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Physiology II Digestion
Duke's Ch 23
58
Veterinary Medicine
Professional
01/22/2013

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Term
In carnivores, digestion is mainly
Definition
enzymatic and microbial digestion is minimal
Term
Ruminants are
Definition
pregastric fermenters
Term
Horses are
Definition
postgastric fermenters
Term
Transit time is _______ in herbivores than carnivores.
Definition
slower
Term
Those with simple stomachs usually digest
Definition
high energy content
Term
Ruminants and horses eat plant matter which is considered
Definition
low energy content
Term
Continual grazing of horses and ruminants is required due to
Definition
the low energy content of plant matter and for continual musculature contraction of the digestive tract
Term
How do ruminants maintain blood glucose concentration considering very little blood glucose is absorbed under natural fermentative conditions?
Definition
glucose is produced in the liver by short chain fatty acids
Term
Fermantation and SCFA metabolism is ______ efficient than direct absorption of glucose from the gut.
Definition
less
Term
In ruminants, what is formed and often utilized by microorganisms to for microbial protein?
Definition
ammonia and peptides
Term
The major end product of carbohydrate digestion in the horse is ________
Definition
glucose
Term
Layers of Mucosa
Definition
epithelium, lamina propria, muscularis mucosa
Term
Submucosa
Definition
connective tissue, vessels, nerves - submucosal plexus
Term
Muscularis externa
Definition
circular muscle and longitudinal muscle
Term
The serosa is made of
Definition
connective tissue
Term
Two ganglia that have plexuses in the intestinal wall are
Definition
submucosal plexus and the myenteric plexus
Term
The myenteric plexus lies between the
Definition
circular and longitudinal muscle layers
Term
Circular muscle _______, while longitudinal muscle ______ __________.
Definition
constricts, runs lengthwise
Term
The myenteric and submucosal plexuses make up the
Definition
ENS - enteric nervous system
Term
Neural control of gut function is controlled by the _____ and _____.
Definition
ANS and ENS
Term
In the ruminant, urea - non protein nitrogen can be utilized to synthesize _______ _______ and takes place in the __________.
Definition
microbial protein, forestomach
Term
Why are horses less efficient at digestion than ruminants?
Definition
Passage rates through the large intestine are faster in the horse than in ruminants meaning there is less time spent digesting, resulting in loss of efficiency
Term
Layers of the intestinal wall in their order of appearance from lumen to serosa.
Definition
Lumen, mucosa, submucosa, muscularis externa, serosa
Term
The submucosal plexus lies between the
Definition
muscularis externa and the submucosa
Term
What is the orientation of the two smooth muscle layers?
Definition
The innermost layer is circular and the outermost layer is longitudinal
Term
What are the receptors for preganglionic neurotransmitters?
Definition
nicotinic/cholenergic receptors for ACh
Term
What are the receptors for postganglionic neurotransmitters?
Definition
adrenergic(S), muscarinic(PS) for Ach, as well as somatostatin, neuropeptide Y (NPY) receptors
Term
What is the route and potential for sympathetic sensory (afferent) neurons?
Definition
the fibers synapse at the dorsal root ganglion in the spinal cord
Term
Where do parasympathetic, preganglionic neurons synapse? What is the major transmitter at this location?
Definition
at the ganglion of the myenteric and submucosa plexuses and use ACh as their main neurotransmitter
Term
Can basic peristalic reflex take place with all CNS connections severed?
Definition
Yes
Term
Cholinergic innervation
Definition
increases contractile activity and secretion
Term
Adrenergic innervation
Definition
decreases contractile ability, motility, secretions, blood flow, and can also can inhibit Ach release
Term
Name two ways in which adrenergic stimulation can exert its inhibitory effects
Definition
by inhibiting Ach release and can inhibit epithelium and muscle directly
Term
What are the ENS neurons that contain inhibitory substances known as?
Definition
NANC – noncholinergic, nonadrenergic inhibitory neurons
Term
Ileus
Definition
intestinal obstruction caused by inhibition of motor activity (hypomotility) can be due to surgery, peritonitis, or mechanical obstruction
Term
Name the reflex associated with simple obstruction
Definition
descending inhibition
Term
Descending inhibition
Definition
when an obstruction occurs motility is increased cranially while motility is decreased caudally from the point of obstruction; cholinergic nerves are involved as well as NANC neurons
Term
What is the response to persistent obstruction and finally, severe distention?
Definition
longer segments of intestine become inhibited until complete paralysis of the intestinal tract
Term
What substances released from postganglionic adrenergic and enteric nerves induce inhibition?
Definition
NPY - neuropeptide Y and NO - nitrous oxide
Term
Enteroendocrine cells
Definition
arise from neural crest of embryo and distribute thorughout GI to synthesize peptide hormones and amines
Term
Cells that secrete gastrin, secretin, and CCK are located
Definition
in the stomach and proximal small intestine
Term
How are the enteroendocrine secretions transmitted?
Definition
secreted in blood or from cell to immediate vicinity
Term
CCK, gastrin, and secretin
Definition
initiate gastric and intestinal phases of digestion
Term
How does the location of cells secreting enteroglucagon and peptide YY correlate with their function?
Definition
located in the distal small intestine, function as the “ileal brake” that slows gastric emptying and small intestinal transit, promoting increased small intestinal absorption.
Term
Systemic hormones have potent effects on
Definition
water and electrolyte transport in gut and kidney
Term
Resident cells in lamina propria are capable of
Definition
secreting basal amounts of soluable mediators to perform "housekeeping" functions and have local regulatory action on motor, secretory, and barrier function
Term
Prostaglandins and nitrous oxide
Definition
protect and maintain mucosal epithelial barrier and mucosal blood flow
Term
Cytokines
Definition
mediate cell to cell communication, mostly between leukocytes and stimulate cell and mucosal growth
Term
What are the 4 growth factors present GI tract?
Definition
Epidermal growth factor, transforming growth factor, insulin-like growth factor, and fibroblast growth factor
Term
Histamine and secretin
Definition
are secreted by mast cells and have direct action on smooth muscle cell contractibility and epithelial cell electrolyte secretion
Term
Micro amounts of hydrogen peroxide secreted by phagocytes weakly stimulate epithelial cells to
Definition
secrete ions and water
Term
Affinity
Definition
receptors binding to transmitters due to degree of attraction
Term
Efficac
Definition
ability to activate the intracellular machinery that mediates the physiological response
Term
Agonists
Definition
having both affinity and efficacy
Term
Competitive antagonist
Definition
react with receptors but lack efficacy
Term
Extracellular messengers
Definition
remain on exterior of cell
Term
Secondary messengers
Definition
activate intracellular machinery inside the cell
Term
Hormones and mediators are recognized by receptors that trigger release of
Definition
2nd messengers
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