the primary germ layer that gives rise to the nervous systems and the epidermis of the skin and its derivatives.
Term
integrins
Definition
transmembrane glycoproteins used by cells to attach to intermediate filaments inside the cell and the basement membrane outside the cell
Term
muscular tissue
Definition
generates the physical force needed to make body structures move and generates heat
Term
desmosomes
Definition
contain plaque and have transmembrane glycoproteins called cadherins that extend into the intercellular space between adjacent cell membranes attaching cells to one another; the plaque does not attach to microfilaments but rather to intermediate filaments of the protein keratin; prevent epidermal cells from pulling apart under tension & cardiac muscle cells from pulling apart during contraction
Term
simple epithelium
Definition
a single layer of cells that functions in diffusion, osmosis, filtration, secretion, or absorption.
Term
secretion
Definition
the production and release of substances such as mucus, sweat, or enzymes.
Term
hemidesmosomes
Definition
are like half of a desmosome; they have transmembrane glycoproteins called integrins which attach cells to the protein laminin in basement membranes
Term
basement membrane
Definition
a thin , extracellular layer that consists of 2 layers: the basal lamina and reticular lamina
Term
glandular epithelium
Definition
makes up the secreting portion of many glands
Term
mesoderm
Definition
the middle primary germ layer that gives rise to the connective tissues, blood and blood vessels and muscle
Term
covering & lining epithelium
Definition
one of the two types of epithelial tissues; forms the outer covering of the skin and some internal organs & the inner lining of the blood vessels, duct, body cavities; lines the interior of the respiratory, digestive, urinary and reproductive systems
Term
primary germ layers
Definition
the first tissue formed in the human embryo from which all other tissues of the body develop
Term
basal surface
Definition
the side opposite the apical surface; this surface often adheres to extracellular materials such as the basement membrane
Term
pseudostratified epithelium
Definition
appears to have multiple layers of cells because the cell nuclei lie at different levels and some of the cells do NOT reach the apical surface
Term
adherens junctions
Definition
contain plaque, a dense layer of proteins on the inside of the plasma membranes, that attaches both to membrane proteins and to microfilaments of the cytoskeleton
Term
reticular lamina
Definition
the layer of the basement membrane that is closer to the underlying connective tissue and secreted by the connective tissue cells
Term
cell junctions
Definition
contact points between the plasma membranes of the tissue cells
Term
epithelial tissue
Definition
covers body surfaces, lines hollow organs, body cavities and forms glands; has 3 major functions: barriers that limit or aid the transfer of substances into & out of the body; secretory surfaces that release products produced by the cells onto their free surfaces; protective surfaces that resist the abrasive influences of the environment
Term
apical (free) surfaces
Definition
the side of an epithelial cell that faces the body surface, a body cavity, the lumen (interior space) of an internal organ, or a tubular duct that receives cell secretions
Term
connexons
Definition
the fluid-filled tunnels formed between cells which allow diffusion of small molecules, nutrients & wastes and enable nerve & muscle impulses to spread rapidly
Term
absorption
Definition
the intake of fluids or other substances such as digested food from the intestinal tract
Term
gap junctions
Definition
contain the membrane proteins called connexins which form tiny fluid-filled tunnels called connexons that connect neighboring cells allowing transfer of chemical & electrical signals; the plasma membranes are not fused together
Term
avascular
Definition
The name for the property of a tissue having no blood supply of its own
Term
nervous tissue
Definition
detects changes in a variety of conditions inside & outside the body; responds by generating action potentials (nerve impulses) that activate muscular contractions and glandular secretions
Term
tight junctions
Definition
re weblike strands of transmembrane proteins that fuse the outer surfaces of adjacent plasma membranes to seal off passageways between adjacent cells; prevent passage of substances between cells
Term
laminin
Definition
the protein found in the basement membrane to which integrins from cells attach
Term
endoderm
Definition
the primary germ layer that gives rise to the gastrointestinal tract, urinary bladder, urethra and respiratory tract
Term
stratified columnar epithelium
Definition
an epithelial tissue having several layers of irregularly shaped cells; the apical cells are columnar; its function is protection & secretion
Term
simple columnar epithelium
Definition
the tissue in which cells appear like columns (taller than they are wide); cell nuclei are oval & located near the basal surface of the cells.
Term
endothelium
Definition
the simple squamous epithelium which lines the heart, blood vessels, lymphatic vessels.
Term
simple gland
Definition
a gland whose duct does not branch
Term
Holocrine glands
Definition
accumulate their secretory products in their cytosol; as the secretory cell matures it ruptures & becomes the secretory product; the sloughed off cell is replaced by a new cell (sebaceous glands of the skin).
Term
Nonciliated simple columnar epithelium
Definition
the tissue which contains 2 types of cells: ones with microvilli at their apical surfaces & goblet cells
Term
stratified cuboidal epithelium
Definition
an epithelial tissue having 2 or more layers of cells of which the cells in the apical layer are cube-shaped; function is protection & limited secretion & absorption.
Term
transitional cells
Definition
change shape, from flat to cuboidal & back as organs such as the urinary bladder stretch to a larger size and then collapse to a smaller size
Term
Nonkeratinized stratified squamous epithelium
Definition
an epithelial tissue in which cells in the apical layer are flat; those of the deep layers vary from cuboidal to columnar; the basal cells undergo cell division & are pushed upward toward the apical layer; this tissue does not contain keratin in the apical layer and remains moist; found lining the mouth & esophagus.
Term
mesothelium
Definition
he simple squamous epithelium which forms the epithelial layer of the serous membranes
Term
Simple cuboidal epithelium
Definition
he simple squamous epithelium which forms the epithelial layer of the serous membranes
Term
Pseudostratified nonciliated columnar epithelium
Definition
an epithelial tissue which has no cilia or goblet cells
Term
Pseudostratified ciliated columnar epithelium
Definition
an epithelial tissue in which the cells that extend to the surface have cilia or secrete mucus (goblet cells)
Term
adipocytes
Definition
store triglycerides (fats); the are found deep to the skin and around organs such as the heart and kidneys; they are also called adipose cells.
Term
squamous cells
Definition
re arranged like floor tiles & are thin, which allows for the rapid passage of substances through the cells
Term
Keratinized stratified squamous epithelium
Definition
an epithelial tissue in which cells in the apical layer are flat; those of the deep layers vary from cuboidal to columnar; the basal cells undergo cell division & are pushed upward toward the apical layer where they dehydrate and contain a layer of keratin (a tough, fibrous protein).
Term
extracellular matrix
Definition
the material located between the widely spaced cells in connective tissues.
Term
extracellular matrix
Definition
the material located between the widely spaced cells in connective tissues.
Term
apocrine glands
Definition
accumulate their secretory product at the apical surface of the secreting cell; then that portion of the cell pinches off from the rest of the cell to release the secretion; the remaining part of the cell repairs itself & repeats the process.
Term
multicellular glands
Definition
composed of many cells that form a distinctive microscopic structure or macroscopic organ; their ducts may be branched or unbranched; their secreting portions may be tube shaped or flask shaped.
Term
ciliated simple columnar epithelium
Definition
an epithelial tissue which has cells with cilia at its apical surface & goblet cells; this tissue is found in the respiratory tract
Term
microvilli
Definition
inger-like cytoplasmic projections which increase the surface area of the plasma membranes of cells
Term
compound gland
Definition
a gland which has a duct that branches
Term
columnar cells
Definition
much taller than they are wide, like columns, & protect underlying tissues; their apical surfaces may have cilia or microvilli; they are often specialized for secretion and absorption.
Term
unicellular glands
Definition
single-celled such as goblet cells which secrete directly onto the apical surface of a lining epithelium
Term
fibroblasts
Definition
large, flat cells with branching processes which are present in several connective tissues; they secrete fibers and certain components of the ground substance of the extracellular matrix.
Term
mast cells
Definition
white blood cells that are abundant along blood vessels that supply connective tissue; they produce histamine which is part of the body's inflammatory reponse; they can also bind to, ingest, & kill bacteria.
Term
simple squamous epithelium
Definition
the tissue in which the nucleus of each cell is a flattened oval or sphere and is centrally located; found at sites where the processes of filtration (blood in kidneys) or diffusion (oxygen into capillaries) occur; this tissue is NOT found in body areas that are subject to mechanical stress (wear & tear).
Term
merocrine glands
Definition
secretions are synthesized on ribosomes attached to rough ER; processed, sorted & packaged by the Golgi complex; and released from the cell in secretory vesicles via exocytosis.
Term
cuboidal cells
Definition
as tall as they are wide and are shaped like cubes or hexagons; they may have microvilli at their apical surfaces & function in either secretion or absorption
Term
transitional epithelium
Definition
an epithelial tissue in which the cells in apical layer range from squamous (when stretched) to cubiodal (when relaxed); its function is to permit distension
Term
exocrine glands
Definition
secrete their products into ducts that empty onto the surface of a covering & lining epithelium such as the skin or the lumen of a hollow organ
Term
macrophages
Definition
develop from white blood cells called monocytes; they are cells with an irregular shape & short branching projections; they can engulf bacteria & cellular debris by phagocytosis.
Term
elastic connective tissue
Definition
a connective tissue where branching elastic fibers predominate; fibroblasts are present in the spaces between the fibers; it is a strong tissue.
Term
keratan sulfate
Definition
a GAG found in the cornea of the eye
Term
glycosaminoglycans
Definition
large organic polysaccharide molecules which occur in the ground substance of connective tissues; they trap water which makes the ground substance more jellylike
Term
aerolar connective tissue
Definition
one of the most widely distributed connective tissues in the body; has all 3 types of fibers arranged randomly; makes up part of the subcutaneous layer.
Term
perichondrium
Definition
a covering of dense irregular connective tissue that surrounds the surface of most cartilage
Term
chondrocytes
Definition
the cells of mature cartilage occuring singly or in groups within lacunae
Term
dense connective tissue
Definition
a type of connective tissue which contains more numerous, thicker & denser fibers but fewer cells than loose connective
Term
adipose connective tissue
Definition
a connective tissue whose cells, derived from fibroblasts, are called adipocytes which store trigycerides; this tissue is found where ever areolar connective is located.
Term
fibrocartilage
Definition
has chondrocytes scattered among thick bundles of collagen fibers; it lacks a perichondrium; it is the strongest of the cartilages; it is found in the intervertebral discs
Term
osseous tissue
Definition
Bones, which are organs composed of several different connective tissues, also called
Term
ground substance
Definition
the component of connective tissue between the cells & fibers; it may be fluid, semifluid, gelatinous, or calcified; it supports cells, binds them together, stores, water & provides a medium through which substances are exchanged between blood & cells; it plays an active role in how tissues develop, migrate, proliferate, change shape and also in how they carry out their metabolic functions.
Term
plasma cells
Definition
develop from white blood cells called B lymphocytes; they secrete antibodies which are proteins that attack or neutralize foreign substances in the body; they are an important part of the body's immune response.
Term
fibroconectin
Definition
the main adhesion protein in connective tissue which binds to both collagen fibers and ground substance linking them together; it also attaches cells to the ground substance.
Term
dermatan fulfate
Definition
a GAG found in the skin, tendons, blood vessels & heart valves
Term
hyaluronic acid
Definition
a viscous, slippery substance that binds cells together, lubricates joints, and helps maintain the shape of the eyeballs; it does not combine with proteins
Term
dense irregular connective tissue
Definition
has collagen fibers that are irregularly arranged; found in parts of the body where the pulling forces are exerted in various directions such as the dermis of the skin or the pericardium of the heart.
Term
dense regular connective tissue
Definition
has bundles of collagen fibers that are regularly arranged in parallel patterns that provide great strength to with stand pulling along the axis of the fibers; fibroblasts appear in rows between the fibers; found in tendons & ligaments.
Term
interstitial growth
Definition
growth from within cartilage due to division of existing chondrocytes; this growth occurs during childhood & adolescence.
Term
collagen fibers
Definition
strong flexible fibers which resist pulling forces & often occur in parallel bundles; formed from the protein collagen & found in most types of connective tissue.
Term
stroma
Definition
the supporting framework of many soft organs; mainly reticular connective tissue which contains many reticular fibers
Term
adhesion proteins
Definition
found in the ground substance; they are responsible for linking components of the ground substance to one another and to the surfaces of cells.
Term
mesenchyme
Definition
mesodermal embryonic cells that give rise to the cells of connective tissue.
Term
reticular fibers
Definition
fine bundles of collagen coated with glycoprotein; much thinner than the collagen bundles; form branching networks providing support & strength and help from the basement membrane.
Term
cartilage
Definition
consists of a dense network of collagen & elastic fibers embedded in chondroitin sulfate, a gel-like component of the ground substance; stonger than loose & dense connective tissues.
Term
reticular connective tissue
Definition
consists of fine interlacing reticular fibers & reticular cells; it forms the stroma of soft organs; helps bind together smooth muscle cell
Term
elastic cartilage
Definition
chondrocytes located within the threadlike network of elastic fibers; it does have a perichondrium; it provides both strength & elasticity.
Term
appositional growth
Definition
growth at the outer surface of cartilage; cells in the inner layer of the perichondrium differentiate into chondroblasts which secrete matrix; this growth begins later than interstitial growth and continues through adolescence.
Term
elastic fibers
Definition
smaller in diameter than collagen fibers; they branch & form a network; composed of the protein elastin surrounded by the glycoprotein fibrillin; can stretch to 150 % of their relaxed length without breaking.
Term
proteoglycans
Definition
very large molecules which are a combination of GAGs and protein; the core is protein and the GAGs project from the protein like bristles of a bottle brush
Term
hyaline cartilage
Definition
the most common type of cartilage; it has thin, fine collagen fibers in a resilient gel; chondrocytes are found in lacunae; it is mostly surrounded by perichondrium; provides flexibiliy & support and reduces friction & shock.
Term
loose connective tissue
Definition
a type of connective tissue having fibers that are loosely intertwined between cells; includes areolar, adipose & reticular connective
Term
lacunae
Definition
the spaces in the extracellular matrix of cartilage and bone.
Term
chondroitin sulfate
Definition
a GAG which provides support and adhesiveness in cartilage bone skin & blood vessels
Term
serous membranes
Definition
line body cavities that do NOT open directly to the exterior and cover the organs that lie within those cavities
Term
lamellae
Definition
concentric rings of extracellular matrix containing mineral salts which give bone its hardness and collagen fibers which give bone its strength; the rings are parts of an osteon.
Term
visceral layer
Definition
the layer of a serous membrane which covers and adheres to the organs within the cavity.
Term
cardiac muscle tissue
Definition
striated, branching, involuntary, has one centrally located nucleus per fiber and the fibers attach to one another by intercalated discs which have both desmosomes and gap junctions.
Term
smooth muscle tissue
Definition
usually involuntary, nonstriated with a single, centrally located nucleus in a small spindle-shaped fiber
Term
excitable cells
Definition
Neurons and muscle cells which exhibit electrical excitability, the ability to respond to certain stimuli by producing actions potentials, are called:
Term
osteocytes
Definition
mature bone cells which are found in lacunae within the extracellular matrix of bone are called
Term
lymph
Definition
the extracellular fluid that flows in lymphatic vessels; it is a connective tissue consisting of several types of cells in a clear liquid matrix that is similar to blood plasma but has fewer proteins.
Term
thrombocytes
Definition
cell fragments in blood that participate in blood clotting.
Term
neuroglia
Definition
Nerve tissue cells which do NOT generate or conduct nerve impulses are called ; their function is to support the activity of neurons.
Term
trabeculae
Definition
columns of bone within spongy bone; red bone marrow is found in the spaces between the columns.
Term
blood plasma
Definition
he liquid extracellular matrix of blood; it is a pale yellow fluid consisting mostly of water which has a wide variety of substances dissolved in it
Term
fibrosis
Definition
he process of scar tissue formation when fibroblasts are active in the tissue repair.
Term
compact bone
Definition
the strongest osseous tissue having the osteon as the basic structural unit; this type of tissue is found in long bones and the surfaces of all bones.
Term
serous fluid
Definition
a watery lubricant that allows organs to glide easily over one another or to slide against the walls of cavities.
Term
spongy bone
Definition
consists of columns of bone called trabeculae which contain lamellae, osteocytes, lacunae and canaliculi; it does not have osteons
Term
tissue regeneration
Definition
the replacement of worn-out, damaged or dead cells by parenchymal cell
Term
canaliculi
Definition
networks of small canals projecting out from the lacunae and containing the processes of osteocytes; they provide routes for nutrients to reach the osteocytes and for wastes to be removed from them.
Term
osteon
Definition
consists of concentric rings of extracellular matrix of mineral salts and collagen fibers; lacunae in the matrix contain osteocytes; projecting from the lacunae are small canals containing the processes of osteocytes; a central canal contains blood vessels and nerves.
Term
mucous membranes
Definition
line body cavities that open directly to the exterior; they are a barrier to microbes; their connective tissue layer is areolar connective called the lamina propria.
Term
membranes
Definition
flat sheets of pliable tissue that cover or line parts of the body
Term
synovial membranes
Definition
line the cavities of freely moving joints and contain connective tissue but no epithelium; these cavities are not open to the exterior of the body
Term
cell body
Definition
the part of a neuron which contains the nucleus and organelles
Term
leukocytes
Definition
blood are the cells that are involved in phagocytosis, immunity and allergic reactions
Term
dendrites
Definition
he parts of a neuron which receive stimuli; they are usually short, tapering highly-branched cell processes which are connected to the cell body
Term
parietal layer
Definition
the layer of a serous membrane which is attached to and lines the walls of the cavity
Term
synovial fluid
Definition
lubricates and nourishes the articular cartilage covering the bones at movable joints and contains macrophages that remove microbes and debris from the joint cavity.
Term
erythrocytes
Definition
cells in blood which carry oxygen from the lungs to the tissues and carbon dioxide from the tissues to the lungs.
Term
axon
Definition
a neuron is a thin cylindrical process that may be very long and carries the nerve impulse to another neuron or another tissue; there is usually only one of these per neuron.
Term
blood tissue
Definition
a connective tissue with a liquid extracellular matrix and formed elements (cells).
Term
lamina propria
Definition
the connective tissue layer of mucous membranes; it is composed of areolar connective tissue
Term
muscular tissue
Definition
consists of elongated cells called fibers which use ATP (adenosine triphosphate) to generate force producing movements, maintaining posture and generating heat.
Term
neurons
Definition
nerve cells which are sensitive to various stimuli which they convert into electrical signals called action potential or nerve impulses
Term
skeletal muscle tissue
Definition
usually attached to bone of the skeleton, is voluntary (under conscious control), is striated, is a contractile tissue and the fibers are cylindrical with cell nuclei at the periphery of the fiber.
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