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The Epidermis
Major Cell Types
4
Anatomy
Graduate
01/15/2013

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Term
Keratinocytes
Definition
most numerous; arranged in 4-5 layers; produce keratine; protects tissues from microbes, heat and H2O loss; produce lamellar granules
Term
Melanocytes
Definition
deepest layer of epidermis; produce melanin, protective melanin to keratinocytes (are vulnerable to UV); transfer melanin to keratinocytes via cytocrine secretion
Term
Langerhans cells
Definition
small fraction of epidermal cells; star shaped wandering macrophage derived from bone marrow and which infiltrate the epidermal layers and serve the immune functions of phagocytosis and antigen-presenting; easily damaged by UV radiation
Term
Merkel Cells
Definition
least numerous; deepest layer resembling a spike hemisphere which communicates with the disk-like sensory terminal of a neuron; the combined structure is termed a Merkel or tactile disc they are the receptors for light or discriminative touch
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