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Pharmacology 6 Renal/Urinary Disorders
Drugs used for Renal and Urinary System Disorders
10
Veterinary Medicine
Undergraduate 2
10/19/2014

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Cards

Term
Functions of the Kidney
Definition
Filter waste products from the blood

acid/base balance

regulation of electrolyte concentrations

blood volume control

regulation of blood pressure
Term
Results of reduced kidney function
Definition
Improper erythropoiesis

Uremia may cause some tissues to be more sensitive to certain drugs

Impaired excretion or biotransformation of drugs
Term
Renal failure: likely causes
Definition
Infectious disease (i.e. leptospirosis), Diabetes Mellitus, toxins, congenital disorders, immunologic problems, amyloidosis, diets high in protein, phosphorous, sodium
Term
Renal failure: types
Definition
Prerenal

renal

postrenal
Term
Renal failure: grades
Definition
acute

chronic

end-stage
Term
Diuretic drugs
Definition
Remove excess extracellular fluid by increasing urine flow & sodium excretion, also reduces hypertension
Term
Loop Diuretics
Definition
inhibit tubular reabsorption of sodium, promoting excretion of chloride, potassium, water

Examples: Furosemide

Adverse: hypokalemia
Term
Osmotic Diuretics
Definition
Promotes diuresis by exerting high osmotic pressure in the tubules & limiting tubular reabsorption

Use: Oliguric ARF, reduce intracranial pressure

Examples: mannitol, glucose
Term
Thiazide diuretics
Definition
Reduce edema by inhibiting reabsorption of sodium, chloride, water

Ex: Chlorothiazide, hydrochlorothiazide

Adverse: hypokalemia
Term
Potassium sparing diuretics
Definition
Weaker diuretic and antihypertensive effects but conserves potassium

Function: Aldosterone antagonists increases excretion of sodium and water

Ex: Spironolactone
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