Shared Flashcard Set

Details

Repro Exam 1
Lecture 2
57
Anatomy
3rd Grade
01/16/2013

Additional Anatomy Flashcards

 


 

Cards

Term
to make an erection cGMP and cAMP do what?
Definition
decrease intracellular Ca- muscle relaxes- more blood flow
Term
2 mechanisms of detumescence
Definition
PDE5->break down cGMP-> more cystolic Ca
sympathetic (NE, EPi)-> more cystolic Ca
Term
what type of ED is not as receptive to sexual stimuli
Definition
psychogenic
Term
different causes of psychogenic ED
Definition
general unresponsive
situational
psychological distress
Term
what are the 4 types of organic ED
Definition
neurogenic
vascular
hormonal
drug induced
Term
neurogenic ED can be due to? -3
Definition
brain injury
peripheral neruopathy
spinal cord injury
Term
4 types of hormonal ED
Definition
decreased testoserone production
hyperprolactinemia
hypothyroidism
hyperthyroidism
Term
Hyperprolacinemia inhbiits _ which decreases what hormone?
Definition
dopamine
GnRH
Term
hypothyroidism leads to ED how? -2
Definition
decreased testosterone->increased prolactin
Term
hyperthyroidism causes ED how
Definition
decreased libido due to increased estrogen
Term
5 drug classes that cause ED
Definition
anticholinergics
antidepressents/psychotics
dopamine antagonists
estrogens/antiandrogen
CNS depressants
antihypertensive agents
Term
how does cigarette smoking cause ED?
alcohol?
Definition
vasoconstriction;
organic and psychogenic
Term
what lab tests do you do for ED -4
Definition
lipids, glucose, testosterone, thyroid
Term
what is first line management for ED?
for what type of ED would it not work for?
Definition
PDE5 inhibitors
-if libido problem- it requries NO and cGMP
Term
how do the PDE5 inhibitors work?
Definition
inhibit break down of cGMP- keep cystolic Ca low
Term
PDE 5 selective for - 3
Definition
genital tissue, tracheal smooth muscle, platelets
Term
PDE6 selective inhibitor might cause? -3
why?
Definition
light sensitivty, blurry vision, loss blue-green color
bc has recpt in retina
Term
PDE 11 selective might cause?
why?
Definition
back pain
bc recpt in skeletal muscle
Term
what is contraindicated for PDE inhibitors?
why?
if still use how long to wait inbtwn?
Definition
use of nitrates
creates hypotension by increase NO
24-48 hrs of seperation
Term
precautions for PDE5 inhibitors-3
Definition
priapism
CAD
vasodilation conditions (hypotension)
Term
common side effects of PDE5 inhibitors-4
Definition
headache, dizzy, face flush, dyspepsia
Term
rare side effects of PDE 5 inhibitors -5
Definition
priapism
hearing imparied
vision imparied
back pain
NAION
Term
CYP 3A4 inhibitors should not be coadmin with?
what are ex of thesE?
Definition
PDE 5 inhibitors
macrolides, azoles
Term
how long do you seperate alpha1 blockers from PDE 5 inhibiors
Definition
4 hours
Term
medications that if coadministered with PDE5 inhibitors could cause hypotension
Definition
antihypertensive
alcohol
Term
counseling tips for PDE5 inhibitor meds-3
Definition
-foreplay
-take on empty stomach
-onset of action
Term
what should you avoid while taking PDE5 inhibitors?
Definition
alcohol
Term
which medication is synthetic prostaglandin E?
Definition
alprostadil
Term
what is the MOA of alprostadil?
Definition
increase cAMP-> decerase Ca->increase blood flow
Term
which type of alprostadil administration has better efficacy
Definition
intracavernosal injection
Term
which type of ED therapy is good for multiple ED etiologies
Definition
alprostadil
Term
what is the dosing schedule for the intracavernosa injection?
Definition
MAX of 3x a week
Term
max dose for MUSE
Definition
2x in 24 hours
Term
duration of erection for alprostadil is directly related to?
Definition
dose
Term
contraindications for alprostadil-3
Definition
penile deformity/priapism
penile implant
-preggo partner w/o condom
Term
Precautions for alprostadil-3
Definition
bleeding disorder
other vasoactive agents
cardiac health
Term
what drug therapy with ED do you not need hepatic and renal adjustments?
which doesnt have drug interactions?
Definition
both= alprostadil
Term
side affects from alprostadil -5
Definition
dizziness, hypotension, pain, priapisim, bleeding
Term
for intracavernosal injection:
storage-
do you reconstitute?
when do you inject?
how long does erection last?
Definition
room temp
yes
5-10 minutes before want erection
lasts 1 hr
Term
what patients do you caution use of the injection alprostadil
Definition
obese, blind, arthritic
Term
for MUSE:
storage-
suggest what before use?
what should you do to help blood flow?
Definition
fridge
empty bladder
sit, stand, walk for 10 minutes after
Term
counseling points for alprostadil-4
Definition
-needs good vision
-rotate sites to avoid hematomas
-low risk of priapism
-can use with VEDs
Term
what is not recommended therapy for secondary ED
Definition
yohimbe
Term
this is indicated fro primary and secodnary hypogonadism
Definition
testosterone
Term
signs of low testosterone/ secodnary ED
Definition
decreased libido, decreased muscle, depression
Term
secondary ED treatment doesnt directly act on ED- its acts to do what?
Definition
increase libido
Term
Goals of secodnary ED treatment-4
Definition
restore muscle
restore sex drive
mood
return testosterone to normal level
Term
what type of testosterone therapy wont be of use for ED?
Definition
oral
Term
caution use of testosterone therapy for 2nd ED for - 2
Definition
prostate cancer
BPH
Term
when using testosterone therapy what do you monitor?
Definition
liver tox
Term
stop testosterone treatment if not working after how long?
Definition
3 mo.
Term
cardio effects of testosterone-3
Definition
edema
HTN
decreased HDL
Term
endocrine efects of testosterone-4
Definition
hypoglycemia
weight gain
Na retention
gynecomastia
Term
what testosterone admin bypasses 1st pass metab
Definition
buccal
Term
what testosterone admin has less frequent dosing?
Definition
IM
Term
this testosterone patch has good absorption but falls off easily?
Definition
scrotal
Term
this testosterone patch increases risk of dermatitis
Definition
non scrotal
Supporting users have an ad free experience!