Term
| What is the purpose of inflammation? |
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Definition
| A complex progression of vascular and interstitial tissue changes that develop in response to tissue injury. |
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Term
| What are three categories of inflammation? |
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Definition
| Acute, Chronic, and Healing/Tissue Repair |
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Term
| What are the 5 Signs of Acute Inflammation and what is the mechanism of each? |
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Definition
| Rubor (vasodilation), Tumor (cellular influx), Calor (increased temperature), Dolor (release of soluble mediators), Loss of normal function (caused by the rest) |
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Term
| Name the most critical event in the pathogenesis of acute inflammation and the mechanism behind it. |
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Definition
| Increased permeability of capillaries and venules due to escape of protein-rich fluid into the tissue |
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Term
| Name the 5 main steps that describe the pathogenesis of acute inflammation |
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Definition
1. Capillaries become abnormally permeable
2. Blood flow increase to site of injury
3. Fluid and cells produce exudate
4. Leukocytes degranulate
5. Activation of sympathetic responses |
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Term
| What do Prostaglandins do and where do they come from? |
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Definition
| Vasodilation; from Endothelial cells |
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Term
| What do Cytokines do and where do they come from? |
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Definition
| Calls of WBCs; from Endothelial cells |
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Term
| What do Procoagulant Factors do and where do they come from? |
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Definition
| Coagulation when necessary; from Endothelial cells |
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Term
| What do Histamine/Seratonin do and where do they come from? |
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Definition
| Increases permeability; from Mast cells degranulation |
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Term
| What do Heparin do and where do they come from? |
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Definition
| Anticoagulant; from Mast cells degranulation |
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Term
| What do Leukotrienes do and where do they come from? |
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Definition
| Create pain; from Mast cells degranulation |
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Term
| What do Antimicrobial Factors do and where do they come from? |
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Definition
| Kill microbes; from Neutrophils |
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Term
| What do Kinins do and where do they come from? |
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Definition
| Vasodilation, permeability, pain; from Neutrophils |
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Term
| What do Proteases do and where do they come from? |
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Definition
| Breakdown tissues/proteins; from Neutrophils |
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Term
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Definition
| Creating new blood cells in the body |
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Term
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Definition
| Generation of lymphocytes |
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Term
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Definition
| An inflammatory, extravascular fluid that is low in protein, WBCs and other cellular debris |
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Term
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Definition
| An inflammatory, extravascular fluid that is high in protein, WBCs and other cellular debris |
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Term
| What are the four main types of exudates? |
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Definition
| Fibrinous, Mucous, Purulent, Serous Exudate |
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Term
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Definition
| Initial, watery exudate found in most acute inflammatory reactions. Dilutes irritants and eases migration of inflammatory cells to foloow |
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Term
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Definition
| Pale tan, stringy mesh on the surface of tissues, helps form clots and a framework for fibroblasts |
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Term
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Definition
| Contains antibodies and lysozymes |
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Term
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Definition
| Bacterial infections are the most common cause. Mainly fluid, albumin, and plasma proteins |
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