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Pemphigus and lupus diseases
pemphigus/lupus
16
Veterinary Medicine
Professional
07/08/2020

Additional Veterinary Medicine Flashcards

 


 

Cards

Term
This molecule is the major immunologic target in pemphigus foliaceus in dogs
Definition
Desmocollin I

Cloning and Establishment of Canine desmocollin-1 as a Major Autoantigen in Canine Pemphigus Foliaceus
Term
This is the breed most commonly affected with exfoliative cutaneous lupus erythematosus
Definition
German Shorthaired Pointers

Some recent success with tx with mycophenolate
Term
What is the major antigen in canine pemphigus vulgaris?
Definition
Desmoglein 3, and maybe also desmoglein 1 sometimes
Term
Name the dominant immunoglobulin isotype found in the positive lupus band test in German shepherd dogs with mucocutaneous lupus erythematosus?
Definition
  • direct IF reveals a positive IgG lupus band
Term
Name 2 auto-antibody targets that have been identified in mucous membrane pemphigoid in dogs.
Definition
  • NC16 A domain of Collagen 17 and Laminin 332
Term
What is the desmosomal antigen targeted in pemphigus foliaceus?
Definition
  • Desmocollin-1 primarily in dogs
  • Dsg 1 and DsC1 are both involved
  • The binding of the autoantibody to the cadherins leads to disruption of intercellular adhesion resulting in acantholysis
Term
What is the desmosomal antigen targeted in pemphigus vulgaris?
Definition
  • pemphigus vulgaris (Dsg 3)
  • Binding of autoantibody to the cadherins leads to disruption of intercellular adhesion resulting in acantholysis
Term
What lesions are due to T lymphocyte-mediated damage of keratinocytes?
Definition
  • Antikeratinocyte
    • Vesicular cutaneous lupus erythematosus
    • Exfoliative cutaneous lupus erythematosus
    • Discoid cutaneous lupus erythematosus (facial and generalized)
    • Mucocutaneous cutaneous lupus erythematosus
Term
What dog breeds are predisposed to pemphigus foliaceus?
Definition
  • Akita
  • Chow Chow
  • Doberman
  • Schipperke
  • Labrador 
  • Australian Shep
  • English Cocker
  • Chinese shar pei
  • Dachshund
  • Collies
Term
What dog breeds are most predisposed to Pemphigus erythematosus?
Definition
  • Collie
  • GSD
Term
What dog breeds are most predisposed to Pemphigus erythematosus?
Definition
  • Collie
  • GSD
Term
What dog breeds are predisposed to Facial vs. Generalized discoid lupus erythematosus?
Definition
  • Facial: GSD, Collies, Shetland Sheepdog, Siberian husky
  • Generalized: Chinese crested and Labrador retriever
Term
What dog breeds are predisposed to Mucocutaneous Lupus erythematosus?
Definition
  • GSD
  • Belgian shepherd
Term
What dog breed is predisposed to vesicular lupus?
Definition
  • Collie
Term
What dog breeds are predisposed to Exfoliative lupus erythematosus?
Definition
  • German shorthair pointer
  • Vizsla
Term
Name two autoantibody targets that have been identified in mucous membrane pemphigoid in dogs.
Definition
  • NC16A domain of Collagen 17
  • Laminin 332
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