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Definition
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Term
| name two antivirals that tx herpes infections |
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Definition
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Definition
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Definition
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| targets of antiviral drugs = |
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Definition
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Term
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Definition
inhibit penetration and uncoating of influenza A virus in man.
Does this by blocking fusion of viral N2 protein that makes ion channel and causes acidification of virus endosome |
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| oral bioavaliablilty of amatadine = |
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Definition
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| plasma half life of amantadine = |
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Definition
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| what anitiviral drugs target attachment? |
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Definition
| amantadine (most effective prevention step in antiviral therapy) |
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| what antiviral drugs target virus replication? |
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Definition
idoxuridine
acyclovir
azidothymidine (AZT) |
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Term
| idoxuridine used in tx of... |
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Definition
| ...cats and horses with herpetic keratitis (corneal infections of herpes virus) |
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Term
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Definition
| inhibit replication of DNA viruses - mainly herpes |
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| why is idoxuridine only admin topically and not systemically? |
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Definition
| as effects euk DNA replication as well - too toxic admin systemically (=BM supression) |
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Definition
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| how does acyclovir-prodrug become activtaed |
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Definition
| phosphorylated once by viral kinases and then twice by host cell kinases = active drug |
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| 2 points of selective toxicity of acyclovir = |
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Definition
viral kinase needed to mak eprodrug active
inhibit viral DNA pol 10-30x more than euk DNA pol |
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| clinical use of acyclovir = |
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Definition
| tx of feline and equine herpes 1 virus eye infections - othalmic ointment |
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| at sp is acyclovir most effective in? |
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Definition
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Term
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Definition
reverse transcriptase inhibitor
(reverse transcriptase is req for retrovirus replication) |
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| 2 points of viral selectivity with AZT |
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Definition
1. need viral kinases to phosphorylate prodrug (like acyclovir - same mech-need host cell kinases too)
2. HIV viral reverse transcriptase 100x more sensitive to AZT than euk DNA pol |
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Term
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Definition
...FIV
incr survival time and alleviate symptoms temporarily = improve quality of life
no effect on viraemia :(
(less effective against FeLV) |
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Term
| toxic side effects of AZT = |
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Definition
severe anaemia as targets rapidly dividing cells = severe BM supression = anaemia
and liver toxicity problems |
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Term
| how many days of AZT tx until start seeing clinical improvement? |
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Definition
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