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The Reproductive System
Regulation of Sex Hormones
9
Anatomy
Undergraduate 4
08/30/2008

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Term
In step 1, What happens in the hypothalamus?
Definition
The hypothalamus secretes GnRH.
Term
In step 2, Where does the GnRH travel to, and how does it get there?
Definition
GnRH passes through the blood (hypothalamohypophyseal portal) to the Anterior Pituitary gland (A.P.)
Term
In step 3, what does GnRH do?
Definition
GnRH stimulates the A.P. gland causing it to secrete two Gonadotropins.
Term
What are the names of the two hormones created in step 3?
Definition
A.P. secretes L.H. & F.S.H.
L.H. = Leydig cell stimulating hormone.
F.S.H. = Forming sperm cell.
Term
In step 4, where does each hormone travel to?
Definition
L.H. & F.S.H. travel to the testes. Once they are there each hormone plays a different role.
Term
In step 4a, What role does L.H. play in the testes?
Definition
L.H. binds to the leydig cells inside the testes surrounding the seminiferous tubules. & stimulates the leydig cells.

This causes the leydig cells to increase the rate of making testosterone & secreting testosterone.
Term
Where does the testosterone end up traveling to from the leydig cells?
Definition
Testosterone passes through the blood & back to the hypothalamus.

Testosterone has a negative feedback on the hypothalamus which stops GnRH.

Testosterone has a negative feedback on the A.P. which reduceds L.H. & F.S.H. secretions.
Term
In step 4b, What roles does the F.S.H. play in the testes?
Definition
F.S.H. binds to the sertoli cells inside the seminiferous tubules in the testes.

F.S.H stimulates the sertoli cells causing the sertoli cell to secrete Inhibin and to increase spermatogenesis.
Term
Where does the Inhibin end up traveling to from the sertoli cells?
Definition
The inhibin passes to the A.P. gland.

Inhibin has a negative feedback effect on the A.P. which reduces the secretion F.S.H.
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