Term
| What is the origin of neutrophils and where do they go from there? |
|
Definition
produced in the bone marrow,
released into blood, circulate briefly, and migrate into tissue spaces or on to epithelial surfaces such as those in the respiratory, digestive, or urogenital tracts |
|
|
Term
| What is the transit time for neutrophils? |
|
Definition
|
|
Term
| How long does the marrow maintain mature neutrophils in storage? |
|
Definition
|
|
Term
| What are Colony-Stimulating Factors? |
|
Definition
| They govern the proliferation and maturation of immature neutrophils in the marrow |
|
|
Term
| What produces and releases CSFs? |
|
Definition
| Injury or bacterial invasion of tissue |
|
|
Term
|
Definition
| continuum of cell division, differentiation, and maturation |
|
|
Term
| How long do neutrophils circulate in the blood for? |
|
Definition
|
|
Term
| What are the two compartments that neutrophils go into? |
|
Definition
circulating neutrophil pool and
a marginal neutrophil pool |
|
|
Term
| What do the neutrophils in the circulating pool do? |
|
Definition
| circulate with other blood cells and are measured in the CBC |
|
|
Term
| What is the function of the marginal neutrophil pool? |
|
Definition
consists of neutrophils that
adhere intermittently to endothelium especially in small veins and capillaries. These cells are not counted in the CBC |
|
|
Term
| Which neutrophil pool is counted in the CBC? |
|
Definition
| Circulating neutrophil pool |
|
|
Term
| What is the ratio of neutrophils in the circulating to marginal pools for dogs? |
|
Definition
|
|
Term
| What is the ratio of neutrophils in the circulating to marginal pools for cats? |
|
Definition
|
|
Term
| How long do neutrophils survive for in tissues? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| How are neutrophils destroyed? |
|
Definition
| by the liver, spleen, and bone marrow by resident macrophages |
|
|
Term
| What are factors that influence the numbers of circulating neutrophils? |
|
Definition
–Bone marrow production and release.
–Exchange between circulating neutrophil pool Exchange between circulating neutrophil pool
and marginal neutrophil pool.
– Migration into tissue |
|
|
Term
| Primary function of neutrophils? |
|
Definition
| primary defense against invasion of tissues by microorganisms. |
|
|
Term
What can cause a false decrease in
WBC count? |
|
Definition
|
|
Term
|
Definition
decrease in the absolute number of
neutrophils |
|
|
Term
| When does neutropenia occur? |
|
Definition
| absolute count is less than 3000 -- 4000/μl |
|
|
Term
| Neutropenia is the most frequent cause of what? |
|
Definition
|
|
Term
| What is the function of Eosinophils? |
|
Definition
| systemic hypersensitivity reactions such as allergies or parasites |
|
|
Term
|
Definition
| a reduction in circulating eosinophils |
|
|
Term
|
Definition
| increase in absolute eosinophil count |
|
|
Term
| What are the 3 causes of Eosinophilia? |
|
Definition
| allergy, parasites and Granulomatous inflammation |
|
|
Term
| What are the characteristics like in an Eosiniphil canine granule? |
|
Definition
| orange/red, numerous, round, and small |
|
|
Term
| What are the characteristics like in an Eosiniphil feline granule? |
|
Definition
| pale pink and rod--shaped |
|
|
Term
| What is the function of Basophils? |
|
Definition
They contain histamine and
heparin; Heparin inhibits coagulation and Histamine release has an important role in hypersensitivity reactions |
|
|
Term
|
Definition
| reduction in circulating Basophils |
|
|
Term
|
Definition
| increase in circulating basophils |
|
|
Term
| What can cause basophilia? |
|
Definition
| allergies, parasites, hyperlipemia |
|
|
Term
In felines what color are the granules of a basophil?
How many are there? |
|
Definition
| lavender/blue; they are numerous |
|
|
Term
In canines what color are the granules of a basophil?
How many are there? |
|
Definition
| bluish; may be sparse or absent |
|
|
Term
| What can cause a stress leukogram? |
|
Definition
| stress, diseases, steriods |
|
|
Term
| What do stress leukograms cause? |
|
Definition
| LEON = lymphopenia, eosinopenia, occasional monocytes, neutrophilia |
|
|
Term
|
Definition
|
|
Term
| Where is the adrenal gland located? |
|
Definition
|
|
Term
| What kinds of adrenaline does the adrenal gland produce? |
|
Definition
|
|
Term
| What are examples of neutropenia with monocytosis? |
|
Definition
|
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