Term
|
Definition
restoration of tissue structure and function after and injury
usually both regen and healing contribute |
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Term
| Regeneration (definition) |
|
Definition
replacement of normal tissue components and return to a normal state
minimal trauma or short term |
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Term
|
Definition
results in scar (fibrous tissue) formation if:
tissues are incapable of complete reconstruction
OR
the supporting structures are severely damaged
large trauma or long term |
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Term
|
Definition
cellular proliferation
cellular interaction
cellular and ECM interactions |
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Term
|
Definition
capacity for continuous dividing
(ie. gut lining) |
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Term
|
Definition
limited capacity to regenerate
(ie, kidney, liver, pancreas) |
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Term
|
Definition
slow cycling,
following wounding make an increased and sustained contribution |
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Term
| Transit Amplifying/Progenitor Cells in repair |
|
Definition
| rapidly dividing - take care of daily maintenance |
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Term
|
Definition
network surrounding cells
synthesised locally by mesenchymal cells
in DERMAL layer |
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Term
|
Definition
tissue that supports, binds, or separates other tissues or organs
composed of ECM and MESENCHYMAL CELLS |
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Term
|
Definition
| skin wound to just epidermis - no scar |
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Term
|
Definition
| skin wound to epidermis and dermis |
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|
Term
| 3 overlapping phases of wound healing |
|
Definition
inflammation
formation of granulation tissue in dermis
fibroblasts deposit ECM |
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Term
|
Definition
formation of new blood vessels
Endothelial progenitor cells (EPC) mobilize from bone marrow to for new vessels
OR
new vessels form from pre-existing vessels |
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Term
|
Definition
tissue repair begins within 24 hours
Granulation tissue forms within 3-5 days
pink, soft, granular gross appearance |
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Term
|
Definition
a clean, uninfected surgical incision closed by sutures
only focal disruption of epithelial basement membrane
epithelial regen predominates fibrosis |
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Term
|
Definition
tissue loss more extensive: abscess, ulceration, large wounds
intense inflammation and abundant granulation tissue |
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|
Term
| What prevents/delays healing |
|
Definition
| infection, malnutrition, mechanical factors, anaemia, age/physical status, dehydration, wound fluid, inapropriate dressing, foreign bodies, neoplasia |
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|
Term
| Wound healing in reptiles |
|
Definition
SLOW
sutures 4-6 weeks
ecdysis promotes healing
maintenance at upper level of temperature range promotes healing |
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