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Physiology Final BSC2086
TCC- Dr. Momeny
133
Physiology
Undergraduate 2
12/09/2012

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Term
Anabolism
Definition
uses raw material to synthesize essential compounds
Term
Catabolism
Definition
decomposes substances to provide energy cells need to function
Term
Catabolism requires 2 essential ingredients?
Definition
Oxygen
Organic molecules broken down by intracellular enzymes
(ex. carbs, fats, proteins)
Term
Digestive tracts aka
Definition
alimentary canal
Term
6 Functions of the Digestive Tracts
Definition
Ingestion
Mechanical Processing
Digestion
Secretion
Absorption
Excretion
Term
Ingestion
Definition
occurs when materials enter digestive tract via the mouth
Term
Mechanical Processing
Definition
crushing and shearing
Term
Digestion
Definition
chemical breakdown of food into smaller organic fragments for absorption by digestive epithelium
Term
Secretion
Definition
release of water, acids, enzymes, buffers and salts
by epithelium of digestive tracts
by glandular organs
Term
Absorption
Definition
movements of organic substrates, electrolytes, vitamins, and water across digestive epithelium into interstitial fluid of digestive tract
Term
Excretion
Definition
removal of waste products from body fluids
Term
__________ removes feces
Definition
defecation
Term
Peritoneal Fluid
Definition
produced by serous membrane
provides essential lubrication
separates parietal and visceral surfaces
allows sliding without friction
~7 liters produced daily
Term
Ascites
Definition
excess peritoneal fluid causing abdominal swelling
Term
Four Layers of Digestive Tract
Definition
1. Mucosa
2. Submucosa
3. Muscularis externa
4. Serosa
Term
Mucosa
Definition
inner lining of digestive tract
lined by stratified squamous epithelium

includes: enteroendocrine cells
lamina propria& muscularis mucosae
Term
Lamina Propria
Definition
loose connective tissue (aerolar tissue)
containing blood vessels
sensory nerve endings
lymphatic vessels
smooth muscle cells
scattered areas of lymphoid tissues
Term
Muscularis Mucosae
Definition
narrow band of smooth muscle and elastic fibers in lamina propria
inner layer encircles lumen
Term
Submucosa
Definition
layer of dense, irregular connective tissue
large blood vessels and lymphatic vessels
may contain exocrine glands***
Term
Submucosal Plexus
Definition
plexus of Meissner*
contains:
sensory neurons
parasympathetic ganglionic neurons
sympathetic postganglionic fibers
Term
Serosa
Definition
serous membrane convering muscularis externa
Term
What moves digestive materials?
Definition
visceral smooth muscle tissue
has rhythmic cycles of activity
Term
Peristalsis
Definition
contraction through entire muscular sheet
Term
Segmentation
Definition
does not have a set pattern
does not push material in any one direction
Term
Secretion of the stomach
Definition
Carbonic anhydrase converts H20 + Co2 to H2CO3

H2CO3 dissociates to H+ and HCO3-

H+ is pumped out to the stomach lumen by H+/K+ pump

HCO3 is exchanged by Cl- which increases Cl concentration inside the parietal cell

Cl- diffuses to the stomach due to high concentration in the lumen due high concentration in parietal cells
Term
Tongue
Definition
secretion of mucins and enzyme lingual lipase
Term
lingual lipase
Definition
to break down lipids
Term
Parotid Salivary Glands
Definition
produce serous secretion
enzyme salivary amylase (breaks down starches)
Term
Sublingual Salivary Glands
Definition
produce mucous secretion
Term
Submandibular Salivary Glands
Definition
secrete buffer, glycoproteins(mucins) and salivary amylase
Term
Saliva
Definition
Produce 1.0-1.5 liters of saliva each day

70% by submandibular glands

99.4% water

Buffers NCO3

Enzymes
Term
Functions of Saliva
Definition
moistening and lubricating materials in the mouth

initiating digestion of complex carbs by the enzyme salivary amylase
Term
What accelerates secretion of salivary glands?
Definition
parasympathetic
Term
Wall of esophagus has?
Definition
3 layers

mucosa
submucosa
muscularis
Term
Major Functions of the Stomach
Definition
storage of ingested food
mechanical breakdown of ingested food
disruption of chemical bonds in food material by acid and enzymes
Production of intrinsic factor, a glycoprotein required for absorption of vitamin B12 in the small intestine
Term
Regions of the stomach
Definition
cardia
fundus
body
pylorus
Term
Preliminary Digestion in stomach by:
Definition
pepsin
Term
Small intestine
Definition
plays key role in digestion and absorption of nutrients
90% of nutrient absorption occurs in small intestine
Term
3 Sections of Small Intestine
Definition
Duodenum

Jejunum

Ileum
Term
What type of epithelium lines the stomach?
Definition
simple columnar
Term
Gastric pits
Definition
shallow depressions that open onto the gastric surface
Term
Parietal Cells
Definition
secrete intrinsic factors (required for B12 absorption) and hydrochloric acid
Term
Chief Cells
Definition
most abundant near base of gastric gland

secrete pepsinogen (inactive)

HCL converts to pepsinogen to pepsin (break down proteins,conversion of pepsinogen to pepsin)
Term
Pyloric Glands
Definition
produce mucous secretion
G cells
D cells
Term
G cells produce:
Definition
gastrin (hormone)
Term
D cells release
Definition
somatostatin (hormone inhibits release of gastrin)
Term
Where are motor neurons located?
Definition
myenteric plexus
Term
Motor neurons
Definition
control smooth muscle contraction which causes movement of materials along digestive tract and glandular secretion
Term
Short Reflexes
Definition
local reflexes
small segments of digestive tract
operate completely outside the CNS
Term
Long Reflexes
Definition
Higher level of control of digestive and glandular activities
control large peristaltic waves
involve interneurons and motor neurons in CNS
Term
Hormonal Mechanisms
Definition
18 peptide hormones that affect:
most aspects of digestive function
activities of other systems
Term
Functions of the Oral Cavity
Definition
Sensory analysis of material before swallowing
mechanical processing through actions of the teeth, tongue
Lubrication: mixing with mucous and salivary gland secretion
Limited digestion** of carbs and lipids**
Term
Oral Mucosa
Definition
nonkeratinized stratified squamous epithelium
Term
Duodenal Glands
Definition
produce a lot of mucus
when chyme arrives from stomach
Term
Intestinal Secretions
Definition
watery intestinal juice
1.8 liters er day that enters intestinal lumen
Term
Once chyme reaches duodenum?
Definition
weak peristaltic contractions move it slowly toward jejunum
via parasympathetic stimulation
Term
If __________ hormones absent during fetal development?
Definition
nervous system fails to develop
mental retardation occurs

if T4 concentration decline prior to puberty, normal skeletal development will not continue
Term
Insulin
Definition
allows passage of glucose and amino acids across plasma membranes
Term
Parathyroid Hormone
Definition
promote absorption of calcium salts for deposition in bone

inadequate levels cause weak and flexible bones
Term
Growth Hormone in adults
Definition
maintains normal blood glucose concentrations

mobilizes lipid reserves
Term
Leptin
Definition
feedback control for appetite

controls normal levels of GnRH
Term
_________ _______ secrete inhibin
Definition
nurse cells
Term
testes produce
Definition
androgens in interstitial cells
testosterone
Term
Thymus
Definition
produces thymosins

help develop and maintain normal immune defenses.
Term
Adrenal Cortex 3 regions
Definition
Zone glomerulosa
Zona fasiculata
Zona reticularis
Term
Zona glomerulosa
Definition
outermost layer

mineralcorticoids (aldosterone)
Term
Zona fasiculata
Definition
middle layer

glucoccorticoids
Term
Zona reticularis
Definition
sex hormones
Term
G
F
R
Definition
mineralocortocoids
glucoccorticoids
sex hormones
Term
Hormone released by adrenal medulla
Definition
epinephrine & norepinephrine
Term
Adrenal medulla is part of:
Definition
sympathetic nervous system
Term
Endocrine cells of pancreas
Definition
alpha
beta
delta cells
Term
3 effects of PTH
Definition
stimulates osteoclasts and inhibits osteoblasts

enhances reabsorption of Ca2+ at kidneys, reducing urinary losses

Stimulates formation and secretion of calcitrol by the kidneys
Term
Normal Blood Glucose Level
Definition
70 - 110
Term
Thyroid Hormones can bind to receptors
Definition
cytoplasm
surfaces of mitochondria
nucleus
Term
Calcitonin
Definition
helps regulate concentrations of Ca2+ in body fluids

inhibits osteoclasts, which slow the rate of Ca2+ release from bone

Stimulates Ca2+ excretion by kidneys
Term
Folicullar Cells produce:
Definition
thyroid hormones
T3 and T4
Term
Oxytocin
Definition
labor contractions
Term
ADH
Definition
reabsorption of water

elevated blood pressure and volume
Term
Pituitary to Adrenal
Definition
ACTH
Term
Pituitary to thyroid
Definition
TSH
Term
Pituitary to liver
Definition
GH
Term
Pituitary to Breast
Definition
prolactin
Term
Pituitary to Gonads
Definition
FSH & LH
Term
Pituitary to Melanocyte
Definition
MSH
Term
Posterior Pituitary to Uterus
Definition
oxytocin
Term
Posterior Pituitary to Ductus deferns and prostate
Definition
oxytocin
Term
Posterior Pituitary to Kidney
Definition
ADH
Term
Adrenal Gland produces
Definition
epinephrine and norepinephrine

glucoccortiocoids (cortisol)
Term
Thyroid produces
Definition
T3 and T4
Term
Testes produces
Definition
testosterone and inhibin
Term
Ovaries produce
Definition
estrogen, inhibin and progesterone
Term
Liver produces
Definition
somatomedins
Term
Melatonin
Definition
circadian rhythm
Term
PTH causes and __________ in Ca2+ blood
Definition
increase
Term
__________ __ is needed for Ca2+ regulation
Definition
vitamin D
Term
Alpha cells
Definition
produce glucagon
Term
Beta cells
Definition
produce insulin
Term
Delta cells
Definition
produce peptide hormones identical to GH-IH
Term
F cells
Definition
secrete pancreatic polypeptide (PP)
Term
How is insulin released?
Definition
by beta cells
Term
Insulin
Definition
accelerated glucose uptake
accelerates glucose utilization and enhances ATP
Stimulates glycogen formation
Stimulates amino acid absorption and protein synthesis
Stimulates triglyceride formation in adipose tissue
Term
After glucose levels fall, _______ _______ in the pancreas secrete _________
Definition
alpha cells

glucagon
Term
Insulin _________ blood ___________
Definition
decreases

glucose
Term
What hormones increase blood glucose?
Definition
glucagon
glucoccorticoids like cortisol
GH
catechloamines (epi and norepinephrine)
Term
Type 1 Diabetes
Definition
insulin dependent

no production of insulin by pancreatic beta cells
Term
Type 2 Diabetes
Definition
most common form
insulin resistance
usually associated with obesity
Term
Kidneys produce
Definition
calcitriol
erythropoietin
enzyme renin
Term
GAS
Definition
stress response
Term
Three phases of stress response
Definition
Alarm
Resistance
Exhaustion
Term
Alarm phase
Definition
sympathetic activation
adrenal medulla activated
release of epi or noepinephrine
Term
Resistance Phase
Definition
glucoccorticoids (from adrenal medulla)
epinephrine
GH
thyroid hormones
Term
Exhaustion Phase
Definition
failure of electrolyte balance
inability to produce glucoccorticoids
Term
Parathyroid and Calcitonin regulate calcium
Definition
promote absorption of calcium salts for deposition in bone

low levels can cause weak and flexible bones
Term
Releasing hormones from hypothalamus
Definition
TRH -> TSH -> increase thyroid hormones
CRH -> ACTH -> increase glucoccorticoids
GnRH ->LH & FSH -> ^ inhibin, progestins, androgens, estrogens
Term
Hypothalamus releases
Definition
regulatory hormones which blood vessels carry to the anterior pituitary gland

this vessel forms a portal system
Term
LH in males
Definition
targets interstitial cells the secrete testosterone & other androgens
Term
FSH males
Definition
with testosterone present this FSH will promote spermatogenesis
Term
What cells produce testosterone?
Definition
interstitial cells
Term
Effect of inhibin on gonadotrophins?
Definition
inhibits FSH secretion
Term
What ovary cell produces progesterone?
Definition
corpus luteum
Term
What ovary cell produces estrogen?
Definition
follicles
Term
Functions of the Large Intestine
Definition
reabsorption of water
compaction of intestinal contents into feces
absorption of imp vitamins produced by bacteria
storage of fecal material prior to defecation
Term
Pancreatic acini
Definition
exocrine secretion of pancreas
Term
Pancreatic alpha-amylase
Definition
breaks down starches
Term
Pancreatic lipase
Definition
breaks down complex lipids
Term
Nucleases
Definition
break down nucleic acids
Term
Proteolytic Enzymes
Definition
70% of all pancreatic enzyme production**
Term
proteases
Definition
break large protein complexes
Term
peptidases
Definition
break small peptides into amino acids
Term
After ovulation ___________ levels decrease
Definition
estrogen levels

and progesterone increase
Term
GnRH
males vs female
Definition
male stays the same

female different throughout cycle
Term
GnRH
Definition
from hypothalamus
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