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Rotation 7 - CNS drugs
Pharmacology
59
Veterinary Medicine
Undergraduate 3
03/02/2014

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Cards

Term
What are stimulants most used for?
Definition
to stimulate respiration or speed arousal from anesthesia
Term
What does analeptics mean?
Definition
a restorative drug
Term
What are CNS stimulant drugs?
Definition
Doxapram HCl (Dopram) and Theophylline (Theodur)
Term
What is the action of Doxapram (Dopram)?
Definition
stimulates the respiratory center in the medulla
Term
What are the clinical uses of Doxapram (Dopram)?
Definition
a. respiratory arrest
b. arousal from anesthesia
c. stimulate respiration in the newborn
1. SQ, sublingual area, Umbilical vein
Term
Theophylline is in the same family of drugs as what?
Definition
caffeine
Term
What is the action of Theophylline?
Definition
increases irritability of cerebral cortex
Term
What are the clinical uses of Theophylline?
Definition
2. used primarily as bronchodilator
a. also has diuretic and stimulatory effect
b. will prevent water reabsorption at the kidney tubules
c. will dilate the bronchi and stimulate blood flow to the coronary artery
Term
Which drug is similar to Theophylline and has a shorter duration of action?
Definition
Aminophylline
Term
What are the clinical uses of Aspirin?
Definition
analgesic, anti-inflammatory, antipyretic, reduction in platelet aggregation
Term
What is an antipyretic?
Definition
reduces fever by acting on the temperature regulating area in the hypothalamus
Term
How does Aspirin relieve pain?
Definition
relieves pain by elevating the pain threshold in the thalamus
Term
How does Aspirin function as an anti-inflammatory?
Definition
inhibits production of prostaglandin, histamine, serotonin and bradykinin
Term
What are signs of Aspirin toxicity?
Definition
1. anorexia
2. vomiting
3. ataxia
4. bone marrow suppression
5. ulceration of mucus membranes (gastric)
6. hepatoxicity
7. shock, death
Term
What can be used to decrease the chances of GI ulceration?
Definition
Sucralfate and misoprostil (Cytotec)
Term
What kind of drug is Acetaminophen (Tylenol)?
Definition
non-narcotic analgesic, not in the salicylate family
Term
How does Acetaminophen (Tylenol) work (since it is technically not an NSAID)?
Definition
reduces the perception of pain in the thalamus of the brain
Term
What are the clinical uses of Acetaminophen (Tylenol)?
Definition
good analgesic and antipyretic, elevates the pain threshold, not irritating to the gastric mucosa, an be administered for a long period of time
Term
What species should Acetaminophen (Tylenol) never be given to at any dose?
Definition
cats
Term
What is the treatment if a cat is given Acetaminophen (Tylenol?
Definition
acetylcystine, Vitamin C
Term
What kind of drug is Phenylbutazone?
Definition
non-narcotic analgesic
Term
What are the uses of Phenylbutazone?
Definition
anti-inflammatory, antipyretic, analgesic
Term
What are the uses of Ibuprofen (Motrin, Advil)?
Definition
analgesic and anti-inflammatory
Term
What can Ibuprofen (Motrin, Advil) cause?
Definition
gastric irritation and not recommended because of potential ulceration problems
Term
What is the mechanism of action for Carprofen (Rimadyl)?
Definition
appears to inhibit cyclooxygenase (COX) II and spare COX I
1. COX II inhibition will inhibit inflammation
2. COX I sparing effects will minimize effects the stomach and kidney
Term
What kind of drug is Etodolac (EtoGesic)?
Definition
NSAID
Term
What are the actions of Etodolac (EtoGesic)?
Definition
anti-inflammatory, anti-pyretic and analgesic
Term
What does Ketoprofen (Ketofen) inhibit?
Definition
COX-1 and COX-2
Term
What has Ketoprofen (Ketofen) been associated with?
Definition
decreased platelet adhesion and increases in bleeding times
Term
Fericoxib (Previcox) is an NSAID that is approved for use of what species only?
Definition
dogs
Term
Morphine is what kind of drug?
Definition
narcotic analgesic, schedule II drug
Term
How is Morphine metabolized?
Definition
the liver
Term
What kind of drug is Butorphanol (Torbutrol, Torbugesic)?
Definition
a derivative of opium - analgesic
Term
What schedule is Butorphanol (Torbutrol, Torbugesic)?
Definition
IV
Term
What are uses for Butorphanol (Torbutrol, Torbugesic)?
Definition
-centrally acting cough suppressant (antitussive)
-effective as an analgesic while producing mild sedation
Term
What drug is similar to oxymorphone?
Definition
hydromorphone (Dilaudid)
Term
What schedule is hydromorphone (Dilaudid)?
Definition
II - controlled
Term
What are the clinical uses of hydromorphone (Dilaudid)?
Definition
1. sedative
2. analgesic
3. preanesthetic
Term
What kind of drug is the Fentanyl patch?
Definition
synthetic opioid with 100 times the potency of morphine
Term
How long do Fentanyl patches last?
Definition
72 hrs
Term
What kind of drug is Hydrocodone (Hycodan)?
Definition
a narcotic antitussive
Term
What schedule is Hydrocodone (Hycodan)?
Definition
III
Term
What are side effects of Hydrocodone (Hycodan)?
Definition
side effects
1. sedation
2. vomiting
3. constipation
4. opiates may cause excitement in cats
Term
What kind of drug is Tramadol?
Definition
an opioid like drug
Term
What are the uses of Tramdol?
Definition
c. may be used as a cough suppressant (antitussive)
d. exerts opioid like effects in the spinal cord
Term
What are the narcotic reversing agents?
Definition
Nalorphine (Nalline) and Naloxone (Narcan)
Term
Which drug is best used to reverse Morphine?
Definition
Nalorphine (Nalline)
Term
What are the drugs for control of seizures?
Definition
Phenobarbitol, Primidone, Diazepam (Valium), Pentobarbital, Potassium bromide, levetiracetam (Keppra)
Term
What is the action of Phenobarbitol?
Definition
elevates the seizure threshold
Term
What is the major dose dependent side effect of Pheno?
Definition
respiratory depression
Term
What are other side effects of Pheno?
Definition
b. polyuria
c. polydipsia
d. polyphagia
e. drowsiness
Term
Pheno can cause what to the liver?
Definition
may cause liver enzyme induction and damage to liver cells
Term
What drug is converted to phenobarbital in the liver?
Definition
Primidone
Term
What drug is more likely to cause liver damage than phenobarbitol?
Definition
Primidone
Term
Primidone is recommended when?
Definition
when phenobarbital is unable to control seizures
Term
What drug is best to use for IV emergency seizure control to stop an active seizure?
Definition
Diazepam (Valium)
Term
What drug is used via IV to treat status epilepticus?
Definition
Pentobarbital
Term
Which drug is used in cases that do not respond to Pheno?
Definition
Potassium bromide
Term
Which drug is the choice for cats with epilepsy with few side effects?
Definition
levetiracetam (Keppra)
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