Shared Flashcard Set

Details

Penicillins
VM 607 Final
14
Veterinary Medicine
Professional
02/18/2012

Additional Veterinary Medicine Flashcards

 


 

Cards

Term
Basic Penicillins Group
Definition
penicillin G and V
Term
Aminopenicillins
Definition
amoxicillin, ampicillin
Term
Beta lactamase-resistant penicillins
Definition
methicillin, oxacillin
Term
Extended spectrum penicillins
Definition
ticarcillin, piperacillin
Term
Activity
Definition
bactericidal
time-dependent
post-antibiotic effect
eagle effect - when you reach too high of a local concentration can lose efficacy
Term
Pencillin Action
Definition
extracellular
poor penetration inside cells
Term
Regular penicillin Action
Definition
Gram + including anaerobes
Pasteurella
Term
Aminopenicillins Action
Definition
Gram + including anaerobes
Pasteurella and some extension to other Gram -
Term
Antistaphylococcal Penicillins Action
Definition
Gram + including betalactamase + and anaerobes
less efficient against Gram + anaerobes and Gram -
Term
Anti-pseudomonal penicillins
Definition
Gram + and Gram - including anaerobes
less efficient against Gram +
Term
Penicillin Combinations
Definition
synergy with aminoglycosides
wall disruption increases aminoglycoside penetration
cannot be mixed in a syringe because will precipitate
synergy with beta lactamase inhibitors
Term
Pharmacokinetics
Definition
degraded by GI amidases, bacterial beta lactamases, acidity, alkalinity
poor oral bioavailability
poor efficacy in presence of pus and tissue debris
Term
Adverse Effects
Definition
Type A
effects on gut flora - GI upset
cardiac arrest with rapid IV injection of K-salts or procaine
CNS toxicity with procaine formulas with horses

Type B
frequent compared to other drugs
risk for cross-reactivity between penecillins and cephalosporins
Term
Clinical Usage
Definition
Pencillins A - don't use in guinea pigs or rabbits because of GI upset

Anti-pseudomonal penicllinins
never use empirically
never use as first line
limited vet use only if confirmed pseudomonas infection
Supporting users have an ad free experience!