Term
Definition: Endogenous pigments
-examples? |
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Definition
-arise from normal body compounds
-ex: Lipofuscin, melanin, hemosiderin, bilirubin |
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Term
Definition: Exogenous pigments
-examples? |
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Definition
-arise from materials not natural to the body
-ex: tattoo ink, carbon |
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Term
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Definition
-wear and tear pigment
-yellow-brown pigmented granules composed of lipid residues of lysosomal digestion
-accumulation of products of long-term, excessive oxidation of unsaturated fatty acids by oxygen free radicals
-usually incidental and non-pathogenic in aged animals
-primarily accumulates in neurons, liver, and hart muscle |
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Term
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Definition
-melanin develops naturally in abnormal locations (incidental findings)
-no clinical significance |
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Term
| ________ is common incidental finding in black-faced sheep, calves, and dogs. |
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Definition
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Term
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Definition
| -macrophages that ingest melanin |
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Term
| Definition: Pigmentary incontinence |
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Definition
| -when macrophages ingest melanin that dislodges from epidermal melanocytes and they migrate to the regional lymph nodes |
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Term
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Definition
| -iron storage proteins composed of apoferritin molecules plus iron |
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Term
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Definition
| -an iron storage complex (ferritin aggregate) within cells, especially macrophages, hepatocytes, renal tubular epi, bone marrow, and spleen red pulp |
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Term
| Definition: Hemosiderosis |
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Definition
-accumulation of hemosiderin in tissue
-non-toxic |
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Term
| Hemosiderosis mostly accumulates in macrophages (___________). |
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Definition
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Term
| Definition: Heart-failure cells |
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Definition
| -macrophages in pulmonary alveoli in chronic passive congestion and pulmonary hypertension |
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Term
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Definition
| -common normal finding in cats; also see when iron accumulation more rapid than metabolism |
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Term
| Definition: Icterus (Jaundice) |
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Definition
-accumulation of bilirubin in tissues
-heme breakdown in macrophages to unconjugated bilirubin which is released and circulates in blood |
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Term
| Explain the effects of tattoo ink on lymph nodes. |
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Definition
| -makes them discolored green, red, black, and brown |
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Term
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Definition
-accumulation of carbon pigment in lung
-happens due to inhalation of carbon particles into the lungs: coal miners, urban animals in cities using coal-burning power plants for electricity, etc |
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Term
| Definition: Pneumoconiosis |
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Definition
-disease caused by inhalationof irritant particles such as silicone in coal dust
-no animal disease quivalent |
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