Icosahedra, RNA virus, single stranded, + sense, linear, NO ENVELOPE.  ***multiplies quickly and kills cells***

replication and sassembly in cytoplasm

rapidly cytolytic infection is generally acute

Multiple serotypes may produce same disease syndrome

***very little or no cross-protections between serotypes***

Examples: Common Cold and Foot and mouth disease.

Icosahedral, RNA virus, single stranded, + sense, Linear, NO envelope, has "cup" like fatures or Hollow Capsomeres

replication and assembly in the cell cytoplasm and virions are released via cell lysis

***need to decontaminate the environment***

Envelope, Icosahedral, single stranded, + sense,linear

**attack arterioles and endothelial of blood vessel walls**

PRIMARY HOST CELLS ARE MACROPHAGES

Replication in cytoplasm and assembly via budding

persistent infections are established

examples: Equine Viral Arteritis Edema of the Scrotum

Equine Viral Arteritis Aborted Fetus

very small,NO envelope, Icosahedral,single stranded, + sense, linear

Similar in properties to Picornoviridae

Enveloped, icosahedral, single stranded, + sense, linear

**very fragile, no inclusion bodies**

replication in cytoplasm and assembly via budding

infection is acute and cytolytic

***VERY DEADLY***

ex: Eastern Equine Encephalitis

Enveloped, icosahedral, single stranded, + sense and linear. replication in cytoplasm.  Envelope for assembly via Endoplasmic Reticulum

True BUDDING is not present

Infection in vertebrates is cytolytic

example YELLOW FEVER, WEST NILE Meningoencephalitis

Enveloped, Icosahedral, single stranded, - sense, and linear

 *** one of the few RNA viruses that replicates in the nucleus***

Intranuclear inclusion bodies

affinity for nervous tissues

labile virion

Retroviridae

BACKWARDS

Enveloped, Icosahedral, single stranded, + sense, linear

DNA transcription from RNA- going backwards to RNA to DNA

***BYOE*** bring your own enzyme- Reverse Transcriptase

sperical enveloped virus with diploid genome- uniqu among viruses

Host remains chronically infected

Integration into host chromosomal DNA by viral integrase present in cucleocapsid

Virus replicated from integrated "provirus" DNA copy

Occurs by budding from Plasma Membrane

***ALL ONCONGENIC RNAviruses belong to this family***

Reoviridae

Respiratory Enteric Orphan

NAKED, Icosahedra, double stranded, linear, SEGMENTED

Medium size

***Possess 2-3 layered capsids***

Segmentation results in genetic reassortment in dual infections

Replication and Assembly in cytoplasm

Produce Acidophilic, intracytoplasmic, perinuclear inclusion bodies

***Inclusion bodies unique to this family because they surround the nucleus***

***Number 1 cause of diarrhea in all species***

resistant in the environment

Naked, Icosahedral, double stranded, linear, segmented (2) segments

Medium size

assembly in cytoplasm, released via cell lysis

STABLE in the environment

No inclusion bodies

Enveloped, HELICAL, single stranded, - sense, linear

3 segments

spherical or pleomorphic enveloped virions

**Replication occurs in the cytoplasm virus bud from Golgi Membranes**

TRANSMITTED VIA ARTHROPODS (arbovirus)

No disease in the rodent, true reservoirs

Labile in the environtment

Mainly Human Virus

Example- Hantavirus

Arenaviridae

(arena=sand)

Helical, segmented, single stranded, - sense

Pleomorphic enveloped

**Envelope has LARGE club shaped peplomers**

HOST CELL = RIBOSOME (sand like)

genome has 2 molecules L and S

replication in cytoplasm assembly via plasma membrane budding

CHRONIC life long in apparent infections in specific rodent reseroir hosts

Enveloped, helical, single stranded, - senes, linear, 6-8 segments

Pleormorphic= spherical or tubular

Envelope contains surface projectiosn with HEMAGGLUTININ or Neuroaminidase activity

**replication takes place in the nucleus and cytoplasm**

No inclusion bodies

Coronoviridae

(Corno=cream)

Enveloped, Helical, single stranded, + sense, linear

club shaped surface peplomers arrange in Fringe with solar Crown appearance

***ONLY HELICAL LINEAR POSITIVE SENSE RNA***

Replciation in cytoplasm, budding via ER and Golgi Membranes

Narrow Host Range

Persistant infections, moderately resistant

No inclusion bodies

100% Fatal, most common FIP

VERY LARGE, Enveloped, Helical, Single Stranded, Linear, - sense

Rhabdoviridae

(rhabdos= rod)

Enveloped, helical, linear, single stranded, - sense

***NO THER VIRUS LOOKS LIKE THIS***

RESEMBLING A BULLET= FLAT ON ONE END AND ROUND ON THE OTHER

replication in cytoplasm, budding from plasma (vesiculoviruses) or intracytoplasmic membranes (lyssaviruses)

Prominenet Cytoplasmic Inclusion Bodies

Broad Host Range

**Rapidly Inactivated by UV Light = VERY FRAGILE**

ex= Negri Bodies

Large, Enveloped, Helical, singles stranded, - sense, linear

**large helical nucleocapsid surrounded by pleomorphic envelope= spherical to filamentous**

PENETRATE BY FUSION WITH PLASMA MEMBRANE

VERY FRAGILE- do not survive well in the environment

CELL TO CELL FUSION, syncytia or multinulceated giant cells

Intracytoplasmic inclusion bodies and intranuclear inclusion bodies

Perisistant infections, labile virions